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UniProtKB/Swiss-Prot entry P32872

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALDHY_YEAST
Primary accession number P32872
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on October 1, 1993 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 58)
Name and origin of the protein
Protein name Aldehyde dehydrogenase 2, mitochondrial [Precursor]
Synonym EC 1.2.1.3
Gene name
Name: ALD2
Synonyms: ALDH2
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Thielen J.;
Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z17314; CAA78962.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S31308; S31308.
3D structure databases
HSSP P05091; 1O04. [HSSP ENTRY / PDB]
ModBase P32872.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS P32872.
Other
ProtoNet P32872.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    21  21     Mitochondrion. 
CHAIN   22   511  490     Aldehyde dehydrogenase 2, mitochondrial. PRO_0000007164
NP_BIND   274   279  6     NAD (By similarity). 
ACT_SITE   297   297        Proton acceptor (By similarity). 
ACT_SITE   331   331        Nucleophile (By similarity). 
SITE   198   198  1     Transition state stabilizer (By similarity). 
Sequence information
Length: 511 AA [This is the length of the unprocessed precursor] Molecular weight: 56466 Da [This is the MW of the unprocessed precursor] CRC64: 70EDAE951B84EE4A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKSKTKTDK RNQSSLSRIK LSALHYCMSD AEPSIAYLQD NSAFINNEWH NLVLEKIFPV 

        70         80         90        100        110        120 
YNPSTEEDIT QVSEKSQHDS TEEDITQVSE KSQHDDDKAV VDISERGRLL NILADLIERD 

       130        140        150        160        170        180 
RDILAAIEHL DNGKPFDEAY LLDLASVLKE LRYTAGWADK LHGTLRFAIT IPTFQDLRFL 

       190        200        210        220        230        240 
RYTRHEPVGV CGEIIPWNIP LLMYIWKIGP ALAAGNTVVL KPEELTPLTA LTVATLIKEA 

       250        260        270        280        290        300 
GFPPGVVNVV SGYGPTAGAA CLSHKDNDKL AFTGSTLVGK VVMKAAAKSN LKKVTLELGG 

       310        320        330        340        350        360 
KSPMIVFIDA DLDWAVENAH FGVFFNQGQC CIAQSRITVH ESIYDEIVER DLEKAKKQVL 

       370        380        390        400        410        420 
GNPFESDTRY GPQILKIEFD SIPRLINSAK AEGAKVLCGG GRDDSCVGYY IQPTVFADVT 

       430        440        450        460        470        480 
DEMRIAKEEI FGPVITISRF KSVDEAIKRV DNTKYGLAAY VFTKDKAIRI SAALKAGTVW 

       490        500        510 
VNCVHVASYQ IPFGGNKNSG MGRELGEYGL E
P32872 in FASTA format

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