[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=2279700 [NCBI, ExPASy, EBI, Israel, Japan] Gavin B.J., McMahon J.A., McMahon A.P.; "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."; Genes Dev. 4:2319-2332(1990).
[2]	INTERACTION WITH PORCN. PubMed=10866835 [NCBI, ExPASy, EBI, Israel, Japan] Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.; "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."; Eur. J. Biochem. 267:4300-4311(2000).

Comments

FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. May be an intracellular signaling molecule involved in segmentation of the forebrain. Is likely to signal over only few cell diameters (By similarity). Seems to be involved in kidney development.
SUBUNIT: Interacts with PORCN.
INTERACTION:
O35082:Kl; NbExp=1; IntAct=EBI-1570945, EBI-1570828;
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: In adults in lung and brain.
SIMILARITY: Belongs to the Wnt family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M89797; AAA40566.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

C36470; C36470.

NP_033549.1; -.

3D structure databases

ModBase

P22724.

Protein-protein interaction databases

IntAct

P22724; -.

Organism-specific databases

MGI

MGI:98957; Wnt4.

Gene expression databases

ArrayExpress

P22724; -.

CleanEx

MM_WNT4; -.

GermOnline

ENSMUSG00000036856; Mus musculus.

Ontologies

GO:0005102;	Molecular function: receptor binding (traceable author statement from MGI).
GO:0007267;	Biological process: cell-cell signaling (traceable author statement from MGI).
GO:0001838;	Biological process: embryonic epithelial tube formation (inferred from direct assay from MGI).
GO:0008585;	Biological process: female gonad development (inferred from mutant phenotype from MGI).
GO:0042445;	Biological process: hormone metabolic process (inferred from mutant phenotype from MGI).
GO:0008584;	Biological process: male gonad development (inferred from mutant phenotype from MGI).
GO:0045596;	Biological process: negative regulation of cell differentiation (inferred from mutant phenotype from MGI).
GO:0040037;	Biological process: negative regulation of fibroblast growth factor receptor signaling pathway (inferred from genetic interaction from MGI).
GO:0048599;	Biological process: oocyte development (inferred from mutant phenotype from MGI).
GO:0009887;	Biological process: organ morphogenesis (inferred from mutant phenotype from MGI).
GO:0051145;	Biological process: smooth muscle cell differentiation (inferred from direct assay from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR009142; Wnt4.
IPR005816; Wnt_grthfactor.
IPR005817; Wnt_SF.
Graphical view of domain structure.

PANTHER

PTHR12027; Wnt; 1.
PTHR12027:SF19; Wnt4; 1.

Pfam

PF00110; wnt; 1.
Pfam graphical view of domain structure.

PRINTS

PR01844; WNT4PROTEIN.
PR01349; WNTPROTEIN.

SMART

SM00097; WNT1; 1.
SMART graphical view of domain structure.

PS00246; WNT1; 1.

Genome annotation databases

Ensembl

ENSMUSG00000036856; Mus musculus. [Contig view]

GeneID

22417; -.

KEGG

mmu:22417; -.

Phylogenomic databases

HOGENOM

P22724; -.

HOVERGEN

P22724; -.

Other

NextBio

302837; -.

SOURCE

Wnt4; Mus musculus.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Developmental protein; Extracellular matrix; Glycoprotein; Secreted; Signal; Wnt signaling pathway.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 22`	`22`	`Potential.`
`CHAIN`	`23 351`	`329`	`Protein Wnt-4.`	`PRO_0000041422`
`CARBOHYD`	`88 88`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`297 297`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 351 AA [This is the length of the unprocessed precursor]

Molecular weight: 39050 Da [This is the MW of the unprocessed precursor]

CRC64: 7E1C5C739BE939D9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSPRSCLRSL RLLVFAVFSA AASNWLYLAK LSSVGSISEE ETCEKLKGLI QRQVQMCKRN 

        70         80         90        100        110        120 
LEVMDSVRRG AQLAIEECQY QFRNRRWNCS TLDSLPVFGK VVTQGTREAA FVYAISSAGV 

       130        140        150        160        170        180 
AFAVTRACSS GELEKCGCDR TVHGVSPQGF QWSGCSDNIA YGVAFSQSFV DVRERSKGAS 

       190        200        210        220        230        240 
SSRALMNLHN NEAGRKAILT HMRVECKCHG VSGSCEVKTC WRAVPPFRQV GHALKEKFDG 

       250        260        270        280        290        300 
ATEVEPRRVG SSRALVPRNA QFKPHTDEDL VYLEPSPDFC EQDIRSGVLG TRGRTCNKTS 

       310        320        330        340        350 
KAIDGCELLC CGRGFHTAQV ELAERCGCRF HWCCFVKCRQ CQRLVEMHTC R

P22724 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools