[1]	NUCLEOTIDE SEQUENCE. STRAIN=cv. Wisconsin 64A; PubMed=16668346 [NCBI, ExPASy, EBI, Israel, Japan] Guan L., Ruzsa S., Skadsen R.W., Scandalios J.G.; "Comparison of the cat2 complementary DNA sequences of a normal catalase activity line (W64A) and a high catalase activity line (R6-67) of maize."; Plant Physiol. 96:1379-1381(1991).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=cv. Wisconsin 64A; TISSUE=Leaf; DOI=10.1007/BF00020803; PubMed=8639750 [NCBI, ExPASy, EBI, Israel, Japan] Guan L., Polidoros A.N., Scandalios J.G.; "Isolation, characterization and expression of the maize Cat2 catalase gene."; Plant Mol. Biol. 30:913-924(1996).
[3]	PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=cv. R6-67; PubMed=2821546 [NCBI, ExPASy, EBI, Israel, Japan] Bethards L.A., Skadsen R.W., Scandalios J.G.; "Isolation and characterization of a cDNA clone for the Cat2 gene in maize and its homology with other catalases."; Proc. Natl. Acad. Sci. U.S.A. 84:6830-6834(1987).
[4]	SEQUENCE REVISION TO C-TERMINUS. PubMed=2395887 [NCBI, ExPASy, EBI, Israel, Japan] Bethards L.A., Skadsen R.W., Scandalios J.G.; "Isolation and characterization of a cDNA clone for the Cat2 gene in maize and its homology with other catalases."; Proc. Natl. Acad. Sci. U.S.A. 87:6927-6927(1990).

Comments

FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
COFACTOR: Heme group.
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Peroxisome. Cytoplasm.
SIMILARITY: Belongs to the catalase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X54819; CAA38588.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Z54358; -; NOT_ANNOTATED_CDS; Genomic_DNA.	[EMBL / GenBank / DDBJ]
J02976; AAA33440.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S71455; S71455.

NP_001105310.1; -.

3D structure databases

HSSP

P46206; 1M7S. [HSSP ENTRY / PDB]

ModBase

P12365.

Organism-specific databases

Gramene

P12365; -.

MaizeGDB

13855; -.

Family and domain databases

InterPro

IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.180.10; Catalase_N; 1.

PANTHER

PTHR11465; Catalase; 1.

Pfam

PF00199; Catalase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00067; CATALASE.

ProDom

PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.

BLOCKS

P12365.

Genome annotation databases

GeneID

542230; -.

Other

ProtoNet

P12365.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase; Peroxisome; Polymorphism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 491`	`491`	`Catalase isozyme 2.`	`PRO_0000084947`
`ACT_SITE`	`64 64`		`By similarity.`
`ACT_SITE`	`137 137`		`By similarity.`
`METAL`	`347 347`		`Iron (heme axial ligand) (By similarity).`
`VARIANT`	`296 296`	`1`	`T -> R.`
`CONFLICT`	`14 14`		`A -> P (in Ref. 3; AAA33440).`
`CONFLICT`	`124 124`		`K -> N (in Ref. 3; AAA33440).`
`CONFLICT`	`241 242`		`RC -> AVG (in Ref. 2).`
`CONFLICT`	`296 296`		`T -> A (in Ref. 2).`

Sequence information

Length: 491 AA [This is the length of the unprocessed precursor]

Molecular weight: 56466 Da [This is the MW of the unprocessed precursor]

CRC64: 6B686B6A94EA8598 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDPYKHRPSS AFNAPYWTTN SGAPVWNNDS SLTVGARGPI LLEDYHCEKL ANFDRERIPE 

        70         80         90        100        110        120 
RVVHARGASA KGFFEVTHDI THLTCADFLR APGVQTPVIV RFSTVIHERG SPETLRDPRG 

       130        140        150        160        170        180 
FAVKFYTREG NWDLVGNNFP VFFIRDGIKF PDMVHALKPN PRTHIQDNWR ILDFFSHHPE 

       190        200        210        220        230        240 
SLHMFSFLFD DVGIPADYRH MDGSGVHTYT LVSRAGTVTY VKFHWRPTCG VRSLMDDEAV 

       250        260        270        280        290        300 
RCGANHSHAT KDLTDAIAAG NFPEWTLYIQ TMDPEMEDRL DDLDPLDVTK TWPEDTFPLQ 

       310        320        330        340        350        360 
PVGRLVLNRN IDNFFAENEQ LAFCPGLIVP GIYYSDDKLL QTRIFSYSDT QRHRLGPNYL 

       370        380        390        400        410        420 
LLPANAPKCA HHNNHYDGSM NFMHRHEEVD YFPSRYDAVR NAPRYPIPTA HIAGRREKTV 

       430        440        450        460        470        480 
ISKENNFKQP GERYRAMDPA RQERFITRWV DALSDPRLTH EIRTIWLSNW SQADRSLGQK 

       490 
LASRLSAKPS M

P12365 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools