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UniProtKB/Swiss-Prot entry P31644


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GBRA5_HUMAN
Primary accession number P31644
Secondary accession numbers Q14DC2 Q53XL6 Q9NYT3 Q9NYT4 Q9NYT5
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on July 1, 1993 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 90)
Name and origin of the protein
Protein name Gamma-aminobutyric acid receptor subunit alpha-5 [Precursor]
Synonym GABA(A) receptor subunit alpha-5
Gene name
Name: GABRA5
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/hmg/2.2.183; PubMed=8388764 [NCBI, ExPASy, EBI, Israel, Japan]
Knoll J.H., Sinnett D., Wagstaff J., Glatt K.A., Wilcox A.S., Whiting P.J., Wingrove P., Sikela J.M., Lalande M.;
"FISH ordering of reference markers and of the gene for the alpha 5 subunit of the gamma-aminobutyric acid receptor (GABRA5) within the Angelman and Prader-Willi syndrome chromosomal regions.";
Hum. Mol. Genet. 2:183-189(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1321750 [NCBI, ExPASy, EBI, Israel, Japan]
Wingrove P., Hadingham K., Wafford K., Kemp J.A., Ragan C.I., Whiting P.;
"Cloning and expression of a cDNA encoding the human GABA-A receptor alpha 5 subunit.";
Biochem. Soc. Trans. 20:18S-18S(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-166; 195-241 AND 294-363.
Kim S.-J., Gonen D., Yang Z.-Y., Reliford A., Dy A., Leventhal B.L., Cook E.H. Jr.;
"Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 5 subunit gene (GABRA5).";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29.
TISSUE=Fetal brain;
DOI=10.1006/geno.1997.4770; PubMed=9205108 [NCBI, ExPASy, EBI, Israel, Japan]
Kim Y., Glatt H., Xie W., Sinnett D., Lalande M.;
"Human gamma-aminobutyric acid-type A receptor alpha5 subunit gene (GABRA5): characterization and structural organization of the 5' flanking region.";
Genomics 42:378-387(1997).
[7]
UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-355, AND MASS SPECTROMETRY.
DOI=10.1002/pmic.200600410; PubMed=17370265 [NCBI, ExPASy, EBI, Israel, Japan]
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.";
Proteomics 7:868-874(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L08485; AAA58490.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT009830; AAP88832.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC111979; AAI11980.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC113422; AAI13423.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228447; AAF62508.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228448; AAF62509.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228449; AAF62510.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF061785; AAC31809.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A48933; A48933.
RefSeq NP_000801.1; -.
UniGene Hs.612087
3D structure databases
ModBase P31644.
Organism-specific databases
H-InvDB HIX0026792; -.
HGNC HGNC:4079; GABRA5.
GenAtlas GABRA5.
MIM 137142; gene. [NCBI / EBI]
PharmGKB PA28493; -.
GeneCards P31644.
Gene expression databases
ArrayExpress P31644; -.
CleanEx HS_GABRA5; -.
GermOnline ENSG00000186297; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004872; Molecular function: receptor activity (traceable author statement from ProtInc).
GO:0005215; Molecular function: transporter activity (traceable author statement from ProtInc).
GO:0007165; Biological process: signal transduction (traceable author statement from ProtInc).
GO:0006810; Biological process: transport (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR006028; GABAA_rcpt.
IPR001390; GABAAa_rcpt.
IPR005435; GABBAa5_rcpt.
IPR006029; Neu_channel_TM.
IPR006202; Neur_chan_lig_bd.
IPR006201; Neur_channel.
Graphical view of domain structure.
Gene3D G3DSA:2.70.170.10; Neur_chan_lig_bd; 1.
PANTHER PTHR18945; Neur_channel; 1.
Pfam PF02931; Neur_chan_LBD; 1.
PF02932; Neur_chan_memb; 1.
Pfam graphical view of domain structure.
PRINTS PR01079; GABAARALPHA.
PR01618; GABAARALPHA5.
PR00253; GABAARECEPTR.
PR00252; NRIONCHANNEL.
TIGRFAMs TIGR00860; LIC; 1.
PROSITE PS00236; NEUROTR_ION_CHANNEL; 1.
BLOCKS P31644.
ProtoNet P31644.
Genome annotation databases
Ensembl ENSG00000186297; Homo sapiens. [Contig view]
GeneID 2558; -.
KEGG hsa:2558; -.
Phylogenomic databases
HOGENOM P31644; -.
HOVERGEN P31644; -.
Other
DrugBank DB00404; Alprazolam.
DB00189; Ethchlorvynol.
DB01544; Flunitrazepam.
DB00690; Flurazepam.
DB00186; Lorazepam.
DB00371; Meprobamate.
DB00683; Midazolam.
NextBio 10103; -.
SOURCE GABRA5; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell junction; Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion transport; Ionic channel; Membrane; Postsynaptic cell membrane; Signal; Synapse; Transmembrane; Transport; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    31  31     Potential. 
CHAIN   32   462  431     Gamma-aminobutyric acid receptor subunit alpha-5. PRO_0000000444
TOPO_DOM   32   259  228     Extracellular (Potential). 
TRANSMEM   260   281  22     Potential. 
TRANSMEM   286   307  22     Potential. 
TRANSMEM   319   341  23     Potential. 
TOPO_DOM   342   427  86     Cytoplasmic (Potential). 
TRANSMEM   428   449  22     Potential. 
CARBOHYD   45    45        N-linked (GlcNAc...) (Potential). 
CARBOHYD   145   145        N-linked (GlcNAc...) (Potential). 
CARBOHYD   207   207        N-linked (GlcNAc...) (Potential). 
CARBOHYD   236   236        N-linked (GlcNAc...) (Potential). 
DISULFID   173   187        By similarity. 
CROSSLNK   355   355        Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). 
Sequence information
Length: 462 AA [This is the length of the unprocessed precursor] Molecular weight: 52146 Da [This is the MW of the unprocessed precursor] CRC64: 260A8B554113AFF9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDNGMFSGFI MIKNLLLFCI SMNLSSHFGF SQMPTSSVKD ETNDNITIFT RILDGLLDGY 

        70         80         90        100        110        120 
DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF RQSWKDERLR FKGPMQRLPL 

       130        140        150        160        170        180 
NNLLASKIWT PDTFFHNGKK SIAHNMTTPN KLLRLEDDGT LLYTMRLTIS AECPMQLEDF 

       190        200        210        220        230        240 
PMDAHACPLK FGSYAYPNSE VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS 

       250        260        270        280        290        300 
TGEYTIMTAH FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM 

       310        320        330        340        350        360 
TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA WDGKKALEAA 

       370        380        390        400        410        420 
KIKKKREVIL NKSTNAFTTG KMSHPPNIPK EQTPAGTSNT TSVSVKPSEE KTSESKKTYN 

       430        440        450        460 
SISKIDKMSR IVFPVLFGTF NLVYWATYLN REPVIKGAAS PK 

P31644 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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