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UniProtKB/Swiss-Prot entry O88833


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP4AA_MOUSE
Primary accession number O88833
Secondary accession number Q9DCS5
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 62)
Name and origin of the protein
Protein name Cytochrome P450 4A10
Synonyms EC 1.14.15.3
CYPIVA10
Lauric acid omega-hydroxylase
P450-LA-omega 1
P452
Gene name
Name: Cyp4a10
Synonyms: Cyp4a-10
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6;
TISSUE=Liver;
PubMed=8031839 [NCBI, ExPASy, EBI, Israel, Japan]
Henderson C.J., Bammler T., Wolf C.R.;
"Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.";
Biochim. Biophys. Acta 1200:182-190(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=ddY;
TISSUE=Liver;
Yasumura N., Ikeda T.;
"Polymorphism of cyp 4A10 sequence between C57BL/6 and ddY mouse.";
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Kidney;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
  • FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
  • CATALYTIC ACTIVITY: Octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O.
  • COFACTOR: Heme group (By similarity).
  • SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • SIMILARITY: Belongs to the cytochrome P450 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X69296; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
AB018421; BAA33804.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK002528; BAB22165.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC010747; AAH10747.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC051049; AAH51049.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S47553; S47553.
RefSeq NP_034141.2; -.
UniGene Mm.10742
3D structure databases
ModBase O88833.
Organism-specific databases
MGI MGI:88611; Cyp4a10.
Gene expression databases
ArrayExpress O88833; -.
GermOnline ENSMUSG00000066072; Mus musculus.
Ontologies
GO
GO:0005792; Cellular component: microsome (inferred from direct assay from UniProtKB).
GO:0006631; Biological process: fatty acid metabolic process (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS O88833.
Genome annotation databases
Ensembl ENSMUSG00000066072; Mus musculus. [Contig view]
GeneID 13117; -.
KEGG mmu:13117; -.
Phylogenomic databases
HOGENOM O88833; -.
HOVERGEN O88833; -.
Other
SOURCE Cyp4a10; Mus musculus.
ProtoNet O88833.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   509  509     Cytochrome P450 4A10. PRO_0000051815
METAL   456   456        Iron (heme axial ligand) (By similarity). 
BINDING   320   320        Heme (covalent; via 1 link) (By similarity). 
CONFLICT   62    62        H -> L (in Ref. 1; X69296). 
CONFLICT   64    64        Q -> K (in Ref. 1; X69296 and 3; BAB22165). 
CONFLICT   69    69        H -> Q (in Ref. 1; X69296 and 3; BAB22165). 
CONFLICT   234   234        I -> N (in Ref. 1; X69296). 
Sequence information
Length: 509 AA [This is the length of the unprocessed precursor] Molecular weight: 58339 Da [This is the MW of the unprocessed precursor] CRC64: 0D679AC757D8EB10 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSVSALSPTR FADSLSGFLQ VASVLGLLLL LVKAVQFYLH RQWLLKAFQQ FPSPPFHWFF 

        70         80         90        100        110        120 
GHEQFKGDHE LQEIVSCIEN FPSAFPRWFW GSKAYLTVYD PDYMKVILGR SDPKANGAYR 

       130        140        150        160        170        180 
LLAPWIGYGL LLLNGQPWFQ HRRMLTPAFH YDILKPYVKN MADSIRLMLD KWERLADQDS 

       190        200        210        220        230        240 
SIEIFQHISL MTLDTVMKCA FSHKGSVQVD GNYRTYLQAI GDLNNLFHSR VRNIFHQNDT 

       250        260        270        280        290        300 
IYKLSSNGRL AKQACQLAHD HTDGVIKLRK DQLQDEGELE KIKKKRRLDF LDILLFARME 

       310        320        330        340        350        360 
NGDSMSDKDL RAEVDTFMFE GHDTTASGVS WIFYALATHP DHQQRCREEV QSLLGDGSSI 

       370        380        390        400        410        420 
TWDHLDQIPY TTMCIKEALR LYPPVPGIVR ELSTSVTFPD GRSLPKGVQV TLSIYGLHHN 

       430        440        450        460        470        480 
PKVWPNPEVF DPSRFAPDSP RHSHSFLPFS GGARNCIGKQ FAMSELKVIV ALTLLRFELL 

       490        500 
PDPTRVPMPL ARLVLKSKNG IYLHLKKLH 

O88833 in FASTA format

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