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UniProtKB/Swiss-Prot entry P35430

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AHD2_TETPY
Primary accession number P35430
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 1, 1994 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 24)
Name and origin of the protein
Protein name 20-alpha-hydroxysteroid dehydrogenase [Fragment]
Synonyms 20-alpha-HSD
EC 1.1.1.149
Gene name None
From
Tetrahymena pyriformis [TaxID: 5908] 
Taxonomy Eukaryota; Alveolata; Ciliophora; Intramacronucleata; Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae; Tetrahymena.
Protein existence 1: Evidence at protein level;
References
[1]
 PROTEIN SEQUENCE, AND CHARACTERIZATION.
STRAIN=W;
PubMed=8280099 [NCBI, ExPASy, EBI, Israel, Japan]
Inazu A., Sato K., Nakayama Y., Hara A., Nozawa Y.;
"Purification and characterization of a novel dimeric 20 alpha-hydroxysteroid dehydrogenase from Tetrahymena pyriformis.";
Biochem. J. 297:195-200(1994).
Comments
  • FUNCTION: Specific for the oxidation of the 20-alpha hydroxy group of 17-alpha-hydroxyprogesterone and 17-alpha-hydroxypregnenolone.
  • CATALYTIC ACTIVITY: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17-alpha-hydroxyprogesterone + NAD(P)H.
  • SUBUNIT: Homodimer.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
PIR S40502; S40502.
3D structure databases
ModBase P35430.
Ontologies
GO
GO:0047006; Molecular function: 20-alpha-hydroxysteroid dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
BLOCKS P35430.
ProtoNet P35430.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   >18  >18     20-alpha-hydroxysteroid dehydrogenase. PRO_0000064503
NON_TER   18    18         
Sequence information
Length: 18 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 1861 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: 16DF6B287E3B0A0D [This is a checksum on the sequence] 
        10 
LAKTVPLNDG TNFPIFGG
P35430 in FASTA format

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