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UniProtKB/Swiss-Prot entry O80434


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LAC4_ARATH
Primary accession number O80434
Secondary accession number Q940U7
Integrated into Swiss-Prot on April 3, 2007
Sequence was last modified on June 1, 2002 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 52)
Name and origin of the protein
Protein name Laccase-4 [Precursor]
Synonyms EC 1.10.3.2
Benzenediol:oxygen oxidoreductase 4
Urishiol oxidase 4
Diphenol oxidase 4
Protein IRREGULAR XYLEM 12
Gene name
Name: IRX12
Synonyms: LAC4
OrderedLocusNames: At2g38080
ORFNames: F16M14.1
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/45471; PubMed=10617197 [NCBI, ExPASy, EBI, Israel, Japan]
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
Nature 402:761-768(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[3]
FUNCTION.
DOI=10.1105/tpc.105.031542; PubMed=15980264 [NCBI, ExPASy, EBI, Israel, Japan]
Brown D.M., Zeef L.A.H., Ellis J., Goodacre R., Turner S.R.;
"Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics.";
Plant Cell 17:2281-2295(2005).
[4]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
DOI=10.1007/s00425-004-1472-6; PubMed=15940465 [NCBI, ExPASy, EBI, Israel, Japan]
McCaig B.C., Meagher R.B., Dean J.F.D.;
"Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana.";
Planta 221:619-636(2005).
[5]
TISSUE SPECIFICITY.
DOI=10.1093/jxb/erl022; PubMed=16804053 [NCBI, ExPASy, EBI, Israel, Japan]
Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.;
"Mutant identification and characterization of the laccase gene family in Arabidopsis.";
J. Exp. Bot. 57:2563-2569(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC003028; AAC27158.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY052669; AAK96573.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY063730; AAL36080.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY065187; AAL38363.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY114636; AAM47955.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T01240; T01240.
RefSeq NP_565881.1; -.
UniGene At.12454
3D structure databases
HSSP Q9Y780; 1HFU. [HSSP ENTRY / PDB]
ModBase O80434.
Organism-specific databases
TAIR At2g38080; -.
Gene expression databases
ArrayExpress O80434; -.
Ontologies
GO
GO:0009834; Biological process: plant-type secondary cell wall biogenesis (inferred from mutant phenotype from TAIR).
QuickGo view.
Family and domain databases
InterPro IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
IPR017761; Laccase.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.420; Cupredoxin; 3.
Pfam PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
Pfam graphical view of domain structure.
PROSITE PS00079; MULTICOPPER_OXIDASE1; 1.
PS00080; MULTICOPPER_OXIDASE2; 1.
BLOCKS O80434.
Genome annotation databases
GeneID 818386; -.
GenomeReviews CT485783_GR; AT2G38080.
KEGG ath:AT2G38080; -.
NMPDR fig|3702.1.peg.10916; -.
Other
ProtoNet O80434.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Apoplast; Complete proteome; Copper; Glycoprotein; Lignin degradation; Metal-binding; Oxidoreductase; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    24  24     Potential. 
CHAIN   25   558  534     Laccase-4. PRO_0000283632
DOMAIN   32   148  117     Plastocyanin-like 1. 
DOMAIN   158   308  151     Plastocyanin-like 2. 
DOMAIN   408   542  135     Plastocyanin-like 3. 
METAL   82    82        Copper 1; type 2 (By similarity). 
METAL   84    84        Copper 2; type 3 (By similarity). 
METAL   127   127        Copper 2; type 3 (By similarity). 
METAL   129   129        Copper 3; type 3 (By similarity). 
METAL   459   459        Copper 4; type 1 (By similarity). 
METAL   462   462        Copper 1; type 2 (By similarity). 
METAL   464   464        Copper 3; type 3 (By similarity). 
METAL   521   521        Copper 3; type 3 (By similarity). 
METAL   522   522        Copper 4; type 1 (By similarity). 
METAL   523   523        Copper 2; type 3 (By similarity). 
METAL   527   527        Copper 4; type 1 (By similarity). 
CARBOHYD   37    37        N-linked (GlcNAc...) (Potential). 
CARBOHYD   78    78        N-linked (GlcNAc...) (Potential). 
CARBOHYD   114   114        N-linked (GlcNAc...) (Potential). 
CARBOHYD   187   187        N-linked (GlcNAc...) (Potential). 
CARBOHYD   296   296        N-linked (GlcNAc...) (Potential). 
CARBOHYD   323   323        N-linked (GlcNAc...) (Potential). 
CARBOHYD   330   330        N-linked (GlcNAc...) (Potential). 
CARBOHYD   373   373        N-linked (GlcNAc...) (Potential). 
CARBOHYD   383   383        N-linked (GlcNAc...) (Potential). 
CARBOHYD   400   400        N-linked (GlcNAc...) (Potential). 
CARBOHYD   418   418        N-linked (GlcNAc...) (Potential). 
CARBOHYD   441   441        N-linked (GlcNAc...) (Potential). 
CARBOHYD   479   479        N-linked (GlcNAc...) (Potential). 
CARBOHYD   545   545        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 558 AA [This is the length of the unprocessed precursor] Molecular weight: 61527 Da [This is the MW of the unprocessed precursor] CRC64: C3BA6184D88E87DC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGSHMVWFLF LVSFFSVFPA PSESMVRHYK FNVVMKNVTR LCSSKPTVTV NGRYPGPTIY 

        70         80         90        100        110        120 
AREDDTLLIK VVNHVKYNVS IHWHGVRQVR TGWADGPAYI TQCPIQPGQV YTYNYTLTGQ 

       130        140        150        160        170        180 
RGTLWWHAHI LWLRATVYGA LVILPKRGVP YPFPKPDNEK VIVLGEWWKS DTENIINEAL 

       190        200        210        220        230        240 
KSGLAPNVSD SHMINGHPGP VRNCPSQGYK LSVENGKTYL LRLVNAALNE ELFFKVAGHI 

       250        260        270        280        290        300 
FTVVEVDAVY VKPFKTDTVL IAPGQTTNVL LTASKSAGKY LVTASPFMDA PIAVDNVTAT 

       310        320        330        340        350        360 
ATVHYSGTLS SSPTILTLPP PQNATSIANN FTNSLRSLNS KKYPALVPTT IDHHLFFTVG 

       370        380        390        400        410        420 
LGLNACPTCK AGNGSRVVAS INNVTFIMPK TALLPAHYFN TSGVFTTDFP KNPPHVFNYS 

       430        440        450        460        470        480 
GGSVTNMATE TGTRLYKLPY NATVQLVLQD TGVIAPENHP VHLHGFNFFE VGRGLGNFNS 

       490        500        510        520        530        540 
TKDPKNFNLV DPVERNTIGV PSGGWVVIRF RADNPGVWFM HCHLEVHTTW GLKMAFLVEN 

       550 
GKGPNQSILP PPKDLPKC 

O80434 in FASTA format

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