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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-15.
STRAIN=ATCC 13543 / NRRL B-3784;
DOI=10.1021/bi00145a009; PubMed=1637825 [NCBI, ExPASy, EBI, Israel, Japan]
Xu X.,
Matsuno-Yagi A.,
Yagi T.;
"Gene cluster of the energy-transducing NADH-quinone oxidoreductase of Paracoccus denitrificans: characterization of four structural gene products.";
Biochemistry 31:6925-6932(1992).
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- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
- CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
- SUBUNIT: NDH-1 is composed of at least 14 different subunits, nqo1 to nqo14. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8, nqo10 to nqo14) embedded in the inner membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein.
- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 412 AA [This is the length of the unprocessed precursor] |
Molecular weight: 46674 Da [This is the MW of the unprocessed precursor] |
CRC64: A3299D2E54011296 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MDGDIRKNSL DDGSMDALTG EQSIRNFNIN FGPQHPAAHG LLRMVLELDG EIVERADPHI
70 80 90 100 110 120
GLLHRGTEKL MESRTYLQNL PYLDRLDYVA PMNQEHAWCL AIERLTGTVI PRRASLIRVL
130 140 150 160 170 180
YSEIGRILNH LMGVTTGAMD VGALTPPLWG FEAREELMIF YERACGARLH AAYFRPGGVH
190 200 210 220 230 240
QDLPPDLLDD IEEWCERFPK LVDDLDTLLT ENRIFKQRLV DIGIVTEADA LDWGYTGVMV
250 260 270 280 290 300
RGSGLAWDLR RSQPYECYDE FDFQIPVGRN GDCYDRYLCR MAEMRESCKI MQQAVQKLRA
310 320 330 340 350 360
EPAGDVLARG KLTPPRRAEM KRDMESLIHH FKLYTEGFKV PAGEVYAAVE GPKGEFGVYL
370 380 390 400 410
VADGTNKPWR AKLRAPGFAH LQSIDWMSRG HMLADVPAII ATLDIVFGEV DR
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P29916 in FASTA format |
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