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UniProtKB/Swiss-Prot entry P28810

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MMSA_PSEAE
Primary accession number P28810
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name Methylmalonate-semialdehyde dehydrogenase [acylating]
Synonyms MMSDH
EC 1.2.1.27
Gene name
Name: mmsA
OrderedLocusNames: PA3570
From
Pseudomonas aeruginosa [TaxID: 287] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-30.
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
PubMed=1339433 [NCBI, ExPASy, EBI, Israel, Japan]
Steele M.I., Lorenz D., Hatter K., Park A., Sokatch J.R.;
"Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyisobutyrate dehydrogenase.";
J. Biol. Chem. 267:13585-13592(1992).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
[3]
 PROTEIN SEQUENCE OF 186-197 AND 335-351.
STRAIN=ATCC 33467 / type 1 smooth;
Liddor M.;
"Biofouling in water treatment systems: effect of membrane properties on biofilm formation.";
Thesis (2005), Ben-Gurion University, Israel.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M84911; AAA25891.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE004091; AAG06958.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B42902; B42902.
RefSeq NP_252260.1; -.
3D structure databases
HSSP P51977; 1BXS. [HSSP ENTRY / PDB]
ModBase P28810.
Enzyme and pathway databases
BioCyc MetaCyc:MON-11663; -.
PAER208964:PA3570-MON; -.
Organism-specific databases
PseudoCAP PA3570; -.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010061; MeMal-semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF27; MMSDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01722; MMSDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
BLOCKS P28810.
Genome annotation databases
GeneID 878814; -.
GenomeReviews AE004091_GR; PA3570.
KEGG pae:PA3570; -.
Phylogenomic databases
HOGENOM P28810; -.
Genome annotation databases
CMR P28810; PA3570.
Other
ProtoNet P28810.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   497  496     Methylmalonate-semialdehyde dehydrogenase [acylating]. PRO_0000056584
ACT_SITE   282   282        By similarity. 
Sequence information
Length: 497 AA [This is the length of the unprocessed precursor] Molecular weight: 53663 Da [This is the MW of the unprocessed precursor] CRC64: 3DB6BFC300AACA4D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSVPVRHLIA GAFVEGLGAQ RIPVSNPLDN STLAEIACAS AEQVEQAVAS ARETFASWKE 

        70         80         90        100        110        120 
TPVSERARVM LRYQALLKEH HDELAKIVSS ELGKTFEDAK GDVWRGIEVV EHACNVPSLL 

       130        140        150        160        170        180 
MGETVENVAR NIDTYSITQP LGVCVGITPF NFPAMIPLWM FPLAIACGNA FILKPSEQVP 

       190        200        210        220        230        240 
LTSVRLAELF LEAGAPKGVL QVVHGGKEQV DQLLKHPQVK AVSFVGSVAV GQYVYHTGTA 

       250        260        270        280        290        300 
HNKRVQSFAG AKNHMVIMPD ADKAQVISNL VGASVGAAGQ RCMAISVAVL VGAAREWIPE 

       310        320        330        340        350        360 
IRDALAKVRP GPWDDSGASY GPVINPQAKA RIERLIGQGV EEGAQLLLDG RGYKVEGYPD 

       370        380        390        400        410        420 
GNWVGPTLFA GVRPDMAIYR EEVFGPVLCL AEVDSLEQAI RLINESPYGN GTSIFTSSGA 

       430        440        450        460        470        480 
AARTFQHHIE VGQVGINIPI PVPLPFFSFT GWKGSFYGDL HAYGKQGVRF YTETKTVTAR 

       490 
WFDSDSVAGT NFSIQMR
P28810 in FASTA format

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