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UniProtKB/Swiss-Prot entry P23991

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_CHICK
Primary accession number P23991
Secondary accession numbers None
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonyms ADH-1
EC 1.1.1.1
Alcohol dehydrogenase I
Gene name
Name: ADH1
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=2269284 [NCBI, ExPASy, EBI, Israel, Japan]
Estonius M., Karlsson C., Fox E.A., Hoeoeg J.-O., Holmquist B., Vallee B.L., Davidson W.S., Joernvall H.;
"Avian alcohol dehydrogenase: the chicken liver enzyme. Primary structure, cDNA-cloning, and relationships to other alcohol dehydrogenases.";
Eur. J. Biochem. 194:593-602(1990).
[2]
 PROTEIN SEQUENCE OF 2-17 AND 360-376.
DOI=10.1016/0014-5793(90)81152-E; PubMed=2387402 [NCBI, ExPASy, EBI, Israel, Japan]
Egestad B., Estonius M., Danielsson O., Persson B., Cederlund E., Kaiser R., Holmquist B., Vallee B., Pares X., Jefferey J., Joernvall H.;
"Fast atom bombardment mass spectrometry and chemical analysis in determinations of acyl-blocked protein structures.";
FEBS Lett. 269:194-196(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X54612; CAA38433.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S13851; DECHA1.
UniGene Gga.4115
3D structure databases
HSSP P00327; 1HEU. [HSSP ENTRY / PDB]
SMR P23991; 2-376.
ModBase P23991.
Ontologies
GO
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS P23991.
Genome annotation databases
Ensembl ENSGALG00000012250; Gallus gallus. [Contig view]
Phylogenomic databases
HOVERGEN P23991; -.
Other
ProtoNet P23991.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cytoplasm; Direct protein sequencing; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   376  375     Alcohol dehydrogenase 1. PRO_0000160672
METAL   47    47        Zinc 1 (catalytic). 
METAL   68    68        Zinc 1 (catalytic). 
METAL   98    98        Zinc 2. 
METAL   101   101        Zinc 2. 
METAL   104   104        Zinc 2. 
METAL   112   112        Zinc 2. 
METAL   176   176        Zinc 1 (catalytic). 
MOD_RES   2     2        N-acetylserine. 
Sequence information
Length: 376 AA [This is the length of the unprocessed precursor] Molecular weight: 39808 Da [This is the MW of the unprocessed precursor] CRC64: CCD03989E53273DE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTVGKVIKC KAAVLWEANK PFSLEEVEVA PPKAHEVRIK IVATGICRSD DHVVTGALAM 

        70         80         90        100        110        120 
PFPIILGHEA AGVIESVGEK VTSLKPGDAV IPLFVPQCGE CRSCLSTKGN LCIKNDLSSS 

       130        140        150        160        170        180 
PTGLMADGTT RFTCKGKAIH HFVGTSTFTE YTVVHETAAA KIDSAAPLEK VCLIGCGFST 

       190        200        210        220        230        240 
GYGAVLQTAK VEAGSTCAVF GLGGVGLSVV MGCKAAGASR IIAVDINKDK FAKAKELGAT 

       250        260        270        280        290        300 
ECINPKDFKK PIHEVLTEMT GQGVDYSFEV IGRIETMTAA LASCHNNYGV SVIVGVPPAA 

       310        320        330        340        350        360 
QKISFDPMLI FSGRTWKGSV FGGWKSKDAV PKLVADYMKK KFVLDPLITH TLPFTKINEG 

       370 
FDLLRTGKSI RSVLVL
P23991 in FASTA format

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