ID   ADH1_KLULA              Reviewed;         350 AA.
AC   P20369;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-NOV-2008, entry version 57.
DE   RecName: Full=Alcohol dehydrogenase 1;
DE            EC=1.1.1.1;
DE   AltName: Full=Alcohol dehydrogenase I;
GN   Name=ADH1; OrderedLocusNames=KLLA0F21010g;
OS   Kluyveromyces lactis (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=28985;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=90273773; PubMed=2190430; DOI=10.1002/yea.320060304;
RA   Saliola M., Shuster J.R., Falcone C.;
RT   "The alcohol dehydrogenase system in the yeast, Kluyveromyces
RT   lactis.";
RL   Yeast 6:193-204(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone +
CC       NADH.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CR382126; CAG98731.1; -; Genomic_DNA.
DR   PIR; S09475; S09475.
DR   RefSeq; XP_456023.1; -.
DR   HSSP; P39462; 1JVB.
DR   SMR; P20369; 4-350.
DR   GeneID; 2895056; -.
DR   KEGG; kla:KLLA0F21010g; -.
DR   HOGENOM; P20369; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004022; F:alcohol dehydrogenase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:InterPro.
DR   InterPro; IPR013154; AlcDHase_GroES-like.
DR   InterPro; IPR002085; AlcDHase_SF_Zn.
DR   InterPro; IPR013149; AlcDHase_Zn-bd.
DR   InterPro; IPR002328; AlcDHase_Zn_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Metal-binding; NAD; Oxidoreductase;
KW   Zinc.
FT   CHAIN         1    350       Alcohol dehydrogenase 1.
FT                                /FTId=PRO_0000160722.
FT   METAL        46     46       Zinc 1; catalytic.
FT   METAL        69     69       Zinc 1; catalytic.
FT   METAL       100    100       Zinc 2.
FT   METAL       103    103       Zinc 2.
FT   METAL       106    106       Zinc 2.
FT   METAL       114    114       Zinc 2.
FT   METAL       156    156       Zinc 1; catalytic.
SQ   SEQUENCE   350 AA;  37261 MW;  3D71BE2D5CC86119 CRC64;
     MAASIPETQK GVIFYENGGE LQYKDIPVPK PKANELLINV KYSGVCHTDL HAWKGDWPLP
     TKLPLVGGHE GAGVVVAMGE NVKGWKIGDF AGIKWLNGSC MSCEYCELSN ESNCPEADLS
     GYTHDGSFQQ YATADAVQAA KIPVGTDLAE VAPVLCAGVT VYKALKSANL KAGDWVAISG
     AAGGLGSLAV QYAKAMGYRV LGIDAGEEKA KLFKDLGGEY FIDFTKSKNI PEEVIEATKG
     GAHGVINVSV SEFAIEQSTN YVRSNGTVVL VGLPRDAKCK SDVFNQVVKS ISIVGSYVGN
     RADTREAIDF FSRGLVKAPI HVVGLSELPS IYEKMEKGAI VGRYVVDTSK
//