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UniProtKB/Swiss-Prot entry O94921


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PFTK1_HUMAN
Primary accession number O94921
Secondary accession numbers A6NK51 Q75N06 Q75N22 Q8N764 Q9H3D7 Q9UDR0
Integrated into Swiss-Prot on August 30, 2002
Sequence was last modified on April 18, 2006 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 76)
Name and origin of the protein
Protein name Serine/threonine-protein kinase PFTAIRE-1
Synonym EC 2.7.11.22
Gene name
Name: PFTK1
Synonyms: KIAA0834
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
TISSUE=Cervix carcinoma;
DOI=10.1016/S0378-1119(01)00391-2; PubMed=11313143 [NCBI, ExPASy, EBI, Israel, Japan]
Yang T., Chen J.-Y.;
"Identification and cellular localization of human PFTAIRE1.";
Gene 267:165-172(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
DOI=10.1093/dnares/5.6.355; PubMed=10048485 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 5:355-364(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01782; PubMed=12853948 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF119833; AAG43234.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB020641; BAA74857.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC000057; AAS07411.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC000059; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC002065; AAM48566.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC002456; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC002458; AAS07412.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC006036; AAF19245.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_036527.1; -.
UniGene Hs.430742
3D structure databases
HSSP P24941; 1GII. [HSSP ENTRY / PDB]
ModBase O94921.
Protein-protein interaction databases
IntAct O94921; -.
PTM databases
PhosphoSite O94921; -.
Organism-specific databases
HGNC HGNC:8883; PFTK1.
GenAtlas PFTK1.
HPA HPA015267; -.
MIM 610679; gene. [NCBI / EBI]
PharmGKB PA33221; -.
GeneCards O94921.
HUGE KIAA0834.
Gene expression databases
ArrayExpress O94921; -.
CleanEx HS_PFTK1; -.
GermOnline ENSG00000058091; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (traceable author statement from ProtInc).
GO:0005634; Cellular component: nucleus (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.
Pfam PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00220; S_TKc; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O94921.
Genome annotation databases
Ensembl ENSG00000058091; Homo sapiens. [Contig view]
GeneID 5218; -.
KEGG hsa:5218; -.
Phylogenomic databases
HOGENOM O94921; -.
HOVERGEN O94921; -.
Other
SOURCE PFTK1; Homo sapiens.
ProtoNet O94921.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Serine/threonine-protein kinase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   469  469     Serine/threonine-protein kinase PFTAIRE-1. PRO_0000086506
DOMAIN   135   419  285     Protein kinase. 
NP_BIND   141   149  9     ATP (By similarity). 
ACT_SITE   256   256        Proton acceptor (By similarity). 
BINDING   164   164        ATP (By similarity). 
VAR_SEQ   1    41        MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDD TTFDE -> MHGYFGCNAAAEPGYSAFVGTPQ (in isoform 2). VSP_004803
CONFLICT   158   158        G -> W (in Ref. 1; AAG43234). 
Sequence information
Length: 469 AA [This is the length of the unprocessed precursor] Molecular weight: 53057 Da [This is the MW of the unprocessed precursor] CRC64: 32CF9B9B7BD9CE0E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MCDLIEPQPA EKIGKMKKLR RTLSESFSRI ALKKDDTTFD EICVTKMSTR NCQGMDSVIK 

        70         80         90        100        110        120 
PLDTIPEDKK VRVQRTQSTF DPFEKPANQV KRVHSENNAC INFKTSSTGK ESPKVRRHSS 

       130        140        150        160        170        180 
PSSPTSPKFG KADSYEKLEK LGEGSYATVY KGKSKVNGKL VALKVIRLQE EEGTPFTAIR 

       190        200        210        220        230        240 
EASLLKGLKH ANIVLLHDII HTKETLTLVF EYVHTDLCQY MDKHPGGLHP DNVKLFLFQL 

       250        260        270        280        290        300 
LRGLSYIHQR YILHRDLKPQ NLLISDTGEL KLADFGLARA KSVPSHTYSN EVVTLWYRPP 

       310        320        330        340        350        360 
DVLLGSTEYS TCLDMWGVGC IFVEMIQGVA AFPGMKDIQD QLERIFLVLG TPNEDTWPGV 

       370        380        390        400        410        420 
HSLPHFKPER FTLYSSKNLR QAWNKLSYVN HAEDLASKLL QCSPKNRLSA QAALSHEYFS 

       430        440        450        460 
DLPPRLWELT DMSSIFTVPN VRLQPEAGES MRAFGKNNSY GKSLSNSKH 

O94921 in FASTA format

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View entry in raw text format (no links)
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