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UniProtKB/Swiss-Prot entry P20369


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_KLULA
Primary accession number P20369
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1991
Sequence was last modified on February 1, 1991 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 54)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonyms EC 1.1.1.1
Alcohol dehydrogenase I
Gene name
Name: ADH1
OrderedLocusNames: KLLA0F21010g
From
Kluyveromyces lactis (Yeast) (Candida sphaerica) [TaxID: 28985] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2190430 [NCBI, ExPASy, EBI, Israel, Japan]
Saliola M., Shuster J.R., Falcone C.;
"The alcohol dehydrogenase system in the yeast, Kluyveromyces lactis.";
Yeast 6:193-204(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR382126; CAG98731.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S09475; S09475.
RefSeq XP_456023.1; -.
3D structure databases
HSSP P39462; 1JVB. [HSSP ENTRY / PDB]
SMR P20369; 4-350.
ModBase P20369.
Ontologies
GO
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS P20369.
Genome annotation databases
GeneID 2895056; -.
KEGG kla:KLLA0F21010g; -.
Phylogenomic databases
HOGENOM P20369; -.
Other
ProtoNet P20369.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   350  350     Alcohol dehydrogenase 1. PRO_0000160722
METAL   46    46        Zinc 1 (catalytic). 
METAL   69    69        Zinc 1 (catalytic). 
METAL   100   100        Zinc 2. 
METAL   103   103        Zinc 2. 
METAL   106   106        Zinc 2. 
METAL   114   114        Zinc 2. 
METAL   156   156        Zinc 1 (catalytic). 
Sequence information
Length: 350 AA [This is the length of the unprocessed precursor] Molecular weight: 37261 Da [This is the MW of the unprocessed precursor] CRC64: 3D71BE2D5CC86119 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAASIPETQK GVIFYENGGE LQYKDIPVPK PKANELLINV KYSGVCHTDL HAWKGDWPLP 

        70         80         90        100        110        120 
TKLPLVGGHE GAGVVVAMGE NVKGWKIGDF AGIKWLNGSC MSCEYCELSN ESNCPEADLS 

       130        140        150        160        170        180 
GYTHDGSFQQ YATADAVQAA KIPVGTDLAE VAPVLCAGVT VYKALKSANL KAGDWVAISG 

       190        200        210        220        230        240 
AAGGLGSLAV QYAKAMGYRV LGIDAGEEKA KLFKDLGGEY FIDFTKSKNI PEEVIEATKG 

       250        260        270        280        290        300 
GAHGVINVSV SEFAIEQSTN YVRSNGTVVL VGLPRDAKCK SDVFNQVVKS ISIVGSYVGN 

       310        320        330        340        350 
RADTREAIDF FSRGLVKAPI HVVGLSELPS IYEKMEKGAI VGRYVVDTSK 

P20369 in FASTA format

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