[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Horst H39; Schaap P.J., Mueller Y., Visser J.; "Molecular structure and spatial expression of housekeeping genes in mushrooms."; Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Y17825; CAA76875.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

Q63639; 1BI9. [HSSP ENTRY / PDB]

ModBase

O74187.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 500`	`500`	`Aldehyde dehydrogenase.`	`PRO_0000056435`
`NP_BIND`	`246 251`	`6`	`NAD (By similarity).`
`ACT_SITE`	`269 269`		`Proton acceptor (By similarity).`
`ACT_SITE`	`303 303`		`Nucleophile (By similarity).`
`SITE`	`170 170`	`1`	`Transition state stabilizer (By similarity).`

Sequence information

Length: 500 AA [This is the length of the unprocessed precursor]

Molecular weight: 54395 Da [This is the MW of the unprocessed precursor]

CRC64: C4FCE58B50855925 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPSIFTHQWD TPVYKGSTSI NTGLFINGEF VDGVKNTTID VVNPANGKLI TKISEATEAD 

        70         80         90        100        110        120 
IDIAVEAAHK AFETTWGLNC SGSKRGDMLY KLAQLMEKNI DDLSAIEALD NGKTFLWAKS 

       130        140        150        160        170        180 
VDLSLSISTI KHYAGWADKN FGQVIETDEK KLTYSRHEPI GVVGQIIPWN FPLLMLAWKI 

       190        200        210        220        230        240 
GPALATGNCI VLKPSEFTPL SALRMCALIQ EAGFPPGVVN VVTGYGSTTG QAISSHMKID 

       250        260        270        280        290        300 
KVAFTGSTLV GRKVMEAAAK SNLKNVTLEL GGKSPVVIFD DADLEQSVNW TAHGLFWNHG 

       310        320        330        340        350        360 
QACCAGTRIF VQEGIYDKFL QKFTDKIKEI KLGDPFGLGI DQGPQVSQIQ YDRIMSYIES 

       370        380        390        400        410        420 
GRAEGATVHV GGERHGNEGY FIQPTIFTDT TPDMKIVKEE IFGPVGAVIK FKDGKEVIKQ 

       430        440        450        460        470        480 
ANDSNYGLAA AVFSQDINKA IETAHAFKAG TAWVNCANTI DAGVPFGGYK QSGIGRELGE 

       490        500 
YALHNYTNVK AVHVNLNWKM

O74187 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools