[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1016/0014-5793(88)80548-9; PubMed=2846351 [NCBI, ExPASy, EBI, Israel, Japan]
Peltoketo H.,
Isomaa V.,
Maeentausta O.,
Vihko R.;
"Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.";
FEBS Lett. 239:73-77(1988).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=2779584 [NCBI, ExPASy, EBI, Israel, Japan]
Luu-The V.,
Labrie C.,
Zhao H.F.,
Couet J.,
Lachance Y.,
Simard J.,
Leblanc G.,
Labrie F.;
"Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta.";
Mol. Endocrinol. 3:1301-1309(1989).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2330005 [NCBI, ExPASy, EBI, Israel, Japan]
Luu-The V.,
Labrie C.,
Simard J.,
Lachance Y.,
Zhao H.F.,
Couet J.,
Leblanc G.,
Labrie F.;
"Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes.";
Mol. Endocrinol. 4:268-275(1990).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2197970 [NCBI, ExPASy, EBI, Israel, Japan]
Luu-The V.,
Labrie C.,
Zhao H.F.,
Couet J.,
Lachance Y.,
Simard J.,
Cote J.,
Leblanc G.,
Lagace L.,
Berube D.,
Gagne R.,
Labrie F.;
"Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase.";
Ann. N. Y. Acad. Sci. 595:40-52(1990).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1327779 [NCBI, ExPASy, EBI, Israel, Japan]
Peltoketo H.E.,
Isomma V.,
Vihko R.;
"Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements.";
Eur. J. Biochem. 209:459-466(1992).
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[6]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Shen Y.,
Gibbs R.A.;
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
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[7]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[8]
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PROTEIN SEQUENCE OF 2-6.
DOI=10.1021/bi00764a023; PubMed=5045524 [NCBI, ExPASy, EBI, Israel, Japan]
Burns D.J.W.,
Engel L.L.,
Bethune J.L.;
"Amino acid composition and subunit structure. Human placental 17 - estradiol dehydrogenase.";
Biochemistry 11:2699-2703(1972).
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[9]
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PROTEIN SEQUENCE OF 52-68.
DOI=10.1016/0014-5793(73)80554-X; PubMed=4719204 [NCBI, ExPASy, EBI, Israel, Japan]
Nicholas J.C.,
Harris J.I.;
"Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine.";
FEBS Lett. 29:173-176(1973).
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[10]
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PROTEIN SEQUENCE OF 205-224.
DOI=10.1021/bi00351a019; PubMed=3456799 [NCBI, ExPASy, EBI, Israel, Japan]
Murdock G.L.,
Chin C.-C.,
Warren J.C.;
"Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region.";
Biochemistry 25:641-646(1986).
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[11]
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PROTEIN SEQUENCE OF 220-224.
PubMed=6578212 [NCBI, ExPASy, EBI, Israel, Japan]
Murdock G.L.,
Chin C.C.,
Offord R.E.,
Bradshaw R.A.,
Warren J.C.;
"Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione.";
J. Biol. Chem. 258:11460-11464(1983).
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[12]
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SIMILARITY TO SHORT CHAIN DEHYDROGENASES.
PubMed=2547159 [NCBI, ExPASy, EBI, Israel, Japan]
Baker M.E.;
"Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti.";
Mol. Endocrinol. 3:881-884(1989).
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[13]
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X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
DOI=10.1016/S0969-2126(01)00183-6; PubMed=7663947 [NCBI, ExPASy, EBI, Israel, Japan]
Ghosh D.,
Pletnev V.Z.,
Zhu D.W.,
Wawrzak Z.,
Duax W.L.,
Pangborn W.,
Labrie F.,
Lin S.-X.;
"Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20-A resolution.";
Structure 3:503-513(1995).
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[14]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
DOI=10.1038/nsb0896-665; PubMed=8756321 [NCBI, ExPASy, EBI, Israel, Japan]
Azzi A.,
Rehse P.H.,
Zhu D.W.,
Campbell R.L.,
Labrie F.,
Lin S.X.;
"Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol.";
Nat. Struct. Biol. 3:665-668(1996).
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[15]
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X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH SUBSTRATE AND NADP.
DOI=10.1016/S0969-2126(96)00098-6; PubMed=8805577 [NCBI, ExPASy, EBI, Israel, Japan]
Breton R.,
Housset D.,
Mazza C.,
Fontecilla-Camps J.-C.;
"The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.";
Structure 4:905-915(1996).
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[16]
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X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
DOI=10.1074/jbc.273.14.8145; PubMed=9525918 [NCBI, ExPASy, EBI, Israel, Japan]
Mazza C.,
Breton R.,
Housset D.,
Fontecilla-Camps J.-C.;
"Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase.";
J. Biol. Chem. 273:8145-8152(1998).
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[17]
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X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
DOI=10.1073/pnas.96.3.840; PubMed=9927655 [NCBI, ExPASy, EBI, Israel, Japan]
Sawicki M.W.,
Erman M.,
Puranen T.,
Vihko P.,
Ghosh D.;
"Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.";
Proc. Natl. Acad. Sci. U.S.A. 96:840-845(1999).
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[18]
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X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 39-328, AND MUTAGENESIS OF LEU-150.
DOI=10.1074/jbc.275.2.1105; PubMed=10625652 [NCBI, ExPASy, EBI, Israel, Japan]
Han Q.,
Campbell R.L.,
Gangloff A.,
Huang Y.-W.,
Lin S.-X.;
"Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain.";
J. Biol. Chem. 275:1105-1111(2000).
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[19]
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X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
DOI=10.1096/fj.02-0026fje; PubMed=12223444 [NCBI, ExPASy, EBI, Israel, Japan]
Qiu W.,
Campbell R.L.,
Gangloff A.,
Dupuis P.,
Boivin R.P.,
Tremblay M.R.,
Poirier D.,
Lin S.X.;
"A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity.";
FASEB J. 16:1829-1831(2002).
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[20]
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X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).
DOI=10.1096/fj.02-0397fje; PubMed=12490543 [NCBI, ExPASy, EBI, Israel, Japan]
Gangloff A.,
Shi R.,
Nahoum V.,
Lin S.X.;
"Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase.";
FASEB J. 17:274-276(2003).
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[21]
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X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS).
DOI=10.1074/jbc.M313156200; PubMed=14966133 [NCBI, ExPASy, EBI, Israel, Japan]
Shi R.,
Lin S.X.;
"Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation.";
J. Biol. Chem. 279:16778-16785(2004).
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[22]
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VARIANTS VAL-238 AND GLY-313.
DOI=10.1093/hmg/2.4.479; PubMed=8389226 [NCBI, ExPASy, EBI, Israel, Japan]
Normand T.,
Narod S.,
Labrie F.,
Simard J.;
"Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21.";
Hum. Mol. Genet. 2:479-483(1993).
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