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UniProtKB/Swiss-Prot entry O61309

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NOS_LYMST
Primary accession number O61309
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 67)
Name and origin of the protein
Protein name Nitric oxide synthase
Synonyms EC 1.14.13.39
Neuronal NOS
N-NOS
nNOS
NOS type I
Gene name
Name: NOS
From
Lymnaea stagnalis (Great pond snail) [TaxID: 6523] 
Taxonomy Eukaryota; Metazoa; Mollusca; Gastropoda; Pulmonata; Basommatophora; Lymnaeoidea; Lymnaeidae; Lymnaea.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
TISSUE=CNS;
DOI=10.1002/(SICI)1097-4695(199804)35:1<65::AID-NEU6>3.0.CO;2-9; PubMed=9552167 [NCBI, ExPASy, EBI, Israel, Japan]
Korneev S.A., Piper M.R., Picot J., Phillips R., Korneeva E.I., O'Shea M.;
"Molecular characterization of NOS in a mollusc: expression in a giant modulatory neuron.";
J. Neurobiol. 35:65-76(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF012531; AAC17487.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T31080; T31080.
3D structure databases
HSSP P29477; 1DD7. [HSSP ENTRY / PDB]
ModBase O61309.
Family and domain databases
InterPro IPR003097; FAD-binding_1.
IPR001094; Flavdoxin_like.
IPR008254; Flavodoxin/NO_synth.
IPR001709; FPN_cyt_redctse.
IPR004030; NO_synthase_oxygenase_reg.
IPR012144; NOS.
IPR001433; OxRdtase_FAD/NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.340.10; NO_synthase_oxygenase_reg; 1.
Pfam PF00667; FAD_binding_1; 1.
PF00258; Flavodoxin_1; 1.
PF00175; NAD_binding_1; 2.
PF02898; NO_synthase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000333; NOS; 1.
PRINTS PR00369; FLAVODOXIN.
PR00371; FPNCR.
PROSITE PS51384; FAD_FR; 1.
PS50902; FLAVODOXIN_LIKE; 1.
PS60001; NOS; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O61309.
Other
ProtoNet O61309.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Calmodulin-binding; FAD; FMN; Heme; Iron; Metal-binding; NADP; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1153  1153     Nitric oxide synthase. PRO_0000170949
DOMAIN   427    610  184     Flavodoxin-like. 
DOMAIN   660    903  244     FAD-binding FR-type. 
REPEAT   934    940  7     1. 
REPEAT   941    947  7     2. 
REPEAT   948    954  7     3. 
REPEAT   955    961  7     4. 
REPEAT   962    968  7     5. 
REPEAT   969    975  7     6. 
REPEAT   976    982  7     7. 
REPEAT   983    989  7     8. 
REPEAT   990    996  7     9. 
REPEAT   997   1003  7     10. 
REPEAT   1004   1010  7     11. 
NP_BIND   556    587  32     FMN (By similarity). 
NP_BIND   697    708  12     FAD (By similarity). 
NP_BIND   836    846  11     FAD (By similarity). 
NP_BIND   911    929  19     NADP (By similarity). 
NP_BIND   1089   1104  16     NADP (By similarity). 
REGION   397    417  21     Calmodulin-binding (Potential). 
REGION   934   1010  77     11 X 7 AA tandem repeats of E-[NTR]-[ST]-[IM]-[PLQ]-[SP]-[CW]. 
METAL   82     82        Iron (heme axial ligand) (By similarity). 
VAR_SEQ   276    309        Missing (in isoform Short). VSP_003584
Sequence information
Length: 1153 AA [This is the length of the unprocessed precursor] Molecular weight: 129086 Da [This is the MW of the unprocessed precursor] CRC64: 101B77D02B66B109 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGSLSQQAHG PPDAPRSKEE LLIHAKDFIN QYFTSFQMNK TRAHFHRLGE INDLIEKSGT 

        70         80         90        100        110        120 
YDLTMAELTF GAKHAWRNAP GCIGRSQWSK LQVFDAREIG TPREMFEALC SHIRYATNEG 

       130        140        150        160        170        180 
KIRSTITIFP QRKEGRPDFR VWNTQLISYA GYKLGDGKVI GDPANVEFTE MCVEMGWKPK 

       190        200        210        220        230        240 
HGMFDLLPLV LSAAENSPEY FELPTELVLE VTLKHPEYPW FAEMGLKWYA LPTDSGMLLD 

       250        260        270        280        290        300 
CGGLEFPSCP FNGWFMGTMI GSRNLCDPHR YNMLEPIGLK MGLNTETASS LWKDRVLIEV 

       310        320        330        340        350        360 
NVAVLYSFES ANVTIVNHHD ASTDFISHMD KEIKLRGGCP SDWVRMVPPM SGSTLEVFHQ 

       370        380        390        400        410        420 
EMLLYNLHPA FVRQDVKPWK KHVWKSDQSV PINSCNPKRK LGFKALARAV EFSASLMSKA 

       430        440        450        460        470        480 
LSSRVKCSIF YATETGRSER FARRLSEIFK PVFHSRVVCM DDYAVETLEH ESLVMVITST 

       490        500        510        520        530        540 
FGNGEPPENG KQFAQSLLDM KRKYDCDLGF LESCSSISTC IKSSILTEGP LAADVIGDRQ 

       550        560        570        580        590        600 
SLAMGTGPLC NVRFAVFGLG SKAYPYYAAY GKYIYLMLQE LGAERLVNYC AGDALYGQEQ 

       610        620        630        640        650        660 
SFRAWSEEVF KASCEAFCLD NRNDAPGPQT KGDCSKVRIV PVENCQEPDL CQVLRNIHGK 

       670        680        690        700        710        720 
EVMPLILAER IQLQAKDSDQ QTILIKLDAH NATDLKYAPG DHVAIFPANS PEIVDAILVR 

       730        740        750        760        770        780 
LDTSKGPSPD QVVKTEISTQ LGTNDTWRSH LPICTSRTAF SFLLDVTTPP SQEILQVLAT 

       790        800        810        820        830        840 
QASSDMDKHK LEQLASNSEA YEKWRLDLSP NILEILDEFP SLKIPPSLLL TQLPLLQPRY 

       850        860        870        880        890        900 
YSISSSQQKN PNEVHATIAV VRFKTQDGDG PVHEGVCSSW LNRSPIGTVV PCFLRSAPHF 

       910        920        930        940        950        960 
HLPEDPSLPI IMIGPGSGIA PFRSFWQQRL GEIENTMPSC ENTMLSCETT IPSCENSMPS 

       970        980        990       1000       1010       1020 
CENTMPSCEN TMPSCENTIP SCENTIPSCE NTMPSCENTI PSWERTMQPC QIILPSQTKK 

      1030       1040       1050       1060       1070       1080 
HFGEMVLYTG CRTAKHMIYA AELEEMKRLG VLSNYHVALS REAALPKMYV QDIIIKNAAA 

      1090       1100       1110       1120       1130       1140 
VYEIVMKKGG HFYVSGDVSM AHDVTRALEL VLCQQGGREA SQQVMSLRDE NLFHEDIFGS 

      1150 
FVRKAGGQRS EDE
O61309 in FASTA format

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