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UniProtKB/Swiss-Prot entry O54705

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NOS2_CAVPO
Primary accession number O54705
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on June 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 71)
Name and origin of the protein
Protein name Nitric oxide synthase, inducible
Synonyms EC 1.14.13.39
Inducible NO synthase
Inducible NOS
iNOS
NOS type II
Gene name
Name: NOS2
Synonyms: NOS
From
Cavia porcellus (Guinea pig) [TaxID: 10141] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricognathi; Caviidae; Cavia.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Hartley;
TISSUE=Lung;
PubMed=9677342 [NCBI, ExPASy, EBI, Israel, Japan]
Shirato M., Sakamoto T., Uchida Y., Nomura A., Ishii Y., Iijima H., Goto Y., Hasegawa S.;
"Molecular cloning and characterization of Ca2+-dependent inducible nitric oxide synthase from guinea-pig lung.";
Biochem. J. 333:795-799(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF027180; AAC33177.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P29477; 1DD7. [HSSP ENTRY / PDB]
SMR O54705; 82-501.
ModBase O54705.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from sequence or structural similarity from UniProtKB).
GO:0042742; Biological process: defense response to bacterium (inferred from sequence or structural similarity from UniProtKB).
GO:0006801; Biological process: superoxide metabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR003097; FAD-binding_1.
IPR001094; Flavdoxin_like.
IPR008254; Flavodoxin/NO_synth.
IPR001709; FPN_cyt_redctse.
IPR004030; NO_synthase_oxygenase_reg.
IPR012144; NOS.
IPR001433; OxRdtase_FAD/NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.340.10; NO_synthase_oxygenase_reg; 1.
Pfam PF00667; FAD_binding_1; 1.
PF00258; Flavodoxin_1; 1.
PF00175; NAD_binding_1; 1.
PF02898; NO_synthase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000333; NOS; 1.
PRINTS PR00369; FLAVODOXIN.
PR00371; FPNCR.
PROSITE PS51384; FAD_FR; 1.
PS50902; FLAVODOXIN_LIKE; 1.
PS60001; NOS; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O54705.
Phylogenomic databases
HOVERGEN O54705; -.
Other
ProtoNet O54705.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Calmodulin-binding; FAD; FMN; Heme; Iron; Metal-binding; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1149  1149     Nitric oxide synthase, inducible. PRO_0000170929
DOMAIN   538    676  139     Flavodoxin-like. 
DOMAIN   729    969  241     FAD-binding FR-type. 
NP_BIND   622    653  32     FMN (By similarity). 
NP_BIND   766    777  12     FAD (By similarity). 
NP_BIND   902    912  11     FAD (By similarity). 
NP_BIND   977    995  19     NADP (By similarity). 
NP_BIND   1075   1090  16     NADP (By similarity). 
REGION   508    528  21     Calmodulin-binding (Potential). 
METAL   199    199        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 1149 AA [This is the length of the unprocessed precursor] Molecular weight: 130632 Da [This is the MW of the unprocessed precursor] CRC64: 66D595A2486DB50E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MACPWNFLWK LKSSRYDLTE EKDINNNVGK ASHLYSPEIQ DDPKYCSPGK HQNGSSQSLT 

        70         80         90        100        110        120 
GTAKKVPESQ SKPHKPSPTC SQHMKIKNWG NGMILQDTLH TKAKTNFTCK PKSCLGSVMN 

       130        140        150        160        170        180 
PRSMTRGPRD TPIPPDELLP QAIEFVNQYY DSFKEAKIEE YLARVETVTK EIETTGTYQL 

       190        200        210        220        230        240 
TGDELIFATK LAWRNAPRCI GRIQWSNLQV FDARSCHTAQ EMFEHICRHV RYSTNNGNIR 

       250        260        270        280        290        300 
SAITVFPQRT DGKHDFRVWN AQLIRYAGYQ MPDGTIQGDP ANLEFTQLCI DLGWKPRYGR 

       310        320        330        340        350        360 
FDVLPLILQA DGRDPELFEI PPDLVLEVPM EHPKYEWFQD LGLKWYALPA VANMLLEVGG 

       370        380        390        400        410        420 
LEFPACPFNG WYMGTEIGVR DFCDAQRYNI LEEVGRRMGL ETHTLASLWK DRAVTEINVA 

       430        440        450        460        470        480 
VLHSFQKQNV TIMDHHSAAE SFMKHMQNEY RARGGCPADW IWLVPPISGS ITPVFHQEML 

       490        500        510        520        530        540 
NYILSPFYYY QVEAWKTHVW QDETRRPKRR EIPFRVLAKA TLFASLLMRK MMASRVRATI 

       550        560        570        580        590        600 
LFATETGKSE ALAQDLGALF SCAFNPKVLC MDQYQLSSLE EEKLLLVVTS TFGNGDCPGN 

       610        620        630        640        650        660 
GETLKKSLFV LKKLTNTFRY AVFGLGSSMY PRFCAFAHDI DIKLSQLGAS QLTPVGEGDE 

       670        680        690        700        710        720 
LSGQEDAFCT WAVQTFQAAC AAFDVRGRHH ITIPKRYTSS VTWEPYHYRL VQDSQPLDLN 

       730        740        750        760        770        780 
KALSRMHATD VFTMRLKSQK NLQSPKSSRT TLLMELSCDD SRSLAYLPGE HLGVFPCNQP 

       790        800        810        820        830        840 
ALVQGILECV VDNPGPHHTV CLEVLDDSGS YWAKDKRLPP CSLSQALTYF LDITTPPTQL 

       850        860        870        880        890        900 
QLQKLARLAT EQAERLRLES LSQPSEYNKW KFTNSPTFLE VLEEFPSLRV PAAFLLSQLP 

       910        920        930        940        950        960 
ILKPRYYSIS SSLDHTPAEV HLTVAVVTYR TRDGRGPLHH GVCSTWFSGL KPQDPVPCLV 

       970        980        990       1000       1010       1020 
RSVNSFQLPK DPSQPCILIG PGTGIAPFRS FWQQRLHNLK HTGLQGGRMT LLFGCRHPEE 

      1030       1040       1050       1060       1070       1080 
DHIYKEEMQE MVQKGVLHEV HTAYSRLPGK PKAYVQDILR QQLAREVLRV LHEEPGHLYV 

      1090       1100       1110       1120       1130       1140 
CGNVLMAQDV ACTLKQLLAA KLNLNEEQVE DYFFQLKSQK RYHEDIFGAV FPHGVKKDRA 


ERPPGDDKL
O54705 in FASTA format

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