Peptide methionine sulfoxide reductase msrB
     (EC 1.8.4.12)
     (Peptide-methionine (R)-S-oxide reductase)
Peptide methionine sulfoxide reductase msrA
     (Protein-methionine-S-oxide reductase)
     (EC 1.8.4.11)
     (Peptide-methionine (S)-S-oxide reductase)
     (Peptide Met(O) reductase)

Gene name

	Name:	msrAB
	Synonyms:	msrA
	OrderedLocusNames:	TP_0633

From

Treponema pallidum

[TaxID: 160]

[HAMAP proteome]

Taxonomy

Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.

Protein existence

3: Inferred from homology;

References

[1]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Nichols;
DOI=10.1126/science.281.5375.375; PubMed=9665876 [NCBI, ExPASy, EBI, Israel, Japan]
Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C.;
"Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
Science 281:375-388(1998).

Comments

FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (R)-S-oxide + thioredoxin.
CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H₂O = L-methionine (S)-S-oxide + thioredoxin.
SIMILARITY: In the N-terminal section; belongs to the msrB Met sulfoxide reductase family.
SIMILARITY: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE000520; AAC65608.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

G71300; G71300.

RefSeq

NP_219071.1; -.

3D structure databases

HSSP

P14930; 1L1D. [HSSP ENTRY / PDB]

ModBase

O83641.

Enzyme and pathway databases

BioCyc

TPAL243276:TP_0633-MON; -.

Ontologies

GO:0008113;	Molecular function: peptide-methionine-(S)-S-oxide reductase activity (inferred from electronic annotation from HAMAP).
GO:0006464;	Biological process: protein modification process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01400; fused; 1.
MF_01401; fused; 1.
PBIL [Tree]

InterPro

IPR002569; MsrA.
IPR002579; MsrB.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.1060.10; MsrA; 1.

Pfam

PF01625; PMSR; 1.
PF01641; SelR; 1.
Pfam graphical view of domain structure.

ProDom

PD004057; DUF25; 1.
PD003489; PMSR; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00401; msrA; 1.
TIGR00357; MsrB; 1.

BLOCKS

O83641.

Genome annotation databases

GeneID

2611495; -.

GenomeReviews

AE000520_GR; TP_0633.

KEGG

tpa:TP0633; -.

NMPDR

fig|243276.1.peg.630; -.

TIGR

TP_0633; -.

Phylogenomic databases

HOGENOM

O83641; -.

Other

ProtoNet

O83641.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Multifunctional enzyme; Oxidoreductase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 291`	`291`	`Peptide methionine sulfoxide reductase msrB/msrA.`	`PRO_0000138525`
`REGION`	`1 124`	`124`	`Peptide methionine sulfoxide reductase B.`
`REGION`	`127 284`	`158`	`Peptide methionine sulfoxide reductase A.`
`ACT_SITE`	`113 113`		`By similarity.`
`ACT_SITE`	`135 135`		`By similarity.`

Sequence information

Length: 291 AA [This is the length of the unprocessed precursor]

Molecular weight: 32802 Da [This is the MW of the unprocessed precursor]

CRC64: 3FF46CC8D37E8C15 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLANLQHLSD IQYRVTQQSA TETPFKNEFW NSYQPGFYLD VVSGELLFLS EDKFDSGCGW 

        70         80         90        100        110        120 
PSFSAPAYAR AVIEKEDRTH NMLRTEVRSR NANSHLGHVF KDGPPERGGL RYCINSAALR 

       130        140        150        160        170        180 
FVAREEGTAL FAAGCFWSTE AYFRRVKGVL RVRVGYTGGT TKSPTYRNVC TGTTGHAEAV 

       190        200        210        220        230        240 
EILFDPQVIS YEDLLKHFFR MHDPTSLNKQ GGDVGTQYRS AIFYLSGTQK QQAETLMGRY 

       250        260        270        280        290 
AGAGKFTRPL VTTLEEARDF YPAEEYHQDY LTKNPGGYCH VSLHLASEPL E

O83641 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools