[1]	NUCLEOTIDE SEQUENCE. DOI=10.1016/0378-1119(93)90119-N; PubMed=8428654 [NCBI, ExPASy, EBI, Israel, Japan] Genez A.L., Staraci L.C., Alexander D.C., Rejda V.M., Williamson V.M., Chase T. Jr., Williams B.G.; "Isolation of a tomato alcohol dehydrogenase 2-encoding cDNA using phage-promoted antibody screening of a plasmid cDNA library."; Gene 123:157-164(1993).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. STRAIN=cv. De Ruiter 83G38; DOI=10.1007/BF00040690; PubMed=7811967 [NCBI, ExPASy, EBI, Israel, Japan] Longhurst T., Lee E., Hinde R., Brady C., Speirs J.; "Structure of the tomato Adh2 gene and Adh2 pseudogenes, and a study of Adh2 gene expression in fruit."; Plant Mol. Biol. 26:1073-1084(1994).
[3]	NUCLEOTIDE SEQUENCE [MRNA] OF 252-380. STRAIN=cv. Orlando; DOI=10.1016/0014-5793(91)81379-M; PubMed=1765164 [NCBI, ExPASy, EBI, Israel, Japan] van der Straeten D., Pousada R.A.R., Gielen J., van Montagu M.; "Tomato alcohol dehydrogenase. Expression during fruit ripening and under hypoxic conditions."; FEBS Lett. 295:39-42(1991).

Comments

CATALYTIC ACTIVITY: An alcohol + NAD⁺ = an aldehyde or ketone + NADH.
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M86724; AAA34133.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X77233; CAA54450.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X60600; CAA43055.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S51826; S51826.

UniGene

Les.19427

3D structure databases

HSSP

P11766; 1M6H. [HSSP ENTRY / PDB]

ModBase

P28032.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS00059; ADH_ZINC; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 380`	`380`	`Alcohol dehydrogenase 2.`	`PRO_0000160702`
`METAL`	`48 48`		`Zinc 1; catalytic (By similarity).`
`METAL`	`70 70`		`Zinc 1; catalytic (By similarity).`
`METAL`	`100 100`		`Zinc 2 (By similarity).`
`METAL`	`103 103`		`Zinc 2 (By similarity).`
`METAL`	`106 106`		`Zinc 2 (By similarity).`
`METAL`	`114 114`		`Zinc 2 (By similarity).`
`METAL`	`178 178`		`Zinc 1; catalytic (By similarity).`

Sequence information

Length: 380 AA [This is the length of the unprocessed precursor]

Molecular weight: 41040 Da [This is the MW of the unprocessed precursor]

CRC64: D5B123DF9DE28027 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSTTVGQVIR CKAAVAWEAG KPLVMEEVDV APPQKMEVRL KILYTSLCHT DVYFWEAKGQ 

        70         80         90        100        110        120 
NPVFPRILGH EAAGIVESVG EGVTDLAPGD HVLPVFTGEC KDCAHCKSEE SNMCSLLRIN 

       130        140        150        160        170        180 
TDRGVMLNDG KSRFSINGNP IYHFVGTSTF SEYTVVHVGC VAKINPLAPL DKVCVLSCGI 

       190        200        210        220        230        240 
STGLGASLNV AKPTKGSSVA IFGLGAVGLA AAEGARIAGA SRIIGVDLNA SRFEQAKKFG 

       250        260        270        280        290        300 
VTEFVNPKDY SKPVQEVIAE MTDGGVDRSV ECTGHIDAMI SAFECVHDGW GVAVLVGVPH 

       310        320        330        340        350        360 
KEAVFKTHPL NFLNERTLKG TFFGNYKPRS DIPCVVEKYM NKELELEKFI THTLPFAEIN 

       370        380 
KAFDLMLKGE GLRCIITMAD

P28032 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools