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UniProtKB/Swiss-Prot entry O60078


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TYR1_SCHPO
Primary accession number O60078
Secondary accession number P78863
Integrated into Swiss-Prot on May 23, 2003
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 48)
Name and origin of the protein
Protein name Probable prephenate dehydrogenase [NADP+]
Synonyms PRDH
EC 1.3.1.13
Gene name
ORFNames: SPCC1494.04c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-431.
STRAIN=PR745;
DOI=10.1093/dnares/4.6.363; PubMed=9501991 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
"Identification of open reading frames in Schizosaccharomyces pombe cDNAs.";
DNA Res. 4:363-369(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329672; CAA19302.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D89213; BAA13874.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T41005; T41005.
T43017; T43017.
RefSeq NP_588529.1; -.
3D structure databases
ModBase O60078.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-000428-MON; -.
Organism-specific databases
GeneDB_Spombe SPCC1494.04c; -.
Gene expression databases
ArrayExpress O60078; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0004665; Molecular function: prephenate dehydrogenase (NADP+) activity (inferred from mutant phenotype from GeneDB_SPombe).
GO:0006571; Biological process: tyrosine biosynthetic process (inferred from mutant phenotype from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR003099; Prephen_DHase.
IPR012385; Prephenate_DHase_fun.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02153; PDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036510; PDH_fung; 1.
PROSITE PS51176; PDH_ADH; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O60078.
Genome annotation databases
GeneID 2539274; -.
KEGG spo:SPCC1494.04c; -.
NMPDR fig|4896.1.peg.867; -.
Other
ProtoNet O60078.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase; Tyrosine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   431  431     Probable prephenate dehydrogenase [NADP+]. PRO_0000119207
DOMAIN   5   285  281     Prephenate/arogenate dehydrogenase. 
NP_BIND   5    34  30     NADP (Potential). 
CONFLICT   429   431        QKM -> KKCDFLIAAFCVYNS (in Ref. 2; BAA13874). 
Sequence information
Length: 431 AA [This is the length of the unprocessed precursor] Molecular weight: 48906 Da [This is the MW of the unprocessed precursor] CRC64: C598458426E620D7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKETFQVGII GFGDMGRLYA EYISKAGWRV NVCDRPENYE SIQATYGNGG YTVLKDGFQV 

        70         80         90        100        110        120 
SRTSDYILYS VEAEHIDKVV ALYGPATKVG AIVGGQTSCK APEMNAFEKY LPEDVDIISC 

       130        140        150        160        170        180 
HSMHGPKVNP KSQPLVIIRH RASDEHFEIV NEILSCFKSS VVYLSAKEHD RITADTQAVT 

       190        200        210        220        230        240 
HAAFLTMGLA WHANNQYPWE INRWCGGIEN IKMNLSMRIY SSKWHVYAGL AILNPEAQRQ 

       250        260        270        280        290        300 
IQQYASSVTE LFKLAISGKA KEYEDRIRNA GKFVFGENMD RNSSGLLLSD ELLDQYSISN 

       310        320        330        340        350        360 
IPKDESKRNS HLSILAIVDS WSKLGIHPQN HMICSTPLFR LWVGVSEYVF RHPGLLDSCI 

       370        380        390        400        410        420 
YTATKHNDFS PDDLEFVVAV RSWSECVAAK DFTTYKKRFL ETQEYFRPRF EEATRVGNAM 

       430 
ISKLLENLQK M 

O60078 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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