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UniProtKB/Swiss-Prot entry P29147

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BDH_RAT
Primary accession number P29147
Secondary accession number Q5U2Q2
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on July 5, 2005 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 68)
Name and origin of the protein
Protein name D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Precursor]
Synonyms BDH
EC 1.1.1.30
3-hydroxybutyrate dehydrogenase
Gene name
Name: Bdh1
Synonyms: Bdh
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=Sprague-Dawley;
TISSUE=Liver;
DOI=10.1021/bi00130a009; PubMed=1567834 [NCBI, ExPASy, EBI, Israel, Japan]
Churchill P., Hempel J., Romovacek H., Zhang W.W., Churchill S., Brennan M.;
"Primary structure of rat liver D-beta-hydroxybutyrate dehydrogenase from cDNA and protein analyses: a short-chain alcohol dehydrogenase.";
Biochemistry 31:3793-3799(1992).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M89902; AAB59684.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC085916; AAH85916.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A42345; A42345.
RefSeq NP_446447.2; -.
UniGene Rn.36635
3D structure databases
HSSP P14061; 1FDS. [HSSP ENTRY / PDB]
ModBase P29147.
Organism-specific databases
RGD 620131; Bdh1.
Gene expression databases
ArrayExpress P29147; -.
GermOnline ENSRNOG00000001736; Rattus norvegicus.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
BLOCKS P29147.
Genome annotation databases
Ensembl ENSRNOG00000001736; Rattus norvegicus. [Contig view]
GeneID 117099; -.
KEGG rno:117099; -.
NMPDR fig|10116.3.peg.7406; -.
Phylogenomic databases
HOVERGEN P29147; -.
Other
ProtoNet P29147.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Allosteric enzyme; Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    46  46     Mitochondrion. 
CHAIN   47   343  297     D-beta-hydroxybutyrate dehydrogenase, mitochondrial. PRO_0000031962
NP_BIND   59    83  25     NAD (By similarity). 
ACT_SITE   208   208        Proton acceptor (By similarity). 
BINDING   195   195        Substrate (By similarity). 
MOD_RES   132   132        N6-acetyllysine (By similarity). 
MOD_RES   275   275        N6-acetyllysine (By similarity). 
CONFLICT   90    91        DK -> EQ (in Ref. 1; AAB59684). 
Sequence information
Length: 343 AA [This is the length of the unprocessed precursor] Molecular weight: 38202 Da [This is the MW of the unprocessed precursor] CRC64: 6903D2ED27F2B055 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLAARLSRPL SQLPGKALSV CDRENGTRHT LLFYPASFSP DTRRTYTSQA DAASGKAVLV 

        70         80         90        100        110        120 
TGCDSGFGFS LAKHLHSKGF LVFAGCLLKD KGDAGVRELD SLKSDRLRTI QLNVCNSEEV 

       130        140        150        160        170        180 
EKAVETVRSG LKDPEKGMWG LVNNAGISTF GEVEFTSMET YKEVAEVNLW GTVRTTKSFL 

       190        200        210        220        230        240 
PLLRRAKGRV VNISSMLGRM ANPARSPYCI TKFGVEAFSD CLRYEMHPLG VKVSVVEPGN 

       250        260        270        280        290        300 
FIAATSLYSP ERIQAIAKKM WDELPEVVRK DYGKKYFDEK IAKMETYCNS GSTDTSSVIN 

       310        320        330        340 
AVTHALTAAT PYTRYHPMDY YWWLRMQVMT HFPGAISDKI YIH
P29147 in FASTA format

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