NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Carina;
TISSUE=Meristem;
Krupinska K., Falk J.;
"cDNA sequence encoding a barley 4-hydroxyphenylpyruvate dioxygenase with enhanced expression in meristematic leaf tissue and during leaf senescence.";
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O₂ = homogentisate + CO₂.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6 .
PATHWAY: Context: Prenylquinones biosynthesis .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the 4HPPD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ000693; CAA04245.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T04471; T04471.

3D structure databases

SMR

O48604; 28-424.

ModBase

O48604.

Organism-specific databases

Gramene

O48604; -.

Family and domain databases

InterPro

IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.

PANTHER

PTHR11959; HPP_dOase; 1.

Pfam

PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF009283; HPP_dOase; 1.

TIGR01263; 4HPPD; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 434`	`434`	`4-hydroxyphenylpyruvate dioxygenase.`	`PRO_0000088399`
`METAL`	`211 211`		`Iron (By similarity).`
`METAL`	`293 293`		`Iron (By similarity).`
`METAL`	`379 379`		`Iron (By similarity).`

Sequence information

Length: 434 AA [This is the length of the unprocessed precursor]

Molecular weight: 46550 Da [This is the MW of the unprocessed precursor]

CRC64: 42DE721182654A4C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPPTPTTPAA TGAAAAVTPE HARPHRMVRF NPRSDRFHTL SFHHVEFWCA DAASAAGRFA 

        70         80         90        100        110        120 
FALGAPLAAR SDLSTGNSAH ASQLLRSGSL AFLFTAPYAN GCDAATASLP SFSADAARRF 

       130        140        150        160        170        180 
SADHGIAVRS VALRVADAAE AFRASRRRGA RPAFAPVDLG RGFAFAEVEL YGDVVLRFVS 

       190        200        210        220        230        240 
HPDGTDVPFL PGFEGVTNPD AVDYGLTRFD HVVGNVPELA PAAAYIAGFT GFHEFAEFTA 

       250        260        270        280        290        300 
EDVGTTESGL NSVVLANNSE GVLLPLNEPV HGTKRRSQIQ TFLEHHGGPG VQHIAVASSD 

       310        320        330        340        350        360 
VLRTLRKMRA RSAMGGFDFL PPPLPKYYEG VRRLAGDVLS EAQIKECQEL GVLVDRDDQG 

       370        380        390        400        410        420 
VLLQIFTKPV GDRPTLFLEM IQRIGCMEKD ERGEEYQKGG CGGFGKGNFS ELFKSIEDYE 

       430 
KSLEAKQSAA VQGS

O48604 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools