ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P17336


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name CATA_DROME
Primary accession number P17336
Secondary accession number Q9VVT1
Integrated into Swiss-Prot on August 1, 1990
Sequence was last modified on October 1, 1996 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 80)
Name and origin of the protein
Protein name Catalase
Synonym EC 1.11.1.6
Gene name
Name: Cat
ORFNames: CG6871
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/abbi.1996.0250; PubMed=8660653 [NCBI, ExPASy, EBI, Israel, Japan]
Orr W.C., Orr E.C., Legan S.K., Sohal R.S.;
"Molecular analysis of the Drosophila catalase gene.";
Arch. Biochem. Biophys. 330:251-258(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/18.12.3663; PubMed=2362827 [NCBI, ExPASy, EBI, Israel, Japan]
Orr E.C., Bewley G.C., Orr W.C.;
"cDNA and deduced amino acid sequence of Drosophila catalase.";
Nucleic Acids Res. 18:3663-3663(1990).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley;
TISSUE=Embryo;
PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan]
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[6]
PROTEIN SEQUENCE OF 76-92.
STRAIN=Vallecas;
TISSUE=Wing imaginal disk;
DOI=10.1006/excr.1993.1141; PubMed=8500545 [NCBI, ExPASy, EBI, Israel, Japan]
Santaren J.F., van Damme J., Puype M., Vandekerckhove J., Garcia-Bellido A.;
"Identification of Drosophila wing imaginal disc proteins by two-dimensional gel analysis and microsequencing.";
Exp. Cell Res. 206:220-226(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U00145; AAC13738.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X52286; CAA36529.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014296; AAF49228.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY084154; AAL89892.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S12725; CSFF.
RefSeq NP_536731.1; -.
UniGene Dm.6950
3D structure databases
HSSP P04040; 1F4J. [HSSP ENTRY / PDB]
ModBase P17336.
Protein-protein interaction databases
DIP DIP:18768N; -.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-017262-MON; -.
Organism-specific databases
FlyBase FBgn0000261; Cat.
Gene expression databases
ArrayExpress P17336; -.
GermOnline CG6871; Drosophila melanogaster.
Ontologies
GO
GO:0004096; Molecular function: catalase activity (inferred from direct assay from FlyBase).
GO:0008340; Biological process: determination of adult life span (traceable author statement from FlyBase).
GO:0042542; Biological process: response to hydrogen peroxide (inferred from mutant phenotype from FlyBase).
QuickGo view.
Family and domain databases
InterPro IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.
Gene3D G3DSA:2.40.180.10; Catalase_N; 1.
PANTHER PTHR11465; Catalase; 1.
Pfam PF00199; Catalase; 1.
Pfam graphical view of domain structure.
PRINTS PR00067; CATALASE.
ProDom PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.
BLOCKS P17336.
Genome annotation databases
Ensembl CG6871; Drosophila melanogaster. [Contig view]
GeneID 40048; -.
KEGG dme:Dmel_CG6871; -.
NMPDR fig|7227.3.peg.10459; -.
Phylogenomic databases
HOGENOM P17336; -.
Other
ProtoNet P17336.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase; Peroxisome.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   506  506     Catalase. PRO_0000084912
MOTIF   504   506  3     Microbody targeting signal (Potential). 
ACT_SITE   73    73        By similarity. 
ACT_SITE   146   146        By similarity. 
METAL   356   356        Iron (heme axial ligand) (By similarity). 
CONFLICT   5     5        D -> Y (in Ref. 1). 
CONFLICT   12    12        I -> N (in Ref. 1). 
Sequence information
Length: 506 AA [This is the length of the unprocessed precursor] Molecular weight: 57150 Da [This is the MW of the unprocessed precursor] CRC64: 396377DC5F784ECE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGRDAASNQ LIDYKNSQTV SPGAITTGNG APIGIKDASQ TVGPRGPILL QDVNFLDEMS 

        70         80         90        100        110        120 
HFDRERIPER VVHAKGAGAF GYFEVTHDIT QYCAAKIFDK VKKRTPLAVR FSTVGGESGS 

       130        140        150        160        170        180 
ADTARDPRGF AVKFYTEDGV WDLVGNNTPV FFIRDPILFP SFIHTQKRNP QTHLKDPDMF 

       190        200        210        220        230        240 
WDFLTLRPES AHQVCILFSD RGTPDGYCHM NGYGSHTFKL INAKGEPIYA KFHFKTDQGI 

       250        260        270        280        290        300 
KNLDVKTADQ LASTDPDYSI RDLYNRIKTC KFPSWTMYIQ VMTYEQAKKF KYNPFDVTKV 

       310        320        330        340        350        360 
WSQKEYPLIP VGKMVLDRNP KNYFAEVEQI AFSPAHLVPG VEPSPDKMLH GRLFSYSDTH 

       370        380        390        400        410        420 
RHRLGPNYLQ IPVNCPYKVK IENFQRDGAM NVTDNQDGAP NYFPNSFNGP QECPRARALS 

       430        440        450        460        470        480 
SCCPVTGDVY RYSSGDTEDN FGQVTDFWVH VLDKCAKKRL VQNIAGHLSN ASQFLQERAV 

       490        500 
KNFTQVHADF GRMLTEELNL AKSSKF 

P17336 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by kr flag YPRC Korea Mirror sites: Australia  Brazil  Canada  China  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!