[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. DOI=10.1093/nar/19.12.3454; PubMed=2062660 [NCBI, ExPASy, EBI, Israel, Japan] Taylor G.A., Lai W.S., Oakey R.J., Seldin M.F., Shows T.B., Eddy R.L. Jr., Blackshear P.J.; "The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes."; Nucleic Acids Res. 19:3454-3454(1991).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-37; PHE-259 AND PHE-324. Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Chambers S.W., Schackwitz W.S., Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Pancreas; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Has been experimentally shown to be able to bind zinc.
INTERACTION:
Q9NPI6:DCP1A; NbExp=1; IntAct=EBI-374248, EBI-374238;
Q8IU60-1:DCP2; NbExp=1; IntAct=EBI-374248, EBI-521586;
Q96F86:EDC3; NbExp=1; IntAct=EBI-374248, EBI-997311;
Q96B26:EXOSC8; NbExp=1; IntAct=EBI-374248, EBI-371922;
Q9HAU5:UPF2; NbExp=1; IntAct=EBI-374248, EBI-372073;
SUBCELLULAR LOCATION: Nucleus.
INDUCTION: By stimulation with various mitogens.
SIMILARITY: Contains 2 C3H1-type zinc fingers.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M92843; AAA58489.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M92844; AAC37600.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M63625; AAA61240.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY771351; AAV28731.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009693; AAH09693.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S34427; S34427.

NP_003398.1; -.

3D structure databases

HSSP

P22893; 1M9O. [HSSP ENTRY / PDB]

SMR

P26651; 102-170.

ModBase

P26651.

Protein-protein interaction databases

IntAct

P26651; -.

PTM databases

PhosphoSite

P26651; -.

Polymorphism databases

NIEHS-SNPs

ZFP36.

Organism-specific databases

HGNC:12862; ZFP36.

HPA006009; -.

190700; gene. [NCBI / EBI]

PharmGKB

PA37451; -.

GeneCards

P26651.

Gene expression databases

ArrayExpress

P26651; -.

CleanEx

HS_ZFP36; -.

GermOnline

ENSG00000128016; Homo sapiens.

Ontologies

GO:0005829;	Cellular component: cytosol (inferred from direct assay from MGI).
GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003729;	Molecular function: mRNA binding (inferred from direct assay from MGI).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0003727;	Molecular function: single-stranded RNA binding (traceable author statement from ProtInc).
GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000571; Znf_CCCH.
Graphical view of domain structure.

Pfam

PF00642; zf-CCCH; 2.
Pfam graphical view of domain structure.

SMART

SM00356; ZnF_C3H1; 2.
SMART graphical view of domain structure.

PROSITE

PS50103; ZF_C3H1; 2.
PROSITE graphical view of domain structure (profiles).

ProtoNet

P26651.

Genome annotation databases

Ensembl

ENSG00000128016; Homo sapiens. [Contig view]

GeneID

7538; -.

KEGG

hsa:7538; -.

Phylogenomic databases

HOGENOM

P26651; -.

HOVERGEN

P26651; -.

Other

NextBio

29497; -.

SOURCE

ZFP36; Homo sapiens.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Repeat; Zinc; Zinc-finger.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 326`	`326`	`Tristetraproline.`	`PRO_0000089163`
`REPEAT`	`71 75`	`5`	`P-P-P-P-G.`
`REPEAT`	`198 202`	`5`	`P-P-P-P-G.`
`REPEAT`	`219 223`	`5`	`P-P-P-P-G.`
`ZN_FING`	`103 131`	`29`	`C3H1-type 1.`
`ZN_FING`	`141 169`	`29`	`C3H1-type 2.`
`MOD_RES`	`60 60`		`Phosphoserine (By similarity).`
`MOD_RES`	`88 88`		`Phosphoserine (By similarity).`
`MOD_RES`	`90 90`		`Phosphoserine (By similarity).`
`MOD_RES`	`93 93`		`Phosphoserine (By similarity).`
`MOD_RES`	`186 186`		`Phosphoserine (By similarity).`
`MOD_RES`	`257 257`		`Phosphothreonine (By similarity).`
`MOD_RES`	`323 323`		`Phosphoserine (By similarity).`
`VARIANT`	`37 37`	`1`	`P -> S.`	`VAR_021064`
`VARIANT`	`259 259`	`1`	`I -> F.`	`VAR_021065`
`VARIANT`	`324 324`	`1`	`V -> F.`	`VAR_021066`

Sequence information

Length: 326 AA [This is the length of the unprocessed precursor]

Molecular weight: 34003 Da [This is the MW of the unprocessed precursor]

CRC64: DDD9AD950AF7AF98 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDLTAIYESL LSLSPDVPVP SDHGGTESSP GWGSSGPWSL SPSDSSPSGV TSRLPGRSTS 

        70         80         90        100        110        120 
LVEGRSCGWV PPPPGFAPLA PRLGPELSPS PTSPTATSTT PSRYKTELCR TFSESGRCRY 

       130        140        150        160        170        180 
GAKCQFAHGL GELRQANRHP KYKTELCHKF YLQGRCPYGS RCHFIHNPSE DLAAPGHPPV 

       190        200        210        220        230        240 
LRQSISFSGL PSGRRTSPPP PGLAGPSLSS SSFSPSSSPP PPGDLPLSPS AFSAAPGTPL 

       250        260        270        280        290        300 
ARRDPTPVCC PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE 

       310        320 
AGVFAPPQPV AAPRRLPIFN RISVSE

P26651 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools