ID   ADH1A_MACMU             Reviewed;         375 AA.
AC   P28469;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   04-NOV-2008, entry version 55.
DE   RecName: Full=Alcohol dehydrogenase 1A;
DE            EC=1.1.1.1;
DE   AltName: Full=Alcohol dehydrogenase subunit alpha;
GN   Name=ADH1A; Synonyms=ADH1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   MEDLINE=92316940; PubMed=1618764;
RA   Light D.R., Dennis M.S., Forsythe I.J., Liu C.C., Green D.W.,
RA   Kratzer D., Plapp B.V.;
RT   "Alpha-isoenzyme of alcohol dehydrogenase from monkey liver. Cloning,
RT   expression, mechanism, coenzyme, and substrate specificity.";
RL   J. Biol. Chem. 267:12592-12599(1992).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone +
CC       NADH.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC   -!- SUBUNIT: Homodimer or heterodimer of closely related subunits (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; M81807; AAA36830.1; -; mRNA.
DR   PIR; I55359; I55359.
DR   RefSeq; NP_001036230.1; -.
DR   UniGene; Mmu.3289; -.
DR   HSSP; P00325; 1HDZ.
DR   SMR; P28469; 2-375.
DR   Ensembl; ENSMMUG00000018738; Macaca mulatta.
DR   GeneID; 707682; -.
DR   KEGG; mcc:707682; -.
DR   HOVERGEN; P28469; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004022; F:alcohol dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; AlcDHase_GroES-like.
DR   InterPro; IPR002085; AlcDHase_SF_Zn.
DR   InterPro; IPR013149; AlcDHase_Zn-bd.
DR   InterPro; IPR002328; AlcDHase_Zn_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    375       Alcohol dehydrogenase 1A.
FT                                /FTId=PRO_0000160659.
FT   METAL        47     47       Zinc 1; catalytic (By similarity).
FT   METAL        68     68       Zinc 1; catalytic (By similarity).
FT   METAL        98     98       Zinc 2 (By similarity).
FT   METAL       101    101       Zinc 2 (By similarity).
FT   METAL       104    104       Zinc 2 (By similarity).
FT   METAL       112    112       Zinc 2 (By similarity).
FT   METAL       175    175       Zinc 1; catalytic (By similarity).
FT   MOD_RES       2      2       N-acetylserine (By similarity).
SQ   SEQUENCE   375 AA;  39913 MW;  8B0DDC03673AA8DA CRC64;
     MSTAGKVIKC KAAVLWEVMK PFSIEDVEVA PPKAYEVRIK MVTVGICGTD DHVVSGTMVT
     PLPVILGHEA AGIVESVGEG VTTVEPGDKV IPLALPQCGK CRICKTPERN YCLKNDVSNP
     RGTLQDGTSR FTCRGKPIHH FLGVSTFSQY TVVDENAVAK IDAASPMEKV CLIGCGFSTG
     YGSAVKVAKV TPGSTCAVFG LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE
     CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ
     NLSINPMLLL TGRTWKGAVY GGFKSKEDIP KLVADFMAKK FSLDALITHV LPFEKINEGF
     DLLRSGKSIR TILTF
//