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UniProtKB/Swiss-Prot entry O89000

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DPYD_RAT
Primary accession number O89000
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 51)
Name and origin of the protein
Protein name Dihydropyrimidine dehydrogenase [NADP+]
Synonyms DHPDHase
DPD
EC 1.3.1.2
Dihydrouracil dehydrogenase
Dihydrothymine dehydrogenase
Gene name
Name: Dpyd
Synonyms: DPD
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar;
TISSUE=Liver;
PubMed=9819714 [NCBI, ExPASy, EBI, Israel, Japan]
Kimura M., Fujimoto Sakata S., Matoba Y., Matsuda K., Kontani Y., Kaneko M., Tamaki N.;
"Cloning of rat dihydropyrimidine dehydrogenase and correlation of its mRNA increase in the rat liver with age.";
J. Nutr. Sci. Vitaminol. 44:537-546(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D85035; BAA33218.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_112289.1; -.
UniGene Rn.158382
3D structure databases
HSSP Q28943; 1H7X. [HSSP ENTRY / PDB]
SMR O89000; 2-1017.
ModBase O89000.
Organism-specific databases
RGD 621218; Dpyd.
Gene expression databases
ArrayExpress O89000; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0017113; Molecular function: dihydropyrimidine dehydrogenase (NADP+) activity (inferred from direct assay from UniProtKB).
GO:0050661; Molecular function: NADP binding (inferred from direct assay from UniProtKB).
GO:0042803; Molecular function: protein homodimerization activity (inferred from direct assay from UniProtKB).
GO:0006214; Biological process: thymidine catabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006212; Biological process: uracil catabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR000759; Adrndx_reductase.
IPR013785; Aldolase_TIM.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR012285; Fum_reductase_C.
IPR016040; NAD(P)-bd.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01180; DHO_dh; 1.
PF00037; Fer4; 1.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00469; PNDRDTASEII.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 3.
PROSITE graphical view of domain structure (profiles).
BLOCKS O89000.
Genome annotation databases
Ensembl ENSRNOG00000017105; Rattus norvegicus. [Contig view]
GeneID 81656; -.
KEGG rno:81656; -.
Phylogenomic databases
HOVERGEN O89000; -.
Other
ProtoNet O89000.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Cytoplasm; FAD; Flavoprotein; FMN; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1025  1025     Dihydropyrimidine dehydrogenase [NADP+]. PRO_0000327502
DOMAIN   69    100  32     4Fe-4S ferredoxin-type 1. 
DOMAIN   944    976  33     4Fe-4S ferredoxin-type 2. 
DOMAIN   978   1007  30     4Fe-4S ferredoxin-type 3. 
METAL   953    953        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   956    956        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   959    959        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   963    963        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   986    986        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   989    989        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   992    992        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   996    996        Iron-sulfur 2 (4Fe-4S) (Potential). 
MOD_RES   577    577        Phosphoserine (By similarity). 
Sequence information
Length: 1025 AA [This is the length of the unprocessed precursor] Molecular weight: 111468 Da [This is the MW of the unprocessed precursor] CRC64: 07859E73D249828C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGVLSRDAP DIESILALNP RIQAHATLRS TMAKKLDKKH WKRNTDKNCF ICEKLENNFD 

        70         80         90        100        110        120 
DIKHTTLGER GALREAVRCL KCADAPCQKS CPTSLDIKSF ITSIANKNYY GAAKLIFSDN 

       130        140        150        160        170        180 
PLGLTCGMVC PTSDLCVGGC NLHATEEGPI NIGGLQQFAT EVFKAMNIPQ IRSPLLPPPE 

       190        200        210        220        230        240 
HMPEAYSAKI ALFGAGPASI SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV 

       250        260        270        280        290        300 
VNFEIELMKD LGVKIICGKS ISTDEMTLST LKENGYKAAF IGIGLPEPKK DHIFQGLTQV 

       310        320        330        340        350        360 
QGFYTSKDFL PLVAKGSKPG MCACHSPLPS VRGAVIVLGA GDTAFDCATS ALRCGARRVF 

       370        380        390        400        410        420 
IVFRKGFANI RAVPEEMELA KEEKCEFLPF LSPRKVIVKD GKIVGMQFVR TEQDETGNWV 

       430        440        450        460        470        480 
EDEEQIVRLK ADVVISPFGS VLDDPKVIEA LSPIKFNRWG LPEVNPETMQ TSEPWVFAGG 

       490        500        510        520        530        540 
DVVGMANTTV ESVNDGKQAS WYIHEYIQAQ YGALVPSQPT LPLFYTPVDL VDISVEMAGL 

       550        560        570        580        590        600 
RFPNPFGLAS ATPATSTPMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPLY 

       610        620        630        640        650        660 
GPGQSSFLNI ELISEKTAAY WCHSVTELKA DFPDNILIAS IMCSYNKNDW MELSKMAEAS 

       670        680        690        700        710        720 
GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ SVRVPFFAKL TPNVTDIVSI 

       730        740        750        760        770        780 
ARAAKEGGAD GVTATNTVSG LMGLKADGSP WPSVGSGKRT TYGGVSGTTI RPIALRAVTA 

       790        800        810        820        830        840 
IARALPGFPI LATGGIDSAE SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL 

       850        860        870        880        890        900 
KSIEELSDWD GQSPPTMSHQ KGKPVPHIAE LMGQKLPSFG PYLERRKKIL AASKIRENDQ 

       910        920        930        940        950        960 
NRACSPLQRK HFNSQKPIPA IKDVIGKSLQ YLGTFGELNI MEQVVALIDE EMCINCGKCY 

       970        980        990       1000       1010       1020 
MTCNDSGYQA IQFDPETHLP TVSDTCTGCT LCLSVCPIMD CIRMVSRATP YEPKRGLPLA 


VKPVC
O89000 in FASTA format

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