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UniProtKB/Swiss-Prot entry P17290

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TPH1_RABIT
Primary accession number P17290
Secondary accession number Q29523
Integrated into Swiss-Prot on August 1, 1990
Sequence was last modified on November 1, 1997 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 66)
Name and origin of the protein
Protein name Tryptophan 5-hydroxylase 1
Synonyms EC 1.14.16.4
Tryptophan 5-monooxygenase 1
Gene name
Name: TPH1
Synonyms: TPH
From
Oryctolagus cuniculus (Rabbit) [TaxID: 9986] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3475690 [NCBI, ExPASy, EBI, Israel, Japan]
Grenett H.E., Ledley F.D., Reed L.L., Woo S.L.C.;
"Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases.";
Proc. Natl. Acad. Sci. U.S.A. 84:5530-5534(1987).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1006/abbi.1994.1523; PubMed=7986090 [NCBI, ExPASy, EBI, Israel, Japan]
Tipper J.P., Citron B.A., Ribeiro P., Kaufman S.;
"Cloning and expression of rabbit and human brain tryptophan hydroxylase cDNA in Escherichia coli.";
Arch. Biochem. Biophys. 315:445-453(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M17250; AAA31487.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L29305; AAA67051.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S51199; S51199.
RefSeq NP_001075741.1; -.
NP_001093425.1; -.
UniGene Ocu.2025
3D structure databases
HSSP P17752; 1MLW. [HSSP ENTRY / PDB]
SMR P17290; 104-393.
ModBase P17290.
Family and domain databases
InterPro IPR001273; Aaa_hydroxylase.
IPR002912; ACT_bd.
IPR005963; Tyr_5_mOase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
PANTHER PTHR11473; Aaa_hydroxylase; 1.
Pfam PF01842; ACT; 1.
PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.
PRINTS PR00372; FYWHYDRXLASE.
ProDom PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01270; Trp_5_monoox; 1.
PROSITE PS00367; BIOPTERIN_HYDROXYL; 1.
BLOCKS P17290.
Genome annotation databases
GeneID 100009100; -.
100101558; -.
Phylogenomic databases
HOVERGEN P17290; -.
Other
ProtoNet P17290.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phosphoprotein; Serotonin biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   444  444     Tryptophan 5-hydroxylase 1. PRO_0000205570
DOMAIN   18    92  75     ACT. 
METAL   272   272        Iron (By similarity). 
METAL   277   277        Iron (By similarity). 
METAL   317   317        Iron (By similarity). 
MOD_RES   58    58        Phosphoserine; by PKA (Potential). 
CONFLICT   102   102        M -> L (in Ref. 1; AAA31487). 
CONFLICT   151   151        L -> S (in Ref. 2; AAA67051). 
CONFLICT   202   203        KY -> ND (in Ref. 1; AAA31487). 
CONFLICT   207   207        R -> Q (in Ref. 2; AAA67051). 
CONFLICT   390   390        T -> K (in Ref. 1; AAA31487). 
Sequence information
Length: 444 AA [This is the length of the unprocessed precursor] Molecular weight: 51118 Da [This is the MW of the unprocessed precursor] CRC64: BF182451B28ECD80 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIEDNKENKD HSLERGRATL IFSLKNEVGG LIKALKIFQE KHVNLLHIES RKSKRRNSEF 

        70         80         90        100        110        120 
EIFVDCDTNR EQLNDIFHLL KSHTNVLSVT PPDNFTMKEE GMESVPWFPK KISDLDHCAN 

       130        140        150        160        170        180 
RVLMYGSELD ADHPGFKDNV YRKRRKYFAD LAMSYKYGDP IPKVEFTEEE IKTWGTVFRE 

       190        200        210        220        230        240 
LNKLYPTHAC REYLKNLPLL SKYCGYREDN IPQLEDISNF LKERTGFSIR PVAGYLSPRD 

       250        260        270        280        290        300 
FLSGLAFRVF HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA 

       310        320        330        340        350        360 
SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHVLSGHAK VKPFDPKITY 

       370        380        390        400        410        420 
KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK YNPYTRSIQI LKDAKSITNA 

       430        440 
MNELRHDLDV VSDALGKVSR QLSV
P17290 in FASTA format

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