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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle;
PubMed=1986382 [NCBI, ExPASy, EBI, Israel, Japan]
Philipson L.H.,
Hice R.E.,
Schaefer K.,
Lamendola J.,
Bell G.I.,
Nelson D.J.,
Steiner D.F.;
"Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.";
Proc. Natl. Acad. Sci. U.S.A. 88:53-57(1991).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle;
DOI=10.1093/nar/18.23.7160; PubMed=2263489 [NCBI, ExPASy, EBI, Israel, Japan]
Philipson L.H.,
Schaefer K.,
Lamendola J.,
Bell G.I.,
Steiner D.F.;
"Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4.";
Nucleic Acids Res. 18:7160-7160(1990).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
PubMed=2001794 [NCBI, ExPASy, EBI, Israel, Japan]
Tamkun M.M.,
Knoth K.M.,
Walbridge J.A.,
Kroemer H.,
Roden D.M.,
Glover D.M.;
"Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle.";
FASEB J. 5:331-337(1991).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Ramaswami M.,
Gautam M.,
Kamb A.,
Rudy B.,
Tanouye M.A.,
Mathew M.K.;
"Human potassium channel genes: molecular cloning and functional expression.";
Mol. Cell. Neurosci. 1:214-223(1990).
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- FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
- SUBUNIT: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with OPRS1 (By similarity).
- INTERACTION:
P31016:Dlg4 (xeno); NbExp=1; IntAct=EBI-631235, EBI-375655;
- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
- DOMAIN: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
- DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
- SIMILARITY: Belongs to the potassium channel family. A (Shaker) subfamily.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 653 AA [This is the length of the unprocessed precursor] |
Molecular weight: 73288 Da [This is the MW of the unprocessed precursor] |
CRC64: 7A66781F827D6F27 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MEVAMVSAES SGCNSHMPYG YAAQARARER ERLAHSRRAA ARAVAAATAA VEGSGGSGGG
70 80 90 100 110 120
SHHHHQSRGA CTSHDPQSSR GSREEEATRS EKKKAHYRQS SFPHCSDLMP SGSEEKILRE
130 140 150 160 170 180
LSEEEEDEEE EEEEEEEGRF YYSEDDHGDE CSYTDLLPQD EGGGGYSSVR YSDCCERVVI
190 200 210 220 230 240
NVSGLRFETQ MKTLAQFPET LLGDPEKRTQ YFDPLRNEYF FDRNRPSFDA ILYYYQSGGR
250 260 270 280 290 300
LKRPVNVPFD IFTEEVKFYQ LGEEALLKFR EDEGFVREEE DRALPENEFK KQIWLLFEYP
310 320 330 340 350 360
ESSDPARGIA IVSVLVILIS IVIFCLETLP EFRDDRDLVM ALSAGGHGGL LNDTSAPHLE
370 380 390 400 410 420
NSGHTIFNDP FFIVETVCIV WFSFEFVVRC FACPSQALFF KNIMNIIDIV SILPYFITLG
430 440 450 460 470 480
TDLAQQQGGG NGQQQQAMSF AILRIIRLVR VFRIFKLSRH SKGLQILGHT LRASMRELGL
490 500 510 520 530 540
LIFFLFIGVI LFSSAVYFAE ADEPTTHFQS IPDAFWWAVV TMTTVGYGDM KPITVGGKIV
550 560 570 580 590 600
GVLCAIAGVL TIALPVPVIV SNFNYFYHRE TENEEQTQLT QNAVSCPYLP SNLLKKFRSS
610 620 630 640 650
TSSSLGDKSE YLEMEEGVKE SLCAKEEKCQ AKGDDSETDK NNCSNAKAVE TDV
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P22459 in FASTA format |
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