[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Corpus luteum; DOI=10.1093/nar/17.19.7990; PubMed=2798140 [NCBI, ExPASy, EBI, Israel, Japan] Jones D.S.C., Flint A.P.F.; "Nucleotide sequence of a full length cDNA clone encoding the oxytocin-neurophysin I precursor isolated from the ovine corpus luteum."; Nucleic Acids Res. 17:7990-7990(1989).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. TISSUE=Ovary; PubMed=2095591 [NCBI, ExPASy, EBI, Israel, Japan] Ivell R., Hunt N., Abend N., Brackman B., Nollmeyer D., Lamsa J.C., McCracken J.A.; "Structure and ovarian expression of the oxytocin gene in sheep."; Reprod. Fertil. Dev. 2:703-711(1990).
[3]	PROTEIN SEQUENCE OF 20-28. Acher R., Chauvet J., Lenci M.T.; "Purification and structure of sheep oxytocin and vasopressin."; C.R. Hebd. Seances Acad. Sci., D, Sci. Nat. 248:1435-1438(1959).

Comments

FUNCTION: Neurophysin 1 specifically binds oxytocin.
FUNCTION: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
SIMILARITY: Belongs to the vasopressin/oxytocin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X16052; CAA34184.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X16052; CAA34185.1; ALT_SEQ; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X16052; CAA34186.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X55131; CAA38924.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S06086; NFSH1.

UniGene

Oar.444

3D structure databases

SMR

P13389; 32-123.

ModBase

P13389.

Family and domain databases

InterPro

IPR000981; Neurhyp_horm.
IPR016321; Nonapeptide_hormone_prcur.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.9.10; Neurhyp_horm; 1.

Pfam

PF00220; Hormone_4; 1.
PF00184; Hormone_5; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001815; Nonapeptide_hormone_precursor; 1.

PRINTS

PR00831; NEUROPHYSIN.

ProDom

PD001676; Neurhyp_horm; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00003; NH; 1.
SMART graphical view of domain structure.

PROSITE

PS00264; NEUROHYPOPHYS_HORM; 1.

BLOCKS

P13389.

Phylogenomic databases

HOVERGEN

P13389; -.

Other

P13389; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`
`PEPTIDE`	`20 28`	`9`	`Oxytocin.`	`PRO_0000020505`
`CHAIN`	`32 125`	`94`	`Neurophysin 1.`	`PRO_0000020506`
`MOD_RES`	`28 28`		`Glycine amide.`
`DISULFID`	`20 25`
`DISULFID`	`41 85`		`By similarity.`
`DISULFID`	`44 58`		`By similarity.`
`DISULFID`	`52 75`		`By similarity.`
`DISULFID`	`59 65`		`By similarity.`
`DISULFID`	`92 104`		`By similarity.`
`DISULFID`	`98 116`		`By similarity.`
`DISULFID`	`105 110`		`By similarity.`
`CONFLICT`	`48 48`		`G -> A (in Ref. 1; CAA34184/CAA34186).`
`CONFLICT`	`110 110`		`C -> S (in Ref. 1; CAA34184/CAA34186).`

Sequence information

Length: 125 AA [This is the length of the unprocessed precursor]

Molecular weight: 12635 Da [This is the MW of the unprocessed precursor]

CRC64: 3B4C05141422E432 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAGSSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDVRT CLPCGPGGKG RCFGPSICCG 

        70         80         90        100        110        120 
DELGCFVGTA EALRCREENY LPSPCQSGQK PCGSGGRCAA AGICCSPDGC HADPACDPEA 


AFSQH

P13389 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools