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UniProtKB/Swiss-Prot entry P28798


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GRN_MOUSE
Primary accession number P28798
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on October 1, 1994 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 64)
Name and origin of the protein
Protein name Granulins [Precursor]
Synonyms Proepithelin
PEPI
PC cell-derived growth factor
PCDGF
Contains Acrogranin
Granulin-1
Granulin-2
Granulin-3
Granulin-4
Granulin-5
Granulin-6
Granulin-7
Gene name
Name: Grn
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE.
DOI=10.1016/0014-5793(93)81544-A; PubMed=8482392 [NCBI, ExPASy, EBI, Israel, Japan]
Baba T., Nemoto H., Watanabe K., Arai Y., Gerton G.L.;
"Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin).";
FEBS Lett. 322:89-94(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Kidney;
PubMed=1618805 [NCBI, ExPASy, EBI, Israel, Japan]
Plowman G.D., Green J.M., Neubauer M.G., Buckley S.D., McDonald V.L., Todaro G.J., Shoyab M.;
"The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.";
J. Biol. Chem. 267:13073-13078(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8471244 [NCBI, ExPASy, EBI, Israel, Japan]
Baba T., Hoff H.B. III, Nemoto H., Lee H., Orth J., Arai Y., Gerton G.L.;
"Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells.";
Mol. Reprod. Dev. 34:233-243(1993).
[4]
PROTEIN SEQUENCE OF 18-32; 116-127; 152-164; 198-226; 228-233; 259-280; 297-304 AND 421-430, FUNCTION, GLYCOSYLATION, AND SUBCELLULAR LOCATION.
PubMed=8496151 [NCBI, ExPASy, EBI, Israel, Japan]
Zhou J., Gao G., Crabb J.W., Serrero G.;
"Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line.";
J. Biol. Chem. 268:10863-10869(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D16195; BAA03736.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M86736; AAA37191.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X62321; CAA44197.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C38128; C38128.
RefSeq NP_032201.1; -.
UniGene Mm.1568
3D structure databases
HSSP P28799; 1G26. [HSSP ENTRY / PDB]
ModBase P28798.
Organism-specific databases
MGI MGI:95832; Grn.
Gene expression databases
CleanEx MM_GRN; -.
GermOnline ENSMUSG00000034708; Mus musculus.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from direct assay from MGI).
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from MGI).
GO:0001835; Biological process: blastocyst hatching (inferred from direct assay from MGI).
GO:0007566; Biological process: embryo implantation (inferred from direct assay from MGI).
GO:0050679; Biological process: positive regulation of epithelial cell proliferation (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR015874; 4-disulphide_core.
IPR000118; Granulin.
Graphical view of domain structure.
Pfam PF00396; Granulin; 7.
Pfam graphical view of domain structure.
PRINTS PR00003; 4DISULPHCORE.
SMART SM00277; GRAN; 7.
SMART graphical view of domain structure.
PROSITE PS00799; GRANULINS; 7.
BLOCKS P28798.
Genome annotation databases
Ensembl ENSMUSG00000034708; Mus musculus. [Contig view]
GeneID 14824; -.
KEGG mmu:14824; -.
Phylogenomic databases
HOVERGEN P28798; -.
Other
SOURCE Grn; Mus musculus.
ProtoNet P28798.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytokine; Direct protein sequencing; Glycoprotein; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     17  17      
CHAIN   18    589  572     Acrogranin. PRO_0000012702
PEPTIDE   ?58   ?113        Granulin-1. PRO_0000012703
PEPTIDE   ?122   ?178        Granulin-2. PRO_0000012704
PEPTIDE   205    260  56     Granulin-3. PRO_0000012705
PEPTIDE   280    334  55     Granulin-4. PRO_0000012706
PEPTIDE   362   ?414        Granulin-5. PRO_0000012707
PEPTIDE   440   ?493        Granulin-6. PRO_0000012708
PEPTIDE   ?517   ?568        Granulin-7. PRO_0000012709
CARBOHYD   38     38        N-linked (GlcNAc...) (Potential). 
CARBOHYD   263    263        N-linked (GlcNAc...) (Potential). 
CARBOHYD   373    373        N-linked (GlcNAc...) (Potential). 
CARBOHYD   526    526        N-linked (GlcNAc...) (Potential). 
CONFLICT   251    251        V -> L (in Ref. 3; AAA37191). 
CONFLICT   254    254        L -> V (in Ref. 3; AAA37191). 
CONFLICT   261    263        SKN -> YD (in Ref. 4; AA sequence). 
CONFLICT   350    350        L -> R (in Ref. 2; CAA44197). 
CONFLICT   402    403        CP -> SA (in Ref. 3; AAA37191). 
Sequence information
Length: 589 AA [This is the length of the unprocessed precursor] Molecular weight: 63458 Da [This is the MW of the unprocessed precursor] CRC64: 1DE8229C413CB787 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MWVLMSWLAF AAGLVAGTQC PDGQFCPVAC CLDQGGANYS CCNPLLDTWP RITSHHLDGS 

        70         80         90        100        110        120 
CQTHGHCPAG YSCLLTVSGT SSCCPFSKGV SCGDGYHCCP QGFHCSADGK SCFQMSDNPL 

       130        140        150        160        170        180 
GAVQCPGSQF ECPDSATCCI MVDGSWGCCP MPQASCCEDR VHCCPHGASC DLVHTRCVSP 

       190        200        210        220        230        240 
TGTHTLLKKF PAQKTNRAVS LPFSVVCPDA KTQCPDDSTC CELPTGKYGC CPMPNAICCS 

       250        260        270        280        290        300 
DHLHCCPQDT VCDLIQSKCL SKNYTTDLLT KLPGYPVKEV KCDMEVSCPE GYTCCRLNTG 

       310        320        330        340        350        360 
AWGCCPFAKA VCCEDHIHCC PAGFQCHTEK GTCEMGILQV PWMKKVIAPL RLPDPQILKS 

       370        380        390        400        410        420 
DTPCDDFTRC PTNNTCCKLN SGDWGCCPIP EAVCCSDNQH CCPQGFTCLA QGYCQKGDTM 

       430        440        450        460        470        480 
VAGLEKIPAR QTTPLQIGDI GCDQHTSCPV GQTCCPSLKG SWACCQLPHA VCCEDRQHCC 

       490        500        510        520        530        540 
PAGYTCNVKA RTCEKDVDFI QPPVLLTLGP KVGNVECGEG HFCHDNQTCC KDSAGVWACC 

       550        560        570        580 
PYLKGVCCRD GRHCCPGGFH CSARGTKCLR KKIPRWDMFL RDPVPRPLL 

P28798 in FASTA format

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View entry in raw text format (no links)
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