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UniProtKB/Swiss-Prot entry P27479

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LOX12_BOVIN
Primary accession number P27479
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 67)
Name and origin of the protein
Protein name Arachidonate 12-lipoxygenase, 12S-type
Synonyms 12-LOX
EC 1.13.11.31
Gene name
Name: ALOX12
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Tracheal epithelium;
PubMed=1539676 [NCBI, ExPASy, EBI, Israel, Japan]
de Marzo N., Sloan D.L., Dicharry S., Highland E., Sigal E.;
"Cloning and expression of an airway epithelial 12-lipoxygenase.";
Am. J. Physiol. 262:L198-L207(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M81320; AAA30346.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M62516; AAC41614.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S96247; AAB21522.2; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S32825; S32825.
RefSeq NP_776926.1; -.
UniGene Bt.2598
3D structure databases
HSSP P12530; 1LOX. [HSSP ENTRY / PDB]
SMR P27479; 2-663.
ModBase P27479.
Ontologies
GO
GO:0004052; Molecular function: arachidonate 12-lipoxygenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR000907; LipOase.
IPR013819; LipOase_C.
IPR001024; LipOase_LH2.
IPR001885; LipOase_mml.
Graphical view of domain structure.
Gene3D G3DSA:2.60.60.20; Lipase_LipOase; 1.
PANTHER PTHR11771; LipOase; 1.
Pfam PF00305; Lipoxygenase; 1.
PF01477; PLAT; 1.
Pfam graphical view of domain structure.
PRINTS PR00087; LIPOXYGENASE.
PR00467; MAMLPOXGNASE.
SMART SM00308; LH2; 1.
SMART graphical view of domain structure.
PROSITE PS00711; LIPOXYGENASE_1; 1.
PS00081; LIPOXYGENASE_2; 1.
PS50095; PLAT; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P27479.
Genome annotation databases
Ensembl ENSBTAG00000011990; Bos taurus. [Contig view]
GeneID 282139; -.
KEGG bta:282139; -.
Phylogenomic databases
HOVERGEN P27479; -.
Other
ProtoNet P27479.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Dioxygenase; Iron; Leukotriene biosynthesis; Metal-binding; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   663  662     Arachidonate 12-lipoxygenase, 12S-type. PRO_0000220681
DOMAIN   2   115  114     PLAT. 
METAL   361   361        Iron (catalytic) (By similarity). 
METAL   366   366        Iron (catalytic) (By similarity). 
METAL   541   541        Iron (catalytic) (By similarity). 
METAL   663   663        Iron (via carboxylate) (catalytic) (By similarity). 
Sequence information
Length: 663 AA [This is the length of the unprocessed precursor] Molecular weight: 75041 Da [This is the MW of the unprocessed precursor] CRC64: 58063351F14E15D4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGLYRVRVST GSSFCAGSNN QVHLWLVGEH GEAALGWAVR PARGKEVEFQ VDVSEYLGRL 

        70         80         90        100        110        120 
LFVKLRKRHL LSDDAWFCNW ISVQGPGASG NEFRFPCYRW VEGDGILSLP EGTGRTVVDD 

       130        140        150        160        170        180 
PQGLFKKHRE EELAERRKLY RWGNWKDGLI LNIAGATIND LPVDERFLED KRIDFEASLT 

       190        200        210        220        230        240 
KGLADLAIKD SLNILTCWKS LDDFNRIFWC GQSKLAERVR DSWKEDALFG YQFLNGTNPM 

       250        260        270        280        290        300 
LLRRSVRLPA RLEFPPGMGE LQAELEKELQ QGTLFEADFS LLMGIKANVI LCTQQYVAAP 

       310        320        330        340        350        360 
LVMLKLQPDG KLLPMAIQLQ LPHKGSPPPP LFLPTDPPMT WLLAKCWVRS SDFQLHELHS 

       370        380        390        400        410        420 
HLLRGHLVAE VIAVATMRCL PSIHPMFKLL IPHLRYTMEI NIRARTGLVS DSGVFDQVVS 

       430        440        450        460        470        480 
TGGGGHVELL QRAGAFLTYS SFCPPDDLAD RGLLGVKSSF YAQDALRLWE ILSRYVEGIV 

       490        500        510        520        530        540 
SLHYKTDESV RDDIELQAWC RDITEIGLLG AQDRGFPVTL QSKDQLCHFV TMCIFTCTGQ 

       550        560        570        580        590        600 
HSSTHLGQLD WYSWVPNAPC TMRLPPPTTK DVTLEKVMAT LPNFHQASLQ MSITWQLGRR 

       610        620        630        640        650        660 
QPIMVALGQH EEEYFSGPEP KAVLKKFREE LAALEKDIEI RNAQLDWPYE YLRPSLVENS 


VAI
P27479 in FASTA format

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