[1]	PROTEIN SEQUENCE. PubMed=8444164 [NCBI, ExPASy, EBI, Israel, Japan] Jeffery J., Persson B., Wood I., Bergman T., Jeffery R., Joernvall H.; "Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure."; Eur. J. Biochem. 212:41-49(1993).
[2]	PROTEIN SEQUENCE OF 177-187. STRAIN=ATCC 9950 / CBS 5609 / DSM 2361 / IFO 0998 / NRRL Y-900; DOI=10.1016/S0006-291X(89)80143-3; PubMed=2499329 [NCBI, ExPASy, EBI, Israel, Japan] Jeffery J., Wood I., McLeod A., Jeffery R., Joernvall H.; "Glucose-6-phosphate dehydrogenase. Characterization of a reactive lysine residue in the Pichia jadinii enzyme reveals a limited structural variation in a functionally significant segment."; Biochem. Biophys. Res. Commun. 160:1290-1295(1989).
[3]	PROTEIN SEQUENCE OF 1-10. DOI=10.1016/0014-5793(96)00657-6; PubMed=8706859 [NCBI, ExPASy, EBI, Israel, Japan] Bergman T., Gheorghe M.T., Hjelmqvist L., Joernvall H.; "Alcoholytic deblocking of N-terminally acetylated peptides and proteins for sequence analysis."; FEBS Lett. 390:199-202(1996).

Comments

CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP⁺ = D-glucono-1,5-lactone 6-phosphate + NADPH.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3 .
SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases
PIR	S11078; S11078. S29381; S29381.
3D structure databases
HSSP	P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase	P11410.
Family and domain databases
InterPro	IPR001282; Glc-6-P_DHase. IPR016040; NAD(P)-bd. Graphical view of domain structure.
Gene3D	G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER	PTHR23429; G6PDH; 1.
Pfam	PF02781; G6PD_C; 1. PF00479; G6PD_N; 1. Pfam graphical view of domain structure.
PIRSF	PIRSF000110; G6PD; 1.
PRINTS	PR00079; G6PDHDRGNASE.
ProDom	PD001129; G6PD; 1. [Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs	TIGR00871; zwf; 1.
PROSITE	PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS	P11410.
Other
ProtoNet	P11410.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Carbohydrate metabolism; Direct protein sequencing; Glucose metabolism; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 495`	`495`	`Glucose-6-phosphate 1-dehydrogenase.`	`PRO_0000068105`
`ACT_SITE`	`241 241`		`Proton acceptor (By similarity).`
`BINDING`	`17 17`		`NADP (By similarity).`
`BINDING`	`49 49`		`NADP (By similarity).`
`BINDING`	`179 179`		`Substrate (By similarity).`
`BINDING`	`183 183`		`Substrate (By similarity).`
`MOD_RES`	`1 1`		`N-acetylserine.`
`VARIANT`	`107 107`	`1`	`H -> G.`
`VARIANT`	`138 138`	`1`	`P -> M.`
`VARIANT`	`416 416`	`1`	`I -> T.`

Sequence information

Length: 495 AA [This is the length of the unprocessed precursor]

Molecular weight: 57029 Da [This is the MW of the unprocessed precursor]

CRC64: B6944216F4B4C8D8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
SYDSFGDRVT IIVFGASGDL ARKKTFPALF GLFREKQLPS TVQIIGYARS HLSDKDFKDY 

        70         80         90        100        110        120 
ISSHFKGGDD KTKEDFLNLC SYISDPYDTD EGYKKLEARC QEYESKHNVK VPERLFYLAL 

       130        140        150        160        170        180 
PPSVFHTVCE QVKKNVYPKN EKSRIIIEKP FGRDLETYRE LQKQISPLFT EDEVYRIDHY 

       190        200        210        220        230        240 
LGKEMVKNLL VLRFGNELFS GIWNNKHITS VQISFKEAFG TEGRGGYFDN IGIIRDVMQN 

       250        260        270        280        290        300 
HLLQVLTLLT MERPVSFDPE AVRDEKVKVL KAFDKIDVND VLLGQYGKSE DGTKPGYLDD 

       310        320        330        340        350        360 
STVKPNSKAV TYAAFRVNIH NERWDGVPIV LRAGKALDEG KAEIRIQFKP VAKGMFKEIQ 

       370        380        390        400        410        420 
RNELVIRIQP NEAIYLKINS KIPGISTETS LTDLDLTYST RYSKDFWIPE AYEALIRDCY 

       430        440        450        460        470        480 
LGNHSNFVRD DELEVSWKLF TPLLEAVEKE ENVKLESYPY GSKGPKELRK YLIDHGYVFN 

       490 
DPGTYQWPLT NTDVK

P11410 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools