NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=1735725 [NCBI, ExPASy, EBI, Israel, Japan]
Wallbrandt P., Tegman V., Jonsson B.-H., Wieslander A.;
"Identification and analysis of the genes coding for the putative pyruvate dehydrogenase enzyme complex in Acholeplasma laidlawii.";
J. Bacteriol. 174:1388-1396(1992).

Comments

FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate.
SUBUNIT: Heterodimer of an alpha and a beta chain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M81753; AAA21908.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

B42653; B42653.

3D structure databases

HSSP

Q8ZUR7; 1IK6. [HSSP ENTRY / PDB]

ModBase

P35488.

Family and domain databases

InterPro

IPR005476; Transketo_C.
IPR005475; Transketo_Cen_R.
IPR015941; Transketolase_C-like.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.920; Transketo_C_like; 1.

Pfam

PF02779; Transket_pyr; 1.
PF02780; Transketolase_C; 1.
Pfam graphical view of domain structure.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Glycolysis; Oxidoreductase; Pyruvate; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 327`	`327`	`Pyruvate dehydrogenase E1 component subunit beta.`	`PRO_0000162220`
`BINDING`	`60 60`		`Thiamine pyrophosphate (By similarity).`

Sequence information

Length: 327 AA [This is the length of the unprocessed precursor]

Molecular weight: 35682 Da [This is the MW of the unprocessed precursor]

CRC64: F71D6DE807CDBE1C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAIITLLEAI NQAIDQAMEK DESIVVFGED AGFEGGVFRV TAGLQKKYGE TRVFDTPIAE 

        70         80         90        100        110        120 
SAIVGSAVGM AINGLKPIAE IQFDGFIFPG YTDLVTHAAR MRNRSRGQFT VPMVLRLPHG 

       130        140        150        160        170        180 
GGIRALEHHS EALEVLFGSI PGLKVVTPST PYDAKGLLLA AINDPDPVVF LEPKRIYRAG 

       190        200        210        220        230        240 
KQEVPAEMYE IPIGKAKVVK QGTDMTVVAW GSIVREVEKA VKLVEAEGIS VEIIDLRTIS 

       250        260        270        280        290        300 
PIDEETILNS VKKTGKFMVV TEAVKSYGPA AELITMVNEK AFFHLEAAPV RFTGFDITVP 

       310        320 
LARGEHYHFP QPEKIAAYIR KLAKARP

P35488 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools