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UniProtKB/Swiss-Prot entry P31039

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHSA_BOVIN
Primary accession number P31039
Secondary accession number Q9TUY8
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on August 16, 2004 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 79)
Name and origin of the protein
Protein name Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [Precursor]
Synonyms EC 1.3.5.1
Flavoprotein subunit of complex II
Fp
Gene name
Name: SDHA
Synonyms: SDH2, SDHFP1
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Heart;
PubMed=1375942 [NCBI, ExPASy, EBI, Israel, Japan]
Birch-MacHin M.A., Farnsworth L., Ackrell B.A.C., Cochran B., Jackson S., Bindoff L.A., Aitken A., Diamond A.G., Turnbull D.M.;
"The sequence of the flavoprotein subunit of bovine heart succinate dehydrogenase.";
J. Biol. Chem. 267:11553-11558(1992).
[2]
 SEQUENCE REVISION.
DOI=10.1016/0005-2728(94)90203-8; PubMed=8142412 [NCBI, ExPASy, EBI, Israel, Japan]
Morris A.A.M., Farnsworth L., Ackrell B.A.C., Turnbull D.M., Birch-MacHin M.A.;
"The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase.";
Biochim. Biophys. Acta 1185:125-128(1994).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 153-253.
STRAIN=Hereford X Nelore;
PubMed=10612251 [NCBI, ExPASy, EBI, Israel, Japan]
Sonstegard T.S., Kappes S.M.;
"Mapping of the SDHA locus to bovine chromosome 20.";
Anim. Genet. 30:473-473(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M60879; AAA30758.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF139922; AAD38150.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A42792; A42792.
RefSeq NP_776603.1; -.
UniGene Bt.24449
3D structure databases
HSSP P10444; 1NEK. [HSSP ENTRY / PDB]
SMR P31039; 55-665.
ModBase P31039.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0008177; Molecular function: succinate dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR003953; FAD_bind2_N.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR003952; FRD_SDH_FAD_BS.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR011281; Succ_DHase_flav_su_fwd.
IPR014006; Succ_Dhase_frdA_Gneg.
Graphical view of domain structure.
Pfam PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00411; PNDRDTASEI.
TIGRFAMs TIGR01816; sdhA_forward; 1.
TIGR01812; sdhA_frdA_Gneg; 1.
PROSITE PS00504; FRD_SDH_FAD_BINDING; 1.
Genome annotation databases
GeneID 281480; -.
KEGG bta:281480; -.
Phylogenomic databases
HOVERGEN P31039; -.
Other
ProtoNet P31039.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Phosphoprotein; Transit peptide; Transport; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    44  44     Mitochondrion. 
CHAIN   45   665  621     Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial. PRO_0000010334
NP_BIND   92   107  16     FAD (By similarity). 
ACT_SITE   341   341        Proton acceptor (By similarity). 
BINDING   297   297        Substrate (By similarity). 
BINDING   309   309        Substrate (By similarity). 
BINDING   408   408        Substrate (By similarity). 
BINDING   452   452        Substrate (By similarity). 
MOD_RES   100   100        Tele-8alpha-FAD histidine (By similarity). 
MOD_RES   180   180        N6-acetyllysine (By similarity). 
MOD_RES   253   253        Phosphothreonine (By similarity). 
MOD_RES   486   486        N6-acetyllysine (By similarity). 
MOD_RES   499   499        N6-acetyllysine (By similarity). 
MOD_RES   539   539        N6-acetyllysine (By similarity). 
CONFLICT   242   253        DGSIHRIRARNT -> ERVHPPHQGQEH (in Ref. 3). 
Sequence information
Length: 665 AA [This is the length of the unprocessed precursor] Molecular weight: 72944 Da [This is the MW of the unprocessed precursor] CRC64: FE51160F248D51BC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSGVAAVSRL WRARRLALTC TKWSAAWQTG TRSFHFTVDG NKRSSAKVSD AISAQYPVVD 

        70         80         90        100        110        120 
HEFDAVVVGA GGAGLRAAFG LSEAGFNTAC VTKLFPTRSH TVAAQGGINA ALGNMEEDNW 

       130        140        150        160        170        180 
RWHFYDTVKG SDWLGDQDAI HYMTEQAPAS VVELENYGMP FSRTEDGKIY QRAFGGQSLK 

       190        200        210        220        230        240 
FGKGGQAHRC CCVADRTGHS LLHTLYGRSL RYDTSYFVEY FALDLLMESG ECRGVIALCI 

       250        260        270        280        290        300 
EDGSIHRIRA RNTVIATGGY GRTYFSCTSA HTSTGDGTAM VTRAGLPCQD LEFVQFHPTG 

       310        320        330        340        350        360 
IYGAGCLITE GCRGEGGILI NSQGERFMER YAPVAKDLAS RDVVSRSMTL EIREGRGCGP 

       370        380        390        400        410        420 
EKDHVYLQLH HLPPAQLAMR LPGISETAMI FAGVDVTKEP IPVLPTVHYN MGGIPTNYKG 

       430        440        450        460        470        480 
QVLRHVNGQD QGVPGLYACG EAACASVHGA NRLGANSLLD LVVFGRACAL SIAESCRPGD 

       490        500        510        520        530        540 
KVPSIKPNAG EESVMNLDKL RFANGSIRTS ELRLNMQKSM QSHAAVFRVG SVLQEGCEKI 

       550        560        570        580        590        600 
SSLYGDLRHL KTFDRGMVWN TDLVETLELQ NLMLCALQTI YGAEARKESR GGPRREDFKE 

       610        620        630        640        650        660 
RVDEYDYSKP IQGQQKKPFE QHWRKHTLSY VDIKTGKVTL EYRPVIDRTL NETDCATVPP 


AIGSY
P31039 in FASTA format

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