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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 13543 / NRRL B-3784;
DOI=10.1021/bi00054a030; PubMed=8422400 [NCBI, ExPASy, EBI, Israel, Japan]
Xu X.,
Matsuno-Yagi A.,
Yagi T.;
"DNA sequencing of the seven remaining structural genes of the gene cluster encoding the energy-transducing NADH-quinone oxidoreductase of Paracoccus denitrificans.";
Biochemistry 32:968-981(1993).
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- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
- CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
- SUBUNIT: NDH-1 is composed of at least 14 different subunits, nqo1 to nqo14. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8, nqo10 to nqo14) embedded in the inner membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
- SIMILARITY: Belongs to the complex I subunit 4 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 513 AA [This is the length of the unprocessed precursor] |
Molecular weight: 56417 Da [This is the MW of the unprocessed precursor] |
CRC64: 8164DEACA20FE739 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTNLLSIITF LPIVAAIIMA LFLRGQDEAA ARNAKWLALL TTTATFVISL FVLFRFDPAN
70 80 90 100 110 120
TGFQFVEDHA WIMGVCYKMG VDGISVLFVL LTTFMMPLTI LSTWQVQDKV KEYMIAFLVL
130 140 150 160 170 180
EGLMIGVFTA LDLVLFYLFF EAGLIPMFLI IGIWGGKDRI YASFKFFLYT FLGSVLMLVA
190 200 210 220 230 240
MIAMYRMAGT TDIPTLLTFD FPSENFRLLG MTVVGGMQML LFLAFFASFA VKMPMWPVHT
250 260 270 280 290 300
WLPDAHVQAP TAGSVLLAAV LLKMGGYGFL RFSLPMFPVA SGVAQPYVFW LSAIAIVYTS
310 320 330 340 350 360
LVALAQSDMK KVIAYSSVAH MGYVTMGVFA ANQIGVDGAI FQMLSHGFIS GALFLCVGVI
370 380 390 400 410 420
YDRMHTREID AYGGLVNRMP AYAAVFMFFT MANVGLPGTS GFVGEFLTLM GVFRVDTWVA
430 440 450 460 470 480
LVATSGVILS AAYALWLYRR VTLGQLIKES LKSITDMTPR ERWVFIPLIA MTLILGVYPR
490 500 510
LVTDVTGPAV AALVQDYNQS QPAAPVATAQ ASH
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P29925 in FASTA format |
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