[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1007/BF00272157; PubMed=1833618 [NCBI, ExPASy, EBI, Israel, Japan] Cleton-Jansen A.-M., Dekker S., van de Putte P., Goosen N.; "A single amino acid substitution changes the substrate specificity of quinoprotein glucose dehydrogenase in Gluconobacter oxydans."; Mol. Gen. Genet. 229:206-212(1991).
[2]	SEQUENCE REVISION TO 213. Goosen N.; Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=621H; DOI=10.1038/nbt1062; PubMed=15665824 [NCBI, ExPASy, EBI, Israel, Japan] Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.; "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."; Nat. Biotechnol. 23:195-200(2005).

Comments

CATALYTIC ACTIVITY: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol.
COFACTOR: PQQ.
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein; Periplasmic side.
MISCELLANEOUS: The P1 form can oxidize only D-glucose, while the P2 form can also oxidize maltose. The sequence of P1 form is shown here.
SIMILARITY: Belongs to the bacterial PQQ dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X62710; CAA44594.1; ALT_SEQ; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000009; AAW60048.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S17716; QPKEX.

RefSeq

YP_190704.1; -.

3D structure databases

ModBase

P27175.

Enzyme and pathway databases

BioCyc

GOXY290633:GOX0265-MON; -.

Family and domain databases

InterPro

IPR017511; PQQ_mem_DH.
IPR002372; PQQ_repeat.
IPR011047; Quino_AlcDHase-like.
IPR001479; Quinoprotein_DHase_PQQ_bac_CS.
Graphical view of domain structure.

Gene3D

G3DSA:2.140.10.10; Quinoprotein_alc_DH-like; 1.

Pfam

PF01011; PQQ; 6.
Pfam graphical view of domain structure.

SMART

SM00564; PQQ; 3.
SMART graphical view of domain structure.

PROSITE

PS00363; BACTERIAL_PQQ_1; 1.
PS00364; BACTERIAL_PQQ_2; 1.

BLOCKS

P27175.

Genome annotation databases

GeneID

3248643; -.

GenomeReviews

CP000009_GR; GOX0265.

KEGG

gox:GOX0265; -.

NMPDR

fig|290633.1.peg.249; -.

Phylogenomic databases

HOGENOM

P27175; -.

Genome annotation databases

CMR

P27175; GOX0265.

Other

ProtoNet

P27175.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell inner membrane; Cell membrane; Complete proteome; Membrane; Oxidoreductase; Periplasm; PQQ; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 33`	`33`	`Potential.`
`CHAIN`	`34 808`	`775`	`Quinoprotein glucose dehydrogenase.`	`PRO_0000025558`
`TRANSMEM`	`35 54`	`20`	`Potential.`
`TRANSMEM`	`59 76`	`18`	`Potential.`
`TRANSMEM`	`94 108`	`15`	`Potential.`
`TRANSMEM`	`123 138`	`16`	`Potential.`
`ACT_SITE`	`470 470`		`Proton acceptor (Potential).`
`VARIANT`	`788 788`	`1`	`H -> N (in P2 form).`
`CONFLICT`	`4 4`		`T -> I (in Ref. 1; CAA44594).`
`CONFLICT`	`8 8`		`G -> R (in Ref. 1; CAA44594).`
`CONFLICT`	`110 123`		`QIGGTRTTVLPLAG -> ARSVARGRPSCRSP (in Ref. 1).`
`CONFLICT`	`146 146`		`D -> E (in Ref. 1; CAA44594).`
`CONFLICT`	`188 188`		`S -> T (in Ref. 1; CAA44594).`
`CONFLICT`	`213 213`		`A -> Q (in Ref. 1).`
`CONFLICT`	`277 277`		`T -> M (in Ref. 1; CAA44594).`
`CONFLICT`	`291 292`		`RI -> DS (in Ref. 1; CAA44594).`
`CONFLICT`	`395 395`		`D -> E (in Ref. 1; CAA44594).`
`CONFLICT`	`415 415`		`R -> A (in Ref. 1; CAA44594).`
`CONFLICT`	`472 473`		`DV -> EL (in Ref. 1; CAA44594).`
`CONFLICT`	`635 636`		`KD -> EN (in Ref. 1; CAA44594).`

Sequence information

Length: 808 AA [This is the length of the unprocessed precursor]

Molecular weight: 87335 Da [This is the MW of the unprocessed precursor]

CRC64: 6FFF304215A63D29 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSTTSRPGLW ALITAAVFAL CGAILTVGGA WVAAIGGPLY YVILGLALLA TAFLSFRRNP 

        70         80         90        100        110        120 
AALYLFAVVV FGTVIWELTV VGLDIWALIP RSDIVIILGI WLLLPFVSRQ IGGTRTTVLP 

       130        140        150        160        170        180 
LAGAVGVAVL ALFASLFTDP HDISGDLPTQ IANASPADPD NVPASEWHAY GRTQAGDRWS 

       190        200        210        220        230        240 
PLNQINASNV SNLKVAWHIH TKDMMNSNDP GEATNEATPI EFNNTLYMCS LHQKLFAVDG 

       250        260        270        280        290        300 
ATGNVKWVYD PKLQINPGFQ HLTCRGVSFH ETPANATDSD GNPAPTDCAK RIILPVNDGR 

       310        320        330        340        350        360 
LVEVDADTGK TCSGFGNNGE IDLRVPNQPY TTPGQYEPTS PPVITDKLII ANSAITDNGS 

       370        380        390        400        410        420 
VKQASGATQA FDVYTGKRVW VFDASNPDPN QLPDDSHPVF HPNSPNSWIV SSYDRNLNLV 

       430        440        450        460        470        480 
YIPMGVGTPD QWGGDRTKDS ERFAPGIVAL NADTGKLAWF YQTVHHDLWD MDVPSQPSLV 

       490        500        510        520        530        540 
DVTQKDGTLV PAIYAPTKTG DIFVLDRRTG KEIVPAPETP VPQGAAPGDH TSPTQPMSQL 

       550        560        570        580        590        600 
TLRPKNPLND SDIWGGTIFD QMFCSIYFHT LRYEGPFTPP SLKGSLIFPG DLGMFEWGGL 

       610        620        630        640        650        660 
AVDPQRQVAF ANPISLPFVS QLVPRGPGNP LWPEKDAKGT GGETGLQHNY GIPYAVNLHP 

       670        680        690        700        710        720 
FLDPVLLPFG IKMPCRTPPW GYVAGIDLKT NKVVWQHRNG TLRDSMYGSS LPIPLPPIKI 

       730        740        750        760        770        780 
GVPSLGGPLS TAGNLGFLTA SMDYYIRAYN LTTGKVLWQD RLPAGAQATP ITYAINGKQY 

       790        800 
IVTYAGGHNS FPTRMGDDII AYALPDQK

P27175 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools