[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=2254258 [NCBI, ExPASy, EBI, Israel, Japan] Nordlund I., Powlowski J., Shingler V.; "Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600."; J. Bacteriol. 172:6826-6833(1990).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=BH; Takeo M., Maeda Y., Okada H., Miyama K., Mori K., Ike M., Fujita M.; Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catabolizes phenol, and some of its methylated derivatives. P3 is required for growth on phenol, and for in vitro phenol hydroxylase activity.
CATALYTIC ACTIVITY: Phenol + NADPH + O₂ = catechol + NADP⁺ + H₂O.
COFACTOR: FAD.
COFACTOR: Fe(2+).
PATHWAY: Aromatic compound metabolism; phenol degradation .
SUBUNIT: The multicomponent enzyme phenol hydroxylase is formed by P0, P1, P2, P3, P4 and P5 polypeptides.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M60276; AAA25942.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D28864; BAA06017.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

P19732; 7-500.

ModBase

P19732.

Enzyme and pathway databases

BioCyc

MetaCyc:MON-12797; -.

Family and domain databases

InterPro

IPR003430; Phenol_Hydrox.
IPR012348; Ribncl_red_rel.
IPR007029; YHS.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.620.20; Ribncl_red_rel; 1.

Pfam

PF02332; Phenol_Hydrox; 1.
PF04945; YHS; 1.
Pfam graphical view of domain structure.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; FAD; Flavoprotein; Iron; Monooxygenase; NADP; Oxidoreductase; Plasmid.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 517`	`517`		`Phenol hydroxylase P3 protein.`	`PRO_0000079945`

Sequence information

Length: 517 AA [This is the length of the unprocessed precursor]

Molecular weight: 60523 Da [This is the MW of the unprocessed precursor]

CRC64: 4EFD4EB40ED73F9C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MATHNKKRLN LKDKYRYLTR DLAWETTYQK KEDVFPLEHF EGIKITDWDK WEDPFRLTMD 

        70         80         90        100        110        120 
TYWKYQAEKE KKLYAIFDAF AQNNGHQNIS DARYVNALKL FLTAVSPLEY QAFQGFSRVG 

       130        140        150        160        170        180 
RQFSGAGARV ACQMQAIDEL RHVQTQVHAM SHYNKHFDGL HDFAHMYDRV WYLSVPKSYM 

       190        200        210        220        230        240 
DDARTAGPFE FLTAVSFSFE YVLTNLLFVP FMSGAAYNGD MATVTFGFSA QSDEARHMTL 

       250        260        270        280        290        300 
GLEVIKFMLE QHEDNVPIIQ RWIDKWFWRG YRLLTLIGMM MDYMLPNKVM SWSEAWGVYF 

       310        320        330        340        350        360 
EQAGGALFKD LERYGIRPPK YVEQTTIGKE HITHQVWGAL YQYSKATSFH TWIPGDEELN 

       370        380        390        400        410        420 
WLSEKYPDTF DKYYRPRFEF WREQQAKGER FYNDTLPHLC QVCQLPVIFT EPDDPTKLSL 

       430        440        450        460        470        480 
RSLVHEGERY QFCSDGCCDI FKNEPVKYIQ AWLPVHQIYQ GNCEGGDVET VVQKYYHIKS 

       490        500        510 
GVDNLEYLGS PEHQRWLALK GQTPPTAAPA DKSLGAA

P19732 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools