[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-44. STRAIN=SI-4; PubMed=8254318 [NCBI, ExPASy, EBI, Israel, Japan] Schneider K.-H., Giffhorn F., Kaplan S.; "Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides."; J. Gen. Microbiol. 139:2475-2484(1993).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=SI-4; Schneider K.-H., Giffhorn F.; Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: D-mannitol + NAD⁺ = D-fructose + NADH.
SUBUNIT: Monomer.
SIMILARITY: Belongs to the mannitol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF018073; AAC45771.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

O08355; 1LJ8. [HSSP ENTRY / PDB]

ModBase

P33216.

Family and domain databases

InterPro

IPR013328; DHase_multihelical.
IPR013118; Mannitol_DHase_C.
IPR000669; Mannitol_DHase_core.
IPR013131; Mannitol_DHase_N.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.

Pfam

PF01232; Mannitol_dh; 1.
PF08125; Mannitol_dh_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00084; MTLDHDRGNASE.

PROSITE

PS00974; MANNITOL_DHGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 477`	`476`	`Mannitol 2-dehydrogenase.`	`PRO_0000170734`
`NP_BIND`	`19 30`	`12`	`NAD (By similarity).`

Sequence information

Length: 477 AA [This is the length of the unprocessed precursor]

Molecular weight: 51538 Da [This is the MW of the unprocessed precursor]

CRC64: F823623B7BA920E8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTRSVTRPSY DRKALTPGIV HIGVGNFHRA HQAVYLDDLF ALGEGHDWAI LGAGVRPTDA 

        70         80         90        100        110        120 
RMREALAAQD NLSTVIELDP AGHRARQVGA MVGFLPVEAD NAALIEAMSD PRIRIVSLTV 

       130        140        150        160        170        180 
TEGGYYVDAS GAFDPTHPDI VADAAHPARP ATAFGAILAA LRARRDAGVT PFTVMSCDNL 

       190        200        210        220        230        240 
PGNGHVTRNA VVGLAELYDA ELAGWVKAQV AFPNGMVDRI TPATGPHERE LAQGFGLADP 

       250        260        270        280        290        300 
VPVTCEPFRQ WVIEDHFPAG RPALEKVGVT FTPHVHAYEA MKIRILNGGH AVIAYPSALM 

       310        320        330        340        350        360 
DIQLVHAAMA HPLIAAFLHK VEVEEILPHV PPVPDTSIPD YLTLIESRFS NPEIADTTRR 

       370        380        390        400        410        420 
LCLDGSNRQP KFIVPSLRDN LAAGTVPKGL VLLSALWCRY CFGTTDSGVV VEPNDPNWTA 

       430        440        450        460        470 
LQDRARRAKE TPAEWLAMTE VYGDLAQNDL LAAEFAAALE AVWRDGAEAV LRRFLAA

P33216 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools