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UniProtKB/Swiss-Prot entry O59650

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHE3_PYRKO
Primary accession number O59650
Secondary accession number Q5JDK3
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on January 23, 2007 (Sequence version 4)
Annotations were last modified on    July 22, 2008 (Entry version 52)
Name and origin of the protein
Protein name Glutamate dehydrogenase
Synonyms GDH
EC 1.4.1.3
Gene name
Name: gdhA
OrderedLocusNames: TK1431
From
Pyrococcus kodakaraensis (Thermococcus kodakaraensis) [TaxID: 69014] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-11.
STRAIN=KOD1;
DOI=10.1007/s004380050655; PubMed=9520268 [NCBI, ExPASy, EBI, Israel, Japan]
Rahman R.N.Z.A., Fujiwara S., Takagi M., Imanaka T.;
"Sequence analysis of glutamate dehydrogenase (GDH) from the hyperthermophilic archaeon Pyrococcus sp. KOD1 and comparison of the enzymatic characteristics of native and recombinant GDHs.";
Mol. Gen. Genet. 257:338-347(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=KOD1;
DOI=10.1101/gr.3003105; PubMed=15710748 [NCBI, ExPASy, EBI, Israel, Japan]
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
Genome Res. 15:352-363(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D89911; BAA25261.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP006878; BAD85620.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T44789; T44789.
RefSeq YP_183844.1; -.
3D structure databases
HSSP O74024; 1EUZ. [HSSP ENTRY / PDB]
SMR O59650; 5-420.
ModBase O59650.
Enzyme and pathway databases
BioCyc TKOD69014:TK1431-MON; -.
Ontologies
GO
GO:0004353; Molecular function: glutamate dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11606:SF2; GLFV_DH; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000185; Glu_DH; 1.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
BLOCKS O59650.
Genome annotation databases
GeneID 3234478; -.
GenomeReviews AP006878_GR; TK1431.
KEGG tko:TK1431; -.
NMPDR fig|69014.3.peg.1302; -.
Phylogenomic databases
HOGENOM O59650; -.
Genome annotation databases
CMR O59650; TK1431.
Other
ProtoNet O59650.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Direct protein sequencing; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   421  420     Glutamate dehydrogenase. PRO_0000182759
NP_BIND   220   226  7     NAD (Potential). 
ACT_SITE   105   105        By similarity. 
CONFLICT   138   138        W -> C (in Ref. 1; BAA25261). 
CONFLICT   347   347        A -> T (in Ref. 1; BAA25261). 
Sequence information
Length: 421 AA [This is the length of the unprocessed precursor] Molecular weight: 47056 Da [This is the MW of the unprocessed precursor] CRC64: 13EF3F1DD1602E51 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVEIDPFEMA VQQLERAAQF MDISEEALEW LKRPMRIVEV SVPVEMDDGS VKVFTGFRVQ 

        70         80         90        100        110        120 
HNWARGPTKG GIRWHPAETL STVKALATWM TWKVAVVDLP YGGGKGGIIV DPKKLSEREQ 

       130        140        150        160        170        180 
ERLARSYIRA VYDVIGPWTD IPAPDVYTNP KIMAWMMDEY ETIMRRKGPA FGVITGKPPG 

       190        200        210        220        230        240 
VGGIVARMDA TARGAAFTIR EAAKALGWDD LKGKTIAIQG YGNAGYYLHK IMSEEFGMKV 

       250        260        270        280        290        300 
VAVSDSKGGI YNPDGLPPAD EVLKWKKEHG SVKDMPGTQN ITNEELLELE VDILAPSAIE 

       310        320        330        340        350        360 
GVITKENADN VKAKIVAEVA NGPVTPEADE ILHEKGILQI PDFLCNAGGV TVSYFEWVQN 

       370        380        390        400        410        420 
INGFYWTVEE TRKRLDDKMT KAFWDVFNTH KEKNIHMRDA AYVVAVSRVY EAMKHRGWVK 


K
O59650 in FASTA format

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