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UniProtKB/Swiss-Prot entry P07492


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GRP_HUMAN
Primary accession number P07492
Secondary accession numbers P07491 P81553 Q14454 Q9BSY7
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on April 1, 1988 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 84)
Name and origin of the protein
Protein name Gastrin-releasing peptide [Precursor]
Synonym GRP
Contains Neuromedin-C
     (GRP-10)
Gene name
Name: GRP
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
PubMed=3001723 [NCBI, ExPASy, EBI, Israel, Japan]
Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W.;
"Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides.";
Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT MET-50.
PubMed=3211139 [NCBI, ExPASy, EBI, Israel, Japan]
Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G., van Wyke Coelingh K., Lebacq J.A., Battey J.F.;
"Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor.";
Mol. Cell. Biol. 8:3129-3135(1988).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
PubMed=3003116 [NCBI, ExPASy, EBI, Israel, Japan]
Sausville E.A., Lebacq-Verheyden A.M., Spindel E.R., Cuttitta F., Gazdar A.F., Battey J.F.;
"Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs.";
J. Biol. Chem. 261:2451-2457(1986).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-4.
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
K02054; AAA52613.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12550; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
M12512; AAA52612.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12511; AAA52612.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12512; AAA52611.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M12511; AAA52611.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC004488; AAH04488.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A26182; A26182.
B26182; B26182.
RefSeq NP_001012530.1; -.
NP_001012531.1; -.
NP_002082.2; -.
UniGene Hs.153444
3D structure databases
ModBase P07492.
Organism-specific databases
HGNC HGNC:4605; GRP.
GenAtlas GRP.
HPA HPA007314; -.
MIM 137260; gene. [NCBI / EBI]
PharmGKB PA24627; -.
GeneCards P07492.
Gene expression databases
ArrayExpress P07492; -.
CleanEx HS_GRP; -.
GermOnline ENSG00000134443; Homo sapiens.
Ontologies
GO
GO:0005102; Molecular function: receptor binding (non-traceable author statement from ProtInc).
GO:0007165; Biological process: signal transduction (non-traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000874; Bombesin.
IPR015674; Gastrin-RP.
Graphical view of domain structure.
PANTHER PTHR16866; Gastrin-RP; 1.
Pfam PF02044; Bombesin; 1.
Pfam graphical view of domain structure.
PROSITE PS00257; BOMBESIN; 1.
BLOCKS P07492.
Genome annotation databases
Ensembl ENSG00000134443; Homo sapiens. [Contig view]
GeneID 2922; -.
KEGG hsa:2922; -.
Phylogenomic databases
HOGENOM P07492; -.
HOVERGEN P07492; -.
Other
SOURCE GRP; Homo sapiens.
ProtoNet P07492.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Amidation; Cleavage on pair of basic residues; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    23  23      
PEPTIDE   24    50  27     Gastrin-releasing peptide. PRO_0000003035
PEPTIDE   41    50  10     Neuromedin-C. PRO_0000003036
PROPEP   54   148  95      PRO_0000003037
MOD_RES   50    50        Methionine amide. 
VAR_SEQ   122   148        VGSKGKVGRLSAPGSQREGRNPQLNQQ -> LVDSLLQVLNVKEGTPS (in isoform 2). VSP_000549
VAR_SEQ   128   134        Missing (in isoform 3). VSP_000550
VARIANT   4     4  1     S -> R (in dbSNP:rs1062557 [NCBI]). VAR_027834 
Sequence information
Length: 148 AA [This is the length of the unprocessed precursor] Molecular weight: 16144 Da [This is the MW of the unprocessed precursor] CRC64: 2B55B93904825466 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRGSELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 

        70         80         90        100        110        120 
VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 

       130        140 
DVGSKGKVGR LSAPGSQREG RNPQLNQQ 

P07492 in FASTA format

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