[1]
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NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH DCC, TISSUE SPECIFICITY, AND VARIANTS HIS-351 AND GLU-489.
TISSUE=Brain stem, and Liver;
PubMed=9950216 [NCBI, ExPASy, EBI, Israel, Japan]
Meyerhardt J.A.,
Caca K.,
Eckstrand B.C.,
Hu G.,
Lengauer C.,
Banavali S.,
Look A.T.,
Fearon E.R.;
"Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.";
Cell Growth Differ. 10:35-42(1999).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04689; PubMed=16625196 [NCBI, ExPASy, EBI, Israel, Japan]
Zody M.C.,
Garber M.,
Adams D.J.,
Sharpe T.,
Harrow J.,
Lupski J.R.,
Nicholson C.,
Searle S.M.,
Wilming L.,
Young S.K.,
Abouelleil A.,
Allen N.R.,
Bi W.,
Bloom T.,
Borowsky M.L.,
Bugalter B.E.,
Butler J.,
Chang J.L.,
Chen C.-K., ![]()
Cook A.,
Corum B.,
Cuomo C.A.,
de Jong P.J.,
DeCaprio D.,
Dewar K.,
FitzGerald M.,
Gilbert J.,
Gibson R.,
Gnerre S.,
Goldstein S.,
Grafham D.V.,
Grocock R.,
Hafez N.,
Hagopian D.S.,
Hart E.,
Norman C.H.,
Humphray S.,
Jaffe D.B.,
Jones M.,
Kamal M.,
Khodiyar V.K.,
LaButti K.,
Laird G.,
Lehoczky J.,
Liu X.,
Lokyitsang T.,
Loveland J.,
Lui A.,
Macdonald P.,
Major J.E.,
Matthews L.,
Mauceli E.,
McCarroll S.A.,
Mihalev A.H.,
Mudge J.,
Nguyen C.,
Nicol R.,
O'Leary S.B.,
Osoegawa K.,
Schwartz D.C.,
Shaw-Smith C.,
Stankiewicz P.,
Steward C.,
Swarbreck D.,
Venkataraman V.,
Whittaker C.A.,
Yang X.,
Zimmer A.R.,
Bradley A.,
Hubbard T.,
Birren B.W.,
Rogers J.,
Lander E.S.,
Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.";
Nature 440:1045-1049(2006).
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[3]
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FUNCTION.
DOI=10.1038/nature02788; PubMed=15343335 [NCBI, ExPASy, EBI, Israel, Japan]
Mazelin L.,
Bernet A.,
Bonod-Bidaud C.,
Pays L.,
Arnaud S.,
Gespach C.,
Bredesen D.E.,
Scoazec J.-Y.,
Mehlen P.;
"Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.";
Nature 431:80-84(2004).
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- FUNCTION: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis.
- SUBUNIT: Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D.
- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
- TISSUE SPECIFICITY: Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas.
- DISEASE: Defects in NTN1 are associated with some forms of neuroblastomas.
- SIMILARITY: Contains 3 laminin EGF-like domains.
- SIMILARITY: Contains 1 laminin N-terminal domain.
- SIMILARITY: Contains 1 NTR domain.
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