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UniProtKB/Swiss-Prot entry P14137


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP11A_RAT
Primary accession number P14137
Secondary accession numbers Q5FWY8 Q6LDR9
Integrated into Swiss-Prot on January 1, 1990
Sequence was last modified on January 1, 1990 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 70)
Name and origin of the protein
Protein name Cytochrome P450 11A1, mitochondrial [Precursor]
Synonyms EC 1.14.15.6
CYPXIA1
Cholesterol side-chain cleavage enzyme
P450(scc)
Cholesterol desmolase
Gene name
Name: Cyp11a1
Synonyms: Cyp11a, Cyp11a-1
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2480959 [NCBI, ExPASy, EBI, Israel, Japan]
Oonk R.B., Krasnow J.S., Beattie W.G., Richards J.S.;
"Cyclic AMP-dependent and -independent regulation of cholesterol side chain cleavage cytochrome P-450 (P-450scc) in rat ovarian granulosa cells and corpora lutea. cDNA and deduced amino acid sequence of rat P-450scc.";
J. Biol. Chem. 264:21934-21942(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2176216 [NCBI, ExPASy, EBI, Israel, Japan]
Oonk R.B., Parker K.L., Gibson J.L., Richards J.S.;
"Rat cholesterol side-chain cleavage cytochrome P-450 (P-450scc) gene. Structure and regulation by cAMP in vitro.";
J. Biol. Chem. 265:22392-22401(1990).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 344-526, AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley;
TISSUE=Ovary;
DOI=10.1016/0378-1119(87)90170-3; PubMed=3123325 [NCBI, ExPASy, EBI, Israel, Japan]
McMasters K.M., Dickson L.A., Shamy R.V., Robischon K., Macdonald G.J., Moyle W.R.;
"Rat cholesterol side-chain cleavage enzyme (P-450scc): use of a cDNA probe to study the hormonal regulation of P-450scc mRNA levels in ovarian granulosa cells.";
Gene 57:1-9(1987).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J05156; AAA40989.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63133; AAA40958.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63125; AAA40958.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63126; AAA40958.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63127; AAA40958.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63128; AAA40958.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63129; AAA40958.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63130; AAA40958.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63131; AAA40958.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63132; AAA40958.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC089100; AAH89100.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M22615; AAA62267.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A34164; A34164.
RefSeq NP_058982.1; -.
UniGene Rn.1401
3D structure databases
HSSP P00189; 1SCC. [HSSP ENTRY / PDB]
ModBase P14137.
Organism-specific databases
RGD 69325; Cyp11a1.
Gene expression databases
ArrayExpress P14137; -.
GermOnline ENSRNOG00000008074; Rattus norvegicus.
Ontologies
GO
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS P14137.
Genome annotation databases
Ensembl ENSRNOG00000008074; Rattus norvegicus. [Contig view]
GeneID 29680; -.
KEGG rno:29680; -.
Phylogenomic databases
HOVERGEN P14137; -.
Other
ProtoNet P14137.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol metabolism; Heme; Iron; Lipid metabolism; Membrane; Metal-binding; Mitochondrion; Monooxygenase; Oxidoreductase; Steroid metabolism; Steroidogenesis; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    36  36     Mitochondrion. 
CHAIN   37   526  490     Cytochrome P450 11A1, mitochondrial. PRO_0000003590
METAL   459   459        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 526 AA [This is the length of the unprocessed precursor] Molecular weight: 60586 Da [This is the MW of the unprocessed precursor] CRC64: B2930E40018DC1EE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLAKGLCLRS VLVKSCQPFL SPVWQGPGLA TGNGAGISST NSPRSFNEIP SPGDNGWINL 

        70         80         90        100        110        120 
YHFLRENGTH RIHYHHMQNF QKYGPIYREK LGNMESVYIL DPKDAATLFS CEGPNPERYL 

       130        140        150        160        170        180 
VPPWVAYHQY YQRPIGVLFK SSDAWRKDRI VLNQEVMAPD SIKNFVPLLE GVAQDFIKVL 

       190        200        210        220        230        240 
HRRIKQQNSG KFSGDISDDL FRFAFESITS VVFGERLGML EEIVDPESQR FIDAVYQMFH 

       250        260        270        280        290        300 
TSVPMLNMPP DLFRLFRTKT WKDHAAAWDV IFSKADEYTQ NFYWDLRQKR DFSKYPGVLY 

       310        320        330        340        350        360 
SLLGGNKLPF KNIQANITEM LAGGVDTTSM TLQWNLYEMA HNLKVQEMLR AEVLAARRQA 

       370        380        390        400        410        420 
QGDMAKMVQL VPLLKASIKE TLRLHPISVT LQRYIVNDLV LRNYKIPAKT LVQVASYAMG 

       430        440        450        460        470        480 
RESSFFPNPN KFDPTRWLEK SQNTTHFRYL GFGWGVRQCL GRRIAELEMT IFLINVLENF 

       490        500        510        520 
RIEVQSIRDV GTKFNLILMP EKPIFFNFQP LKQDLGSTMP RKGDTV 

P14137 in FASTA format

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View entry in raw text format (no links)
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