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UniProtKB/Swiss-Prot entry O59812


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD2_SCHPO
Primary accession number O59812
Secondary accession numbers None
Integrated into Swiss-Prot on May 20, 2008
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name Probable glucose-6-phosphate 1-dehydrogenase C794.01c
Synonyms G6PD
EC 1.1.1.49
Gene name
ORFNames: SPCC794.01c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nbt1222; PubMed=16823372 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329672; CAA19129.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T41610; T41610.
RefSeq NP_587749.1; -.
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase O59812.
Organism-specific databases
GeneDB_Spombe SPCC794.01c; -.
Gene expression databases
ArrayExpress O59812; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0006010; Biological process: glucose 6-phosphate utilization (inferred by curator from GeneDB_SPombe).
GO:0009051; Biological process: pentose-phosphate shunt, oxidative branch (inferred by curator from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
BLOCKS O59812.
Genome annotation databases
GeneID 2539576; -.
KEGG spo:SPCC794.01c; -.
NMPDR fig|4896.1.peg.87; -.
Other
ProtoNet O59812.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Cytoplasm; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   475  475     Probable glucose-6-phosphate 1-dehydrogenase C794.01c. PRO_0000337687
ACT_SITE   238   238        Proton acceptor (By similarity). 
BINDING   10    10        NADP (By similarity). 
BINDING   42    42        NADP (By similarity). 
BINDING   176   176        Substrate (By similarity). 
Sequence information
Length: 475 AA [This is the length of the unprocessed precursor] Molecular weight: 53510 Da [This is the MW of the unprocessed precursor] CRC64: C2CBB43BD6E70C45 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLSIIVFGAS GDLATKMTFP ALFALYVRKI IPEDFQIIGY ARSKLSQEAA NKIVTAHIPI 

        70         80         90        100        110        120 
DDTVGASQKA LNTFVEHYKY VPGTYDKPES FEMLNSIIAE KETAPASECT RIFYLVLPPH 

       130        140        150        160        170        180 
LFAPVSELIK SKAHPNGMVT RLIVEKPIGF DYKSADAILS DLSKHWSAKD TFKVDHFLGE 

       190        200        210        220        230        240 
DMIDGFTAIR FANSMFEPIW NREHIESVRV DFREDFGCEG RGGYFEGAGI LRDVVQNHLL 

       250        260        270        280        290        300 
QLLTLLCIEE PKSQDAEDII KCKVDFLKSL HPVSKEDIVY GQYTKSANGK VPGYRELDGV 

       310        320        330        340        350        360 
ADDSEVSTFC ALQLRSEAPR WKGIPIIISA GKGLDRDYFE ARITFKRREG GMFPTVDSSN 

       370        380        390        400        410        420 
VLVLRVYPKE FIALKGHIKQ PGFSRQIVPV TLDVKYPEAF PDTWIHKAYE VVIADAINGK 

       430        440        450        460        470 
HTHFISDDEV RTSWKIFDDV LDTTGDLSPL PYAFGSHHGP DATLEFFKKR NLEWD 

O59812 in FASTA format

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