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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 13543 / NRRL B-3784;
DOI=10.1021/bi00054a030; PubMed=8422400 [NCBI, ExPASy, EBI, Israel, Japan]
Xu X.,
Matsuno-Yagi A.,
Yagi T.;
"DNA sequencing of the seven remaining structural genes of the gene cluster encoding the energy-transducing NADH-quinone oxidoreductase of Paracoccus denitrificans.";
Biochemistry 32:968-981(1993).
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- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
- CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
- SUBUNIT: NDH-1 is composed of at least 14 different subunits, nqo1 to nqo14. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8, nqo10 to nqo14) embedded in the inner membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
- SIMILARITY: Belongs to the complex I subunit 5 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 703 AA [This is the length of the unprocessed precursor] |
Molecular weight: 77706 Da [This is the MW of the unprocessed precursor] |
CRC64: 433993D4081B14CA [This is a checksum on the sequence] |
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10 20 30 40 50 60
MEKFVLFAPL IASLIAGLGW RAIGEKAAQY LTTGVLFLSC LISWYLFLSF DGVPRHIPVL
70 80 90 100 110 120
DWVVTGDFHA EWAIRLDRLT AIMLIVVTTV SALVHMYSLG YMAHDDNWTH DEHYKARFFA
130 140 150 160 170 180
YLSFFTFAML MLVTADNLLQ MFFGWEGVGV ASYLLIGFYY KKASANAAAM KAFIVNRVGD
190 200 210 220 230 240
FGFLLGIFGI YWLTGSVQFD EIFRQVPQLA QTEIDFLWRD WNAANLLGFL LFVGAMGKSA
250 260 270 280 290 300
QLLLHTWLPD AMEGPTPVSA LIHAATMVTA GVFLVCRMSP LYEFAPDAKN FIVIIGATTA
310 320 330 340 350 360
FFAATVGLVQ NDIKRVIAYS TCSQLGYMFV AAGVGVYSAA MFHLLTHAFF KAMLFLGAGS
370 380 390 400 410 420
VIHAMHHEQD MRNYGGLRKK IPLTFWAMMI GTFAITGVGI PLTHLGFAGF LSKDAIIESA
430 440 450 460 470 480
YAGSGYAFWL LVIAACFTSF YSWRLIFLTF YGKPRGDHHA HDHAHESPPV MTIPLGVLAI
490 500 510 520 530 540
GAVFAGMVWY GPFFGDHHKV TEYFHIAGAH HEAAEGEEAE HATAEAPVEH AVADTATAEG
550 560 570 580 590 600
EAAAEAEHAE IAAPVGGAIY MHPDNHIMDE AHHAPAWVKV SPFVAMVLGL ITAWTFYIAN
610 620 630 640 650 660
PSLPRRLAAH EPALYRFLLN KWYFDEIYEF IFVRPAKWLG RVLWKGGDGA VIDGTINGVA
670 680 690 700
MGLIPRLTRA AVRVQSGYLF HYAFAMVLGI VGLLIWVMMR GAH
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P29924 in FASTA format |
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