[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Placenta; PubMed=2825170 [NCBI, ExPASy, EBI, Israel, Japan] Frielle T., Collins S., Daniel K.W., Caron M.G., Lefkowitz R.J., Kobilka B.K.; "Cloning of the cDNA for the human beta 1-adrenergic receptor."; Proc. Natl. Acad. Sci. U.S.A. 84:7920-7924(1987).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-49 AND GLY-389. DOI=10.1002/(SICI)1098-1004(1999)14:3<271::AID-HUMU14>3.3.CO;2-H; PubMed=10477438 [NCBI, ExPASy, EBI, Israel, Japan] Moore J.D., Mason D.A., Green S.A., Hsu J., Liggett S.B.; "Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C."; Hum. Mutat. 14:271-271(1999).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-49; GLY-389 AND LEU-389. SeattleSNPs program for genomic applications; Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[4]	INTERACTION WITH GOPC AND DLG4, MUTAGENESIS OF GLU-474; SER-475; LYS-476 AND VAL-477, AND SUBCELLULAR LOCATION. DOI=10.1074/jbc.M404876200; PubMed=15358775 [NCBI, ExPASy, EBI, Israel, Japan] He J., Bellini M., Xu J., Castleberry A.M., Hall R.A.; "Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression."; J. Biol. Chem. 279:50190-50196(2004).
[5]	VARIANT GLY-389. DOI=10.1074/jbc.274.18.12670; PubMed=10212248 [NCBI, ExPASy, EBI, Israel, Japan] Mason D.A., Moore J.D., Green S.A., Liggett S.B.; "A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor."; J. Biol. Chem. 274:12670-12674(1999).
[6]	VARIANT GLY-49. DOI=10.1053/euhj.1999.1994; PubMed=11052857 [NCBI, ExPASy, EBI, Israel, Japan] Borjesson M., Magnusson Y., Hjalmarson A., Andersson B.; "A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure."; Eur. Heart J. 21:1853-1858(2000).
[7]	VARIANT GLY-49. DOI=10.1086/339621; PubMed=11854867 [NCBI, ExPASy, EBI, Israel, Japan] Ranade K., Jorgenson E., Sheu W.H.-H., Pei D., Hsiung C.A., Chiang F.-T., Chen Y.-D.I., Pratt R., Olshen R.A., Curb D., Cox D.R., Botstein D., Risch N.; "A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate."; Am. J. Hum. Genet. 70:935-942(2002).

Comments

FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
SUBUNIT: Interacts with GOPC and DLG4.
INTERACTION:
Q9HBC4:-; NbExp=4; IntAct=EBI-991009, EBI-991068;
Q62696:Dlg1 (xeno); NbExp=1; IntAct=EBI-991009, EBI-389325;
P31016:Dlg4 (xeno); NbExp=1; IntAct=EBI-991009, EBI-375655;
Q9Z254:Gipc1 (xeno); NbExp=1; IntAct=EBI-991009, EBI-991162;
Q9HD26:GOPC; NbExp=1; IntAct=EBI-991009, EBI-349832;
Q96QZ7:MAGI1; NbExp=1; IntAct=EBI-991009, EBI-924464;
Q86UL8:MAGI2; NbExp=1; IntAct=EBI-991009, EBI-311035;
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.
DOMAIN: The PDZ domain-binding motif mediates competitive interactions with GOPC and DLG4 and plays a role in subcellular location of the receptor.
PTM: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/adrb1/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

J03019; AAA51667.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF169006; AAD53696.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF169007; AAD53697.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY567837; AAS66983.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A39911; QRHUB1.

UniGene

Hs.695932

3D structure databases

ModBase

P08588.

Protein-protein interaction databases

IntAct

P08588; -.

Protein family/group databases

GPCRDB

P08588; ADRB1_HUMAN.

PTM databases

PhosphoSite

P08588; -.

Organism-specific databases

HIX0035626; -.

HGNC:285; ADRB1.

ADRB1; Homo sapiens.

109630; gene. [NCBI / EBI]
607276; phenotype. [NCBI / EBI]

PharmGKB

PA38; -.

GeneCards

P08588.

Gene expression databases

ArrayExpress

P08588; -.

CleanEx

HS_ADRB1; -.

GermOnline

ENSG00000043591; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004940;	Molecular function: beta1-adrenergic receptor activity (traceable author statement from ProtInc).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0007190;	Biological process: activation of adenylate cyclase activity (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR000507; Adrgc_rcpt_B1.
IPR002233; Adrnrgc_rcpt.
IPR000276; GPCR_Rhodpsn.
Graphical view of domain structure.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR01103; ADRENERGICR.
PR00561; ADRENRGCB1AR.
PR00237; GPCRRHODOPSN.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P08588.

Genome annotation databases

Ensembl

ENSG00000043591; Homo sapiens. [Contig view]

Other

DrugBank

DB01193; Acebutolol.
DB00866; Alprenolol.
DB01118; Amiodarone.
DB01102; Arbutamine.
DB00335; Atenolol.
DB00195; Betaxolol.
DB01295; Bevantolol.
DB00612; Bisoprolol.
DB01158; Bretylium.
DB00521; Carteolol.
DB01136; Carvedilol.
DB01151; Desipramine.
DB00841; Dobutamine.
DB00988; Dopamine.
DB00668; Epinephrine.
DB00187; Esmolol.
DB00221; Isoetharine.
DB01064; Isoproterenol.
DB00598; Labetalol.
DB01210; Levobunolol.
DB01214; Metipranolol.
DB00264; Metoprolol.
DB01203; Nadolol.
DB00368; Norepinephrine.
DB01580; Oxprenolol.
DB01359; Penbutolol.
DB00960; Pindolol.
DB01297; Practolol.
DB00571; Propranolol.
DB00734; Risperidone.
DB00373; Timolol.
DB00246; Ziprasidone.

ADRB1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 477`	`477`	`Beta-1 adrenergic receptor.`	`PRO_0000069118`
`TOPO_DOM`	`1 59`	`59`	`Extracellular (Potential).`
`TRANSMEM`	`60 83`	`24`	`1 (Potential).`
`TOPO_DOM`	`84 96`	`13`	`Cytoplasmic (Potential).`
`TRANSMEM`	`97 120`	`24`	`2 (Potential).`
`TOPO_DOM`	`121 131`	`11`	`Extracellular (Potential).`
`TRANSMEM`	`132 155`	`24`	`3 (Potential).`
`TOPO_DOM`	`156 175`	`20`	`Cytoplasmic (Potential).`
`TRANSMEM`	`176 199`	`24`	`4 (Potential).`
`TOPO_DOM`	`200 221`	`22`	`Extracellular (Potential).`
`TRANSMEM`	`222 245`	`24`	`5 (Potential).`
`TOPO_DOM`	`246 325`	`80`	`Cytoplasmic (Potential).`
`TRANSMEM`	`326 349`	`24`	`6 (Potential).`
`TOPO_DOM`	`350 356`	`7`	`Extracellular (Potential).`
`TRANSMEM`	`357 380`	`24`	`7 (Potential).`
`TOPO_DOM`	`381 477`	`97`	`Cytoplasmic (Potential).`
`MOTIF`	`474 477`	`4`	`PDZ-Binding.`
`MOD_RES`	`312 312`		`Phosphoserine; by PKA (Potential).`
`MOD_RES`	`412 412`		`Phosphoserine; by PKA (Potential).`
`LIPID`	`392 392`		`S-palmitoyl cysteine (By similarity).`
`CARBOHYD`	`15 15`		`N-linked (GlcNAc...) (Probable).`
`DISULFID`	`131 209`		`By similarity.`
`VARIANT`	`49 49`	`1`	`S -> G (associated with high mean resting heart rate; dbSNP:rs1801252 [NCBI]).`	`VAR_009879`
`VARIANT`	`389 389`	`1`	`R -> G (reduced binding to G proteins; dbSNP:rs1801253 [NCBI]).`	`VAR_009880`
`VARIANT`	`389 389`	`1`	`R -> L.`	`VAR_018742`
`MUTAGEN`	`474 474`		`E->A,D: Loss of interaction with GOPC.`
`MUTAGEN`	`474 474`		`E->K: Loss of interaction with GOPC; when associated with A-477.`
`MUTAGEN`	`475 475`		`S->A: Loss of interaction with GOPC.`
`MUTAGEN`	`475 475`		`S->T: Partial loss of interaction with GOPC.`
`MUTAGEN`	`476 476`		`K->A: Partial loss of interaction with GOPC.`
`MUTAGEN`	`477 477`		`V->A,F,L,I,M: Loss of interaction with GOPC.`

Sequence information

Length: 477 AA [This is the length of the unprocessed precursor]

Molecular weight: 51323 Da [This is the MW of the unprocessed precursor]

CRC64: 0950F2684E4721B8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP EPLSQQWTAG 

        70         80         90        100        110        120 
MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV 

       130        140        150        160        170        180 
WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARGLVC 

       190        200        210        220        230        240 
TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM 

       250        260        270        280        290        300 
AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPSPSPV PAPAPPPGPP RPAAAAATAP 

       310        320        330        340        350        360 
LANGRAGKRR PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH RELVPDRLFV 

       370        380        390        400        410        420 
FFNWLGYANS AFNPIIYCRS PDFRKAFQRL LCCARRAARR RHATHGDRPR ASGCLARPGP 

       430        440        450        460        470 
PPSPGAASDD DDDDVVGATP PARLLEPWAG CNGGAAADSD SSLDEPCRPG FASESKV

P08588 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools