ID   ALDH1_ENTHI             Reviewed;         529 AA.
AC   P30840;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-NOV-2008, entry version 43.
DE   RecName: Full=Aldehyde dehydrogenase 1;
DE            EC=1.2.1.3;
GN   Name=ALDH1;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Archamoebae; Entamoebidae; Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=94034173; PubMed=1340318;
RA   Samuelson J., Zhang W.W., Kumar A., Descoteaux S., Shen P.S.,
RA   Bailey G.;
RT   "Primary structures of alcohol and aldehyde dehydrogenase genes of
RT   Entamoeba histolytica.";
RL   Arch. Med. Res. 23:31-33(1992).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = an acid + NADH.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; L05667; AAA19741.1; -; Unassigned_DNA.
DR   HSSP; P11883; 1AD3.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC.
DR   GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR012394; Ald_DHase_NAD(P).
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   PANTHER; PTHR11699:SF15; ALDH; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN         1    529       Aldehyde dehydrogenase 1.
FT                                /FTId=PRO_0000056432.
FT   NP_BIND     251    256       NAD (By similarity).
FT   ACT_SITE    273    273       By similarity.
FT   ACT_SITE    307    307       By similarity.
SQ   SEQUENCE   529 AA;  59774 MW;  441DDA2E8DEA0961 CRC64;
     MEAYVLSLSD VLFNILFIGV CILSVLLLIS HALKYIIGDS KEKKLFNQRL EQIKNQQPLE
     PTKYQDIQTI CKTLKESYST NALRHLDARK EVLYCLYRMV LDNKQAISNA IREDLHRDVG
     MCVAEVNSVI HEINFLRKNL NKYLKRKQVP TVCAQLFGKS FVEREPYGCV CVISPWNFPA
     NLSLIPCAGA LACGNTVFLK MSKYSMATSK LIAELCDKYI PSEYLRCEYL TGREAIQECC
     SASFDYYFFT GSTYVGKLIN QAAAEKMVPA TLELGGKNPA IVDKSVNLKV AAKRIAWAKS
     INAGQICVCV DHVFVPRSIK NEFCEAVKNS FIKFFGEDQK KSEDFGRIIT KSAAKKMKEI
     IDQSDVYYGG EVDIENKYVQ PTILQNVKID DLCMKEEIFG PILPVIEYDT LDEVFEMVKQ
     HPNPLACYVF TEDNDMFEHV IANINSGAIY NNDSIVHLLN PNLPFGGNCQ SGIGCYHGKY
     TFDTFSRPRA VCNGHTSFDL SLKDWPFTSF QSWAVDRMAA SEIPVVSYL
//