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UniProtKB/Swiss-Prot entry P00368

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHE3_CHICK
Primary accession number P00368
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 64)
Name and origin of the protein
Protein name Glutamate dehydrogenase 1, mitochondrial
Synonyms GDH
EC 1.4.1.3
Gene name
Name: GLUD1
Synonyms: GLUD
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 1: Evidence at protein level;
References
[1]
 PROTEIN SEQUENCE, AND ACTIVE SITE.
TISSUE=Liver;
PubMed=4735574 [NCBI, ExPASy, EBI, Israel, Japan]
Moon K., Piszkiewicz D., Smith E.L.;
"Amino acd sequence of chicken liver glutamate dehydrogenase.";
J. Biol. Chem. 248:3093-3107(1973).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
PIR A00380; DECHE.
UniGene Gga.16450
3D structure databases
HSSP P00366; 1HWX. [HSSP ENTRY / PDB]
SMR P00368; 4-503.
ModBase P00368.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11606:SF2; GLFV_DH; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000185; Glu_DH; 1.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
BLOCKS P00368.
Genome annotation databases
Ensembl ENSGALG00000002020; Gallus gallus. [Contig view]
Phylogenomic databases
HOGENOM P00368; -.
HOVERGEN P00368; -.
Other
ProtoNet P00368.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Direct protein sequencing; GTP-binding; Mitochondrion; NADP; Nucleotide-binding; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   503  503     Glutamate dehydrogenase 1, mitochondrial. PRO_0000182742
NP_BIND   87    89  3     NAD (By similarity). 
ACT_SITE   129   129         
BINDING   93    93        Substrate (By similarity). 
BINDING   117   117        Substrate (By similarity). 
BINDING   122   122        NAD (By similarity). 
BINDING   198   198        NAD (By similarity). 
BINDING   212   212        GTP (By similarity). 
BINDING   216   216        GTP (By similarity). 
BINDING   265   265        GTP (By similarity). 
BINDING   268   268        GTP (By similarity). 
BINDING   384   384        Substrate (By similarity). 
BINDING   389   389        NAD (By similarity). 
BINDING   395   395        ADP (By similarity). 
BINDING   461   461        ADP (By similarity). 
Sequence information
Length: 503 AA [This is the length of the unprocessed precursor] Molecular weight: 55712 Da [This is the MW of the unprocessed precursor] CRC64: 340DDB45BB0A5B04 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
CZAADKEDDP NFFKMVEGFF DRGASIVEDK LVEGLRTRQS MEQRRHRVRG ILRIIKPCNH 

        70         80         90        100        110        120 
VLSVSFPIKR DDGZWEVIEG YRAQHSHQRT PCKGGIRYSL DVSVDEVKAL ASLMTYKCAV 

       130        140        150        160        170        180 
VDVPFGGAKA GVKINPKNYT DEDLEKITRR FTMELAKKGF IGPGVDVPAP NMSTGEREMS 

       190        200        210        220        230        240 
WIADTYASTI GHYDINAHAC VTKPGISQGG IHGRISATGR GLFGHIENFI ENASYMSILG 

       250        260        270        280        290        300 
MTPGFGDKTF AVQGFGNVGL HSMRYLHRFG AKCVAVGEFD GSIWNPDGID PKELEDYKLQ 

       310        320        330        340        350        360 
HGTIMGFPKA QKLEGSILET DCDILIPAAS EKQLTKANAH KVKAKIIAEG ANGPTTPQAD 

       370        380        390        400        410        420 
KIFLERNIMV IPDLYLNAGG VTVSAFZZKN LNHVSYGRLT FKYERDSNYH LLMSVQESLE 

       430        440        450        460        470        480 
RKFGKHGGTI PVVPTAEFQD RISGASEKDI VHSGLAYTME RSARQIMRTA MKYNLGLDLR 

       490        500 
TAAYVNAIEK VFKVYNEAGL TFT
P00368 in FASTA format

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