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UniProtKB/Swiss-Prot entry P0A9Q7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADHE_ECOLI
Primary accession number P0A9Q7
Secondary accession number P17547
Integrated into Swiss-Prot on July 19, 2005
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 29)
Name and origin of the protein
Protein name Aldehyde-alcohol dehydrogenase
Synonyms None
Includes Alcohol dehydrogenase
     (ADH)
     (EC 1.1.1.1)
Acetaldehyde dehydrogenase [acetylating]
     (ACDH)
     (EC 1.2.1.10)
Pyruvate-formate-lyase deactivase
     (PFL deactivase)
Gene name
Name: adhE
Synonyms: ana
OrderedLocusNames: b1241, JW1228
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-11.
DOI=10.1016/0378-1119(89)90483-6; PubMed=2695398 [NCBI, ExPASy, EBI, Israel, Japan]
Goodlove P.E., Cunningham P.R., Parker J., Clark D.P.;
"Cloning and sequence analysis of the fermentative alcohol-dehydrogenase-encoding gene of Escherichia coli.";
Gene 85:209-214(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-7, AND CHARACTERIZATION.
STRAIN=K12;
DOI=10.1016/0014-5793(91)80358-A; PubMed=2015910 [NCBI, ExPASy, EBI, Israel, Japan]
Kessler D., Leibrecht I., Knappe J.;
"Pyruvate-formate-lyase-deactivase and acetyl-CoA reductase activities of Escherichia coli reside on a polymeric protein particle encoded by adhE.";
FEBS Lett. 281:59-63(1991).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1093/dnares/3.3.137; PubMed=8905232 [NCBI, ExPASy, EBI, Israel, Japan]
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T.;
"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.";
DNA Res. 3:137-155(1996).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 849-891.
STRAIN=K12;
PubMed=7773397 [NCBI, ExPASy, EBI, Israel, Japan]
Danchin A., Krin E.;
"Filling the gap between hns and adhE in Escherichia coli K12.";
Microbiology 141:959-960(1995).
[7]
PROTEIN SEQUENCE OF 2-21.
PubMed=7521508 [NCBI, ExPASy, EBI, Israel, Japan]
Yamato M., Takahashi Y., Tomotake H., Ota F., Hirota K., Yamaguchi K.;
"Monoclonal antibodies to spirosin of Yersinia enterocolitica and analysis of the localization of spirosome by use of them.";
Microbiol. Immunol. 38:177-182(1994).
[8]
ANTIOXIDANT ROLE OF ADHE.
STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
DOI=10.1074/jbc.M304351200; PubMed=12783863 [NCBI, ExPASy, EBI, Israel, Japan]
Echave P., Tamarit J., Cabiscol E., Ros J.;
"Novel antioxidant role of alcohol dehydrogenase E from Escherichia coli.";
J. Biol. Chem. 278:30193-30198(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X59263; CAA41955.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M33504; AAA23420.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC74323.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAA36121.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X67326; CAA47743.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JS0406; DEEC.
RefSeq AP_001865.1; -.
NP_415757.1; -.
3D structure databases
ModBase P0A9Q7.
Protein-protein interaction databases
IntAct P0A9Q7; -.
Enzyme and pathway databases
BioCyc EcoCyc:ADHE-MON; -.
2D gel databases
ECO2DBASE H097.3; 6TH EDITION.
Organism-specific databases
EchoBASE EB0030; -.
EcoGene EG10031; adhE.
Ontologies
GO
GO:0005624; Cellular component: membrane fraction (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR015590; Aldehyde_DHase.
IPR012079; Bifunc_Ald/AlcDHase.
IPR001670; Fe_AlcDHase.
Graphical view of domain structure.
Pfam PF00171; Aldedh; 1.
PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000111; ALDH_ADH; 1.
PROSITE PS00913; ADH_IRON_1; 1.
PS00060; ADH_IRON_2; 1.
BLOCKS P0A9Q7.
Genome annotation databases
GeneID 945837; -.
GenomeReviews U00096_GR; b1241.
AP009048_GR; JW1228.
KEGG ecj:JW1228; -.
eco:b1241; -.
Phylogenomic databases
HOGENOM P0A9Q7; -.
Genome annotation databases
CMR P0A9Q7; b1241.
Other
ProtoNet P0A9Q7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; Iron; Multifunctional enzyme; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   891  890     Aldehyde-alcohol dehydrogenase. PRO_0000087837
NP_BIND   422   427  6     NAD (Potential). 
ACT_SITE   246   246        By similarity. 
Sequence information
Length: 891 AA [This is the length of the unprocessed precursor] Molecular weight: 96127 Da [This is the MW of the unprocessed precursor] CRC64: 75469F57419C8C79 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAVTNVAELN ALVERVKKAQ REYASFTQEQ VDKIFRAAAL AAADARIPLA KMAVAESGMG 

        70         80         90        100        110        120 
IVEDKVIKNH FASEYIYNAY KDEKTCGVLS EDDTFGTITI AEPIGIICGI VPTTNPTSTA 

       130        140        150        160        170        180 
IFKSLISLKT RNAIIFSPHP RAKDATNKAA DIVLQAAIAA GAPKDLIGWI DQPSVELSNA 

       190        200        210        220        230        240 
LMHHPDINLI LATGGPGMVK AAYSSGKPAI GVGAGNTPVV IDETADIKRA VASVLMSKTF 

       250        260        270        280        290        300 
DNGVICASEQ SVVVVDSVYD AVRERFATHG GYLLQGKELK AVQDVILKNG ALNAAIVGQP 

       310        320        330        340        350        360 
AYKIAELAGF SVPENTKILI GEVTVVDESE PFAHEKLSPT LAMYRAKDFE DAVEKAEKLV 

       370        380        390        400        410        420 
AMGGIGHTSC LYTDQDNQPA RVSYFGQKMK TARILINTPA SQGGIGDLYN FKLAPSLTLG 

       430        440        450        460        470        480 
CGSWGGNSIS ENVGPKHLIN KKTVAKRAEN MLWHKLPKSI YFRRGSLPIA LDEVITDGHK 

       490        500        510        520        530        540 
RALIVTDRFL FNNGYADQIT SVLKAAGVET EVFFEVEADP TLSIVRKGAE LANSFKPDVI 

       550        560        570        580        590        600 
IALGGGSPMD AAKIMWVMYE HPETHFEELA LRFMDIRKRI YKFPKMGVKA KMIAVTTTSG 

       610        620        630        640        650        660 
TGSEVTPFAV VTDDATGQKY PLADYALTPD MAIVDANLVM DMPKSLCAFG GLDAVTHAME 

       670        680        690        700        710        720 
AYVSVLASEF SDGQALQALK LLKEYLPASY HEGSKNPVAR ERVHSAATIA GIAFANAFLG 

       730        740        750        760        770        780 
VCHSMAHKLG SQFHIPHGLA NALLICNVIR YNANDNPTKQ TAFSQYDRPQ ARRRYAEIAD 

       790        800        810        820        830        840 
HLGLSAPGDR TAAKIEKLLA WLETLKAELG IPKSIREAGV QEADFLANVD KLSEDAFDDQ 

       850        860        870        880        890 
CTGANPRYPL ISELKQILLD TYYGRDYVEG ETAAKKEAAP AKAEKKAKKS A 

P0A9Q7 in FASTA format

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