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UniProtKB/Swiss-Prot entry P27138


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TFDB_RALEJ
Primary accession number P27138
Secondary accession number Q46M70
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on August 1, 1992 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name 2,4-dichlorophenol 6-monooxygenase
Synonyms EC 1.14.13.20
2,4-dichlorophenol hydroxylase
2,4-DCP hydroxylase
Gene name
Name: tfdB
Synonyms: tfdBI
OrderedLocusNames: Reut_D6462
From
Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [TaxID: 264198] [HAMAP proteome]
Encoded on Plasmid pJP4; Plasmid pReut1.
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Cupriavidus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PLASMID=pJP4;
PubMed=2185214 [NCBI, ExPASy, EBI, Israel, Japan]
Perkins E.J., Gordon M.P., Caceres O., Lurquin P.F.;
"Organization and sequence analysis of the 2,4-dichlorophenol hydroxylase and dichlorocatechol oxidative operons of plasmid pJP4.";
J. Bacteriol. 172:2351-2359(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PLASMID=pJP4;
DOI=10.1111/j.1462-2920.2004.00596.x; PubMed=15186344 [NCBI, ExPASy, EBI, Israel, Japan]
Trefault N., De la Iglesia R., Molina A.M., Manzano M., Ledger T., Perez-Pantoja D., Sanchez M.A., Stuardo M., Gonzalez B.;
"Genetic organization of the catabolic plasmid pJP4 from Ralstonia eutropha JMP134 (pJP4) reveals mechanisms of adaptation to chloroaromatic pollutants and evolution of specialized chloroaromatic degradation pathways.";
Environ. Microbiol. 6:655-668(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PLASMID=pReut1;
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.;
"Complete sequence of plasmid 1 of Ralstonia eutropha JMP134.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M35097; AAA98266.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY365053; AAR31035.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000093; AAZ65760.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E35255; E35255.
RefSeq YP_025383.1; -.
YP_293617.1; -.
3D structure databases
ModBase P27138.
Enzyme and pathway databases
BioCyc REUT264198:REUT_D6462-MON; -.
Ontologies
GO
GO:0018666; Molecular function: 2,4-dichlorophenol 6-monooxygenase activity (non-traceable author statement from UniProtKB).
GO:0046300; Biological process: 2,4-dichlorophenoxyacetic acid catabolic process (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR002938; mOase_FAD_bd.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR003042; Rng_hydrolase.
Graphical view of domain structure.
Pfam PF01494; FAD_binding_3; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00411; PNDRDTASEI.
PR00420; RNGMNOXGNASE.
BLOCKS P27138.
Genome annotation databases
GeneID 2847394; -.
3607953; -.
GenomeReviews CP000093_GR; Reut_D6462.
KEGG reu:Reut_D6462; -.
Phylogenomic databases
HOGENOM P27138; -.
Genome annotation databases
CMR P27138; Reut_D6462.
Other
ProtoNet P27138.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Aromatic hydrocarbons catabolism; Complete proteome; FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase; Plasmid.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   598  598     2,4-dichlorophenol 6-monooxygenase. PRO_0000214049
NP_BIND   8    37  30     FAD (Potential). 
NP_BIND   301   311  11     FAD (Potential). 
Sequence information
Length: 598 AA [This is the length of the unprocessed precursor] Molecular weight: 65380 Da [This is the MW of the unprocessed precursor] CRC64: A1E552E5A34B832F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MALTIETDVL VVGTGPAGAS AGALLARYGV RTMLINKYNW TAPTPRAHIT NQRTMEILRD 

        70         80         90        100        110        120 
LGLEAEARLY AAPNDLMGEN TICASLAGEE FGRIRTWGTD VRRRADYDEC SPTSMCDLPQ 

       130        140        150        160        170        180 
NYLEPILVKS AALDGCKVRF DTEYLGHEQD ADGVSSRLRD RLNGEEFTVR SKYLIGADGA 

       190        200        210        220        230        240 
NSRVVSDLDL PLEGTMGKSG SINLLFEADL DRYVAHRPSV LYWVIQPGSD IGGLGIGVVR 

       250        260        270        280        290        300 
MVRPWNKWLA IWGYDVEQGP PEISESFARR IVHNLIGDDS VPLKIEGIST WTVNDMYATR 

       310        320        330        340        350        360 
LQQGRVFCAG DAVHRHPPTN GLGSNTSIQD SFNLAWKIAM VLNGTADESL LDTYTIERAP 

       370        380        390        400        410        420 
IAKQVVCRAN KSLEDFPPIA MALGLPQAKS ADEMKSNMAR RKEPGPEAQA QRTRLREAIA 

       430        440        450        460        470        480 
GTNYVYNAHG VEMNQRYDSP AIVADNSPDE VFRDVELYHQ ASTRPGAPMP HVWVYASGDG 

       490        500        510        520        530        540 
HRISTKDLCG KGNFTLFTGI GGAAWQDAAA AVSRQLGVAV TVRIIGPGQA YEDHYGDFAR 

       550        560        570        580        590 
ISEIIDTGAI LVRPDFHVAY RATSLPADAA GDLVSAMRRI LGRQSERSSA LRVTSRAI 

P27138 in FASTA format

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