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UniProtKB/Swiss-Prot entry O61199

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ODO1_CAEEL
Primary accession number O61199
Secondary accession numbers None
Integrated into Swiss-Prot on May 2, 2006
Sequence was last modified on October 1, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 51)
Name and origin of the protein
Protein name 2-oxoglutarate dehydrogenase E1 component, mitochondrial [Precursor]
Synonyms EC 1.2.4.2
Alpha-ketoglutarate dehydrogenase
Gene name
ORFNames: T22B11.5
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
[2]
 PROTEIN SEQUENCE OF 126-146; 297-317; 320-328; 372-391; 504-514; 548-565; 622-633; 673-680; 910-918; 975-984 AND 992-1002, AND MASS SPECTROMETRY.
Bienvenut W.V.;
Submitted (MAR-2006) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF039040; AAB94185.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T15098; T15098.
RefSeq NP_500617.1; -.
UniGene Cel.17820
3D structure databases
ModBase O61199.
Organism-specific databases
WormBase WBGene00020679; T22B11.5.
WormPep T22B11.5; CE28486. [WormPep / WorfDB]
Gene expression databases
ArrayExpress O61199; -.
Ontologies
GO
GO:0031966; Cellular component: mitochondrial membrane (inferred from sequence or structural similarity from UniProtKB).
GO:0004591; Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0009792; Biological process: embryonic development ending in birth or egg hatching (inferred from mutant phenotype from WormBase).
GO:0006091; Biological process: generation of precursor metabolites and energy (inferred from sequence or structural similarity from UniProtKB).
GO:0002119; Biological process: nematode larval development (inferred from mutant phenotype from WormBase).
GO:0040010; Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
QuickGo view.
Family and domain databases
InterPro IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.
PANTHER PTHR23152; 2oxoglutarate_DH_E1; 1.
Pfam PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000157; Oxoglu_dh_E1; 1.
TIGRFAMs TIGR00239; 2oxo_dh_E1; 1.
BLOCKS O61199.
Genome annotation databases
Ensembl T22B11.5; Caenorhabditis elegans. [Contig view]
GeneID 177235; -.
KEGG cel:T22B11.5; -.
NMPDR fig|6239.3.peg.13185; -.
Other
ProtoNet O61199.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; Glycolysis; Mitochondrion; Oxidoreductase; Thiamine pyrophosphate; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
TRANSIT   1      ?        Mitochondrion. 
CHAIN   ?   1029        2-oxoglutarate dehydrogenase E1 component, mitochondrial. PRO_0000234100
Sequence information
Length: 1029 AA [This is the length of the unprocessed precursor] Molecular weight: 115661 Da [This is the MW of the unprocessed precursor] CRC64: 71ECB0F4236135F4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MHRASLICRL ASPSRINAIR NASSGKSHIS ASTLVQHRNQ SVAAAVKHEP FLNGSSSIYI 

        70         80         90        100        110        120 
EQMYEAWLQD PSSVHTSWDA YFRNVEAGAG PGQAFQAPPA TAYAGALGVS PAAAQVTTSS 

       130        140        150        160        170        180 
APATRLDTNA SVQSISDHLK IQLLIRSYQT RGHNIADLDP LGINSADLDD TIPPELELSF 

       190        200        210        220        230        240 
YGLGERDLDR EFLLPPTTFI SEKKSLTLRE ILQRLKDIYC TSTGVEYMHL NNLEQQDWIR 

       250        260        270        280        290        300 
RRFEAPRVTE LSHDQKKVLF KRLIRSTKFE EFLAKKWPSE KRFGLEGCEV LIPAMKQVID 

       310        320        330        340        350        360 
SSSTLGVDSF VIGMPHRGRL NVLANVCRQP LATILSQFST LEPADEGSGD VKYHLGVCIE 

       370        380        390        400        410        420 
RLNRQSQKNV KIAVVANPSH LEAVDPVVMG KVRAEAFYAG DEKCDRTMAI LLHGDAAFAG 

       430        440        450        460        470        480 
QGVVLETFNL DDLPSYTTHG AIHIVVNNQI GFTTDPRSSR SSPYCTDVGR VVGCPIFHVN 

       490        500        510        520        530        540 
VDDPEAVMHV CNVAADWRKT FKKDVIVDLV CYRRHGHNEL DEPMFTQPLM YQRIKQTKTA 

       550        560        570        580        590        600 
LEKYQEKILN EGVANEQYVK EELTKYGSIL EDAYENAQKV TYVRNRDWLD SPWDDFFKKR 

       610        620        630        640        650        660 
DPLKLPSTGI EQENIEQIIG KFSQYPEGFN LHRGLERTLK GRQQMLKDNS LDWACGEALA 

       670        680        690        700        710        720 
FGSLLKEGIH VRLSGQDVQR GTFSHRHHVL HDQKVDQKIY NPLNDLSEGQ GEYTVCNSSL 

       730        740        750        760        770        780 
SEYAVLGFEL GYSMVDPNSL VIWEAQFGDF SNTAQCIIDQ FISSGQSKWI RQSGLVMLLP 

       790        800        810        820        830        840 
HGYEGMGPEH SSARPERFLQ MCNEDDEIDL EKIAFEGTFE AQQLHDTNWI VANCTTPANI 

       850        860        870        880        890        900 
YHLLRRQVTM PFRKPAVVFS PKSLLRHPMA RSPVEDFQSG SNFQRVIPET GAPSQNPPDV 

       910        920        930        940        950        960 
KRVVFCTGKV YYDMVAARKH VGKENDVALV RVEQLSPFPY DLVQQECRKY QGAEILWAQE 

       970        980        990       1000       1010       1020 
EHKNMGAWSF VQPRINSLLS IDGRATKYAG RLPSSSPATG NKFTHMQEQK EMMSKVFGVP 


KSKLEGFKA
O61199 in FASTA format

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